ABSTRACT
The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to be particularly vulnerable to SARS-CoV-2 infection. Here we have obtained a comprehensive picture of the impact of COVID-19 in MM patients on a local and a global scale using a federated data research network (TriNetX) that provided access to Electronic Medical Records (EMR) from Health Care Organizations (HCO) all over the world. Through propensity score matched analyses we found that the number of new diagnoses of MM was reduced in 2020 compared to 2019 (RR 0.86, 95%CI 0.76-0.96) and the survival of newly diagnosed MM cases decreased similarly (HR 0.61, 0.38-0.81). MM patients showed higher risk of SARS-CoV-2 infection (RR 2.09, 1.58-2.76) and a higher excess mortality in 2020 (difference in excess mortality 9%, 4.4-13.2) than non-MM patients. By interrogating large EMR datasets from HCO in Europe and globally, we confirmed that MM patients have been more severely impacted by COVID-19 pandemic than non-MM patients. This study highlights the necessity of extending preventive measures worlwide to protect vulnerable patients from SARS-CoV-2 infection by promoting social distancing and an intensive vaccination strategies.
Subject(s)
COVID-19/epidemiology , Multiple Myeloma/epidemiology , Adult , Female , Global Health/statistics & numerical data , Humans , Male , Middle Aged , SARS-CoV-2ABSTRACT
En los ámbitos administrativos y clínicos, el funcionamiento de un Hospital sin papel, exige previamente un esfuerzo estratégico de definición importante, donde tiene un peso considerable la integración de toda la información. Esto no evita la aparición, durante su utilización, de problemas de usabilidad, de seguridad e incluso de integridad de la información. La solución de estos problemas, dentro del propio hospital y cuando se pretende que la información esté disponible extramuros, es garantizar la interoperabilidad semántica para lo cual hay que recurrir a la utilización de estándares del modelo de referencia y de vocabularios controlados, preferiblemente dentro de una ontología (AU)
The operation of a Hospital completely without papers, in the administrative and clinical areas, requires carrying out a task of definition in order to ensure inter-operability through controlled standards of reference and vocabulary models, preferably within an established ontology capable of preventing any problems of usability and exchange of knowledge. This article explains the optimum process for introducing and using the Electronic Medical Record based on these precepts (AU)
