ABSTRACT
A para-articular osteochondroma is a rare osteocartilaginous tumour that arises in the soft tissue adjacent to a joint but with no attachment to the bone. To our knowledge, this is the first case of one reported in the region of the temporomandibular joint (TMJ). The patient presented with severe preauricular pain caused by a para-auricular osteochondroma, which arose in the preauricular region just external to the TMJ.
Subject(s)
Osteochondroma/diagnosis , Soft Tissue Neoplasms/diagnosis , Temporomandibular Joint/pathology , Female , Humans , Magnetic Resonance Imaging , Mandibular Condyle/pathology , Middle Aged , Radiography, Panoramic , Tomography, X-Ray ComputedABSTRACT
A 73-year-old man presented with a painful swelling of the left temporomandibular joint with no other symptoms. Panoramic radiography showed an osteolytic lesion in the left mandibular body, while magnetic resonance imaging provided the most accurate view of an osteolytic lesion in the left condyle. Skeletal scintigraphy showed increased uptake in the mandibular anatomical area. A diagnosis of metastatic breast adenocarcinoma was made from mandibular biopsies which proved to be ductal carcinoma, with no evidence of any other metastases. Clinicopathologic features of this case are reviewed.
Subject(s)
Breast Neoplasms, Male/pathology , Carcinoma, Ductal, Breast/secondary , Mandibular Neoplasms/secondary , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms, Male/diagnostic imaging , Breast Neoplasms, Male/drug therapy , Carcinoma, Ductal, Breast/diagnostic imaging , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast/pathology , Cyclophosphamide/therapeutic use , Epirubicin/therapeutic use , Fluorouracil/therapeutic use , Humans , Magnetic Resonance Imaging , Male , Mandibular Condyle/pathology , Mandibular Neoplasms/diagnostic imaging , Mandibular Neoplasms/drug therapy , RadiographyABSTRACT
Giant cell angiofibroma was first described as a distinctive orbital soft-tissue tumour in male adults; it is now recognized that this mesenchymal tumour can present in other anatomical regions. In this article, a case of giant cell angiofibroma of parapharyngeal space in a 25-year-old woman is described. Clinicopathologic features of this tumour are reviewed. To the authors' knowledge, this is the first reported case of giant cell angiofibroma arising in the parapharyngeal space.
Subject(s)
Angiofibroma/diagnosis , Parotid Neoplasms/diagnosis , Pharyngeal Neoplasms/diagnosis , 12E7 Antigen , Adult , Antigens, CD/analysis , Antigens, CD34/analysis , Biopsy, Fine-Needle , Capillaries/pathology , Cell Adhesion Molecules/analysis , Cell Nucleus/ultrastructure , Diagnosis, Differential , Female , Follow-Up Studies , Giant Cells/pathology , Humans , Intranuclear Inclusion Bodies/ultrastructure , Proto-Oncogene Proteins c-bcl-2/analysis , Tomography, X-Ray Computed , Vimentin/analysisABSTRACT
Wilms' tumour (WT) is the most common solid tumour of childhood. The molecular signalling pathways determining the origin and behaviour of WT are very complex and several genes in several loci may participate. This review tries to briefly compile recent works on the histology and on the molecular alterations that promote the genesis, development and behaviour of WT. Some molecular alterations seem to be associated with specific histological types and particular clinical outcomes, suggesting that they might be utilised to determine the prognosis and to identify poor prognostic subgroups that can be targeted for more individualised treatments (AU)
No disponible
Subject(s)
Humans , Male , Female , Abnormalities, Multiple/genetics , Chromosome Aberrations , Genes, Wilms Tumor , Kidney Neoplasms/genetics , Wilms Tumor/diagnosis , Wilms Tumor/genetics , Kidney Neoplasms/pathology , Wilms Tumor/pathologySubject(s)
Breast Diseases , Adolescent , Breast Diseases/diagnosis , Child , Child, Preschool , Female , Humans , Infant , MaleABSTRACT
No disponible
Subject(s)
Male , Female , Child , Adolescent , Humans , Breast Diseases/diagnosis , Biopsy, Fine-NeedleABSTRACT
We reviewed 98 cases of fine needle aspiration of soft tissue tumors with histologic confirmation performed during an eight-year period and propose a working morphologic classification based on the most prominent cytologic features. Six main tumor groups are recognized: myxoid, round cells, spindle cells, pleomorphic cells, polygonal cells and well differentiated. We believe that this classification allows recognition of the most common soft tissue tumors while helping with the differential diagnosis of other neoplasia, primary or secondary, with similar morphology and a similar presentation.
Subject(s)
Soft Tissue Neoplasms/pathology , Adolescent , Adult , Aged , Biopsy, Needle , Child , Humans , Middle Aged , Soft Tissue Neoplasms/classificationABSTRACT
Fibromatosis is the proliferation of connective tissue with local infiltrative growth and a tendency to relapse in contrast with fibrosarcoma which never produces metastases. Two patients, a mother and son diagnosed with fibromatosis of initial cervical location in whom surgical extirpation and complementary radiotherapy were performed. The mother underwent polychemotherapy (adriamicine plus dacarbazine) because of extensive relapse. Definitive resolution was achieved in both cases.
Subject(s)
Fibroma/genetics , Head and Neck Neoplasms/genetics , Muscular Diseases/genetics , Soft Tissue Neoplasms/genetics , Thoracic Neoplasms , Thoracic Neoplasms/genetics , Adolescent , Adult , Combined Modality Therapy , Female , Fibroma/therapy , Head and Neck Neoplasms/therapy , Humans , Male , Muscular Diseases/therapy , Remission Induction , Soft Tissue Neoplasms/therapy , Thoracic Neoplasms/therapyABSTRACT
The authors carried out a histochemical study with lectins (Ulex europaeus agglutinin-I [UEA-I], Triticum vulgaris [WGA], Glycine max [SBA], Dolichos biflorus [DBA], and Arachis hypogaea [PNA]) in different thyroid gland conditions (17 benign nodular goiters, three diffuse hyperplasias, five Hashimoto's thyroiditis, 20 follicular adenomas, 14 well-differentiated papillary carcinomas, five well-differentiated follicular carcinomas, and 30 normal thyroids) in order to determine if specific lectin patterns are developed during neoplastic transformation. The results showed that (1) in normal thyroid glands, the lectin, UEA-I, is able to discriminate between follicular cells and C-cells; (2) pathologic follicular epithelium had an increased expression of UEA-I, SBA, and WGA receptors; (3) no lectin or group of lectins allow a distinction between follicular carcinoma and papillary carcinoma; (4) when benign and malignant tumors are compared for UEA-I affinity there is a significantly greater frequency of malignant tumour with UEA-I receptor; and (5) although all investigated lectins have shown receptors in endothelial cells at least in one case, the most constant findings have been obtained with UEA-I and WGA. These findings suggest that lectins are not useful in routine diagnostic pathologic examination; however, in particular cases of follicular carcinoma, UEA-I may be a useful tool for the recognition of small vessels invaded by tumoral cells and the demonstration of fucose residues in malignant tumor cells.
