Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension.

BACKGROUND: Physical exercise is a well-established strategy to control blood pressure. Nonetheless, its effects on protein homeostasis in individuals with hypertension are not clearly defined. AIMS: Evaluate proteostasis, quality of life, and inflammation, oxidative stress, and vasoactive biomarkers in adults with hypertension regarding reported exercise habits. METHODS: Twenty individuals were recruited in a health-care centre, 10 regular exercisers (age: 68.3 ± 4.2 years) and 10 age-matched individuals without regular exercise participation (age: 67.7 ± 5.1 years). Proteostasis and the levels of ubiquitin, heat shock protein 70 (Hsp70), endothelial nitric oxide synthase (eNOS), matrix metalloproteinases 2 (MMP-2), tissue inhibitor of MMP-2 (TIMP-2), connexin 43 (Cx43) and extracellular superoxide dismutase-3 (SOD-3) were assessed in plasma using immunoblotting techniques (western blot or slot blot) and Fourier-transform infrared spectroscopy (FTIR). Quality of life was assessed using the Short Form 36 (SF-36) version 2.0 questionnaire. RESULTS: Significant higher levels of interleukin (IL)-6 (P = 0.014), eNOS (P = 0.011), Cx43 (P = 0.020), TIMP-2 (P = 0.038), and SOD-3 (P = 0.001), with a fold increase of 1.5, 1.2, 2.1, 1.3, and 1.2, respectively, were found in the exercise group. The overall quality of life (60.1 ± 4.3 vs. 53.2 ± 5.9, P = 0.009), as well as mental health domain (59.4 ± 7.9 vs. 50.7 ± 7.2, P = 0.024) were significantly higher in the exercise group. Multivariate analysis by FTIR showed that the age-matched group is characterized by peaks related with antiparallel ß-sheet, whereas exercise group is characterized by peaks related to random coils, ß-sheet, and α-helix. CONCLUSIONS: Individuals with regular exercise participation showed better proteostasis, quality of life, inflammatory profile, antioxidant defenses, and eNOS levels.

Suppressing Li Metal Dendrites Through a Solid Li-Ion Backup Layer.

The growing demand for sustainable and off-grid energy storage is reviving the attempts to use Li metal as the anode in the next generation of batteries. However, the use of Li anodes is hampered due to the growth of Li dendrites upon charging and discharging, which compromises the life and safety of the battery. Here, it is shown that lithiated multiwall carbon nanotubes (Li-MWCNTs) act as a controlled Li diffusion interface that suppresses the growth of Li dendrites by regulating the Li+ ion flux during charge/discharge cycling at current densities between 2 and 4 mA cm-2 . A full Li-S cell is fabricated to showcase the versatility of the protected Li anode with the Li-MWCNT interface, where the full cells could support pulse discharges at high currents and over 450 cycles at different rates with coulombic efficiencies close to 99.9%. This work indicates that carbon materials in lithiated forms can be an effective and simple approach to the stabilization of Li metal anodes.

Laminated Object Manufacturing of 3D-Printed Laser-Induced Graphene Foams.

Laser-induced graphene (LIG), a graphene structure synthesized by a one-step process through laser treatment of commercial polyimide (PI) film in an ambient atmosphere, has been shown to be a versatile material in applications ranging from energy storage to water treatment. However, the process as developed produces only a 2D product on the PI substrate. Here, a 3D LIG foam printing process is developed on the basis of laminated object manufacturing, a widely used additive-manufacturing technique. A subtractive laser-milling process to yield further refinements to the 3D structures is also developed and shown here. By combining both techniques, various 3D graphene objects are printed. The LIG foams show good electrical conductivity and mechanical strength, as well as viability in various energy storage and flexible electronic sensor applications.

Lithium Batteries with Nearly Maximum Metal Storage.

The drive for significant advancement in battery capacity and energy density inspired a revisit to the use of Li metal anodes. We report the use of a seamless graphene-carbon nanotube (GCNT) electrode to reversibly store Li metal with complete dendrite formation suppression. The GCNT-Li capacity of 3351 mAh g-1GCNT-Li approaches that of bare Li metal (3861 mAh g-1Li), indicating the low contributing mass of GCNT, while yielding a practical areal capacity up to 4 mAh cm-2 and cycle stability. A full battery based on GCNT-Li/sulfurized carbon (SC) is demonstrated with high energy density (752 Wh kg-1 total electrodes, where total electrodes = GCNT-Li + SC + binder), high areal capacity (2 mAh cm-2), and cyclability (80% retention at >500 cycles) and is free of Li polysulfides and dendrites that would cause severe capacity fade.

[Seroconversion in response to a reinforced primary hepatitis B vaccination in children with cancer]. / Seroconversión frente a primovacunación reforzada contra hepatitis B en niños con cáncer.

INTRODUCTION: Immune response against vaccine antigens may be impaired in children with cancer. The aim of this study was to evaluate the seroconversion response against hepatitis B vaccination (HBV) at the time of chemotherapy onset and/or remission in children with cancer. PATIENTS AND METHOD: Prospective, two-centre, controlled, non-randomised study conducted on children recently diagnosed with cancer, paired with healthy subjects. Cases received HBV at time 0, 1 and 6 months with DNA recombinant HBV at a dose of 20 and 40 µg if < or > than 10 years of age, respectively, at the time of diagnosis for solids tumours and after the remission in case of haematological tumours. Controls received the same schedule, but at of 10 and 20 µg doses, respectively. HBs antibodies were measured in serum samples obtained at 2, 8 and 12 months post-vaccination. Protective titres were defined as > 10 mIU/ml at 8th month of follow up. RESULTS: A total of 78 children with cancer and 25 healthy controls were analysed at month 8th of follow up. Seroconversion rates in the cancer group reached 26.9%, with no differences by age, gender or type of tumour (P = .13, .29, and .44, respectively). Control group seroconversion was 100% at the 8th month, with P < .0001 compared with the cancer group. At month 12 of follow up, just 31.9% of children with cancer achieved anti-HBs antibodies > 10 mIU/ml. CONCLUSIONS: Vaccination against hepatitis B with three doses of DNA recombinant vaccine at an increased concentration, administrated at the time of onset of chemotherapy and/or remission provided an insufficient immune response in a majority of children with cancer. More immunogenic vaccines should be evaluated in this special population, such as a third generation, with more immunogenic adjuvants, enhanced schedules at 0, 1, 2, 6 month, evaluation of antibody titres at month 8 and 12h to evaluate the need for further booster doses.

Seroconversión frente a primovacunación reforzada contra hepatitis B en niños con cáncer / Seroconversion in response to a reinforced primary hepatitis B vaccination in children with cancer

Introducción: La respuesta inmune a los antígenos de las vacunas está disminuida en los niños con cáncer. El objetivo de este estudio fue evaluar la seroconversión frente a vacuna ADN recombinante contra hepatitis B al momento del inicio de la quimioterapia y/o remisión en niños con cáncer. Pacientes y método: Estudio prospectivo, bicéntrico, controlado, no aleatorizado de niños con diagnóstico reciente de cáncer pareados con niños sanos. Los casos fueron vacunados a tiempo 0, 1 y 6 meses, a dosis de 20 y 40 μg si eran < ó > 10 años, respectivamente, con vacuna ADN recombinante contra hepatitis B, en el momento del diagnóstico en el caso de los tumores sólidos y luego de la remisión en el caso de los tumores hematológicos. El grupo control recibió el mismo esquema, con dosis de 10 o 20 μg respectivamente. Se midieron anticuerpos séricos anti-HBs a los 2, 8 y 12 meses posvacunación. Seroconversión se definió como títulos anti-HBs > 10 mUI/ml al octavo mes. Resultados: Un total de 78 niños con cáncer y 25 controles fueron evaluados con títulos anti-HBs al octavo mes. La tasa de seroconversión fue de 26,9%, en niños con cáncer, sin diferencia por edad, género ni tipo de tumor (p = 0,13; 0,29; y 0,44, respectivamente), y de 100% en el grupo control (p < 0,0001, comparado con los niños con cáncer). En el seguimiento a los 12 meses solo el 31,9% de los niños con cáncer presentaba títulos anti-HBs > 10 mUI/ml. Conclusiones: La vacunación contra hepatitis B con vacuna ADN recombinante, con esquema reforzado de 3 dosis, en el momento del inicio de la quimioterapia y/o remisión provee una respuesta inmune insuficiente en la mayoría de los niños con cáncer. En esta población debieran evaluarse vacunas de tercera generación, con adyuvantes más inmunogénicos, esquemas reforzados a los 0, 1, 2 y 6 meses, medición de títulos de anticuerpos al octavo y duodécimo mes, eventual uso de refuerzos y reevaluación de inmunogenicidad si correspondiese.

Introduction: Immune response against vaccine antigens may be impaired in children with cancer. The aim of this study was to evaluate the seroconversion response against hepatitis B vaccination (HBV) at the time of chemotherapy onset and/or remission in children with cancer. Patients and method: Prospective, two-centre, controlled, non-randomised study conducted on children recently diagnosed with cancer, paired with healthy subjects. Cases received HBV at time 0, 1 and 6 months with DNA recombinant HBV at a dose of 20 and 40 μg if < or > than 10 years of age, respectively, at the time of diagnosis for solids tumours and after the remission in case of haematological tumours. Controls received the same schedule, but at of 10 and 20 μg doses, respectively. HBs antibodies were measured in serum samples obtained at 2, 8 and 12 months post-vaccination. Protective titres were defined as > 10 mIU/ml at 8th month of follow up. Results: A total of 78 children with cancer and 25 healthy controls were analysed at month 8th of follow up. Seroconversion rates in the cancer group reached 26.9%, with no differences by age, gender or type of tumour (P = .13, .29, and .44, respectively). Control group seroconversion was 100% at the 8th month, with P < .0001 compared with the cancer group. At month 12 of follow up, just 31.9% of children with cancer achieved anti-HBs antibodies > 10 mIU/ml. Conclusions: Vaccination against hepatitis B with three doses of DNA recombinant vaccine at an increased concentration, administrated at the time of onset of chemotherapy and/or remission provided an insufficient immune response in a majority of children with cancer. More immunogenic vaccines should be evaluated in this special population, such as a third generation, with more immunogenic adjuvants, enhanced schedules at 0, 1, 2, 6 month, evaluation of antibody titres at month 8 and 12 h to evaluate the need for further booster doses.

Stabilization of amorphous paracetamol based systems using traditional and novel strategies.

There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely known for its instability when prepared in the amorphous state. In the present work thermally stable amorphous binary paracetamol based systems were obtained showing stability on a wide range of temperatures: below its glass transition temperature (Tg) as amorphous solids in the glassy state and above their glass transition temperature, where these materials exist as stable supercooled liquids. To achieve stabilization of the binary paracetamol based system several strategies were applied and optimized, being the selection of the container material a key and novel approach to control the mechanical stress during cooling, eliminating cracks which act as nucleation centers leading to crystallization.

Projeto para Qualificação dos Profissionais da Atenção Básica no Atendimento a Vítimas de Acidentes de Trânsito no Município de Igarassu – PE / Design for the Professional Qualification in Primary Care for Victims of Traffic Accidents in the City of Igarassu – PE

Este projeto teve como objetivo qualificar os profissionais da Atenção Básica do Município de Igarassu no atendimento as vítimas de Acidentes de Trânsito, devido a esse agravo à saúde ocupar posições alarmantes no que se refere ao número de vítimas e ocorrência de lesões graves e traumas, implicando altos custos diretos ou indiretos a saúde pública e sociedade. Como meta o projeto busca realizar cursos, divididos em vinte e cinco turmas (25 equipes) com oito horas cada; qualificar 82 (oitenta e dois) profissionais, sendo 25 médicos, 26 enfermeiras, 31 técnicas de enfermagem da Atenção Básica; desse modo, definir estratégias para executar as ações construídas nos cursos de capacitação para o atendimento as vítimas de acidentes de trânsito junto aos órgãos envolvidos SAMU, DENATRAN e NUPS...

Má oclusão Classe III de Angle tratada com extrações de dentes permanentes: relato de caso / Angle Class III malocclusion treated with extraction of permanent teeth: case report

Este artigo teve como objetivo relatar o retratamento ortdôntico de uma paciente do gênero feminino, adulta, que apresentava uma má oclusão Classe III de Angle, com ausência do dente 34 e sintomatologia dolorosa da ATM. Este caso foi apresentado à diretoria do Board Brasileiro de Ortodontia e Ortopedia Facial (BBO), como parte dos requisitos para obtenção do título de Diplomado pelo BBO.

This article aimed at describing the orthodontic retreatment of an adult female patient presenting Angle Class III malocclusion with absence of tooth 34 and painful symptoms of TMJ. This case was previously presented to the Directores of the Brazilian Board of Orthodontics and Facial Orthopedics (BBO) as part of the requirements to become a BBO Diplomate.

Impacto psicosocial y calidad de vida en sobreviviente de cáncer infantil / Psychosocial impact and quality of life in childhood cancer survivors

El avance en las terapias oncológicas trae consigo un aumento progresivo en la sobrevida de los niños con cáncer, lo que implica la necesidad de un abordaje integral en el cuidado de estos pacientes. En Chile no existen reportes formales sobre los efectos psicosociales en sobrevivientes de cáncer infantil. Con el fin de identificar el impacto psicosocial y calidad de vida, se realiza una revisión de literatura utilizando las bases de datos PubMed, Proquest Nursing Journals, EBM Reviews, Scielo y CINHAL. La búsqueda comprende textos completos de los últimos cinco años, en inglés y español. Se encuentran 91 artículos y se seleccionan 22 investigaciones cuantitativas y cualitativas. Los resultados muestran que el impacto psicosocial se manifiesta principalmente por baja autoestima e incertidumbre hacia el futuro, así como problemas de relaciones sociales en las áreas de empleo e independencia financiera, rendimiento académico y relaciones de pares y matrimonio las que se encuentran relacionadas con baja percepción en la calidad de vida. Por otra parte se observa mejor aceptación de sus limitaciones, adaptabilidad a las situaciones negativas y madurez psicológica. La experiencia de vivir con cáncer genera múltiples efectos en la vida de los niños sobrevivientes a nivel psicosocial. En Chile es fundamental que la enfermera, profesional encargada de la gestión del cuidado, realice seguimiento integral a los pacientes pediátricos desde el diagnóstico, promoviendo el autocuidado para mejorar su calidad de vida.

The advances in cancer therapies bring a progressive increase in survival of cancer among children, which implies the need for a more holistic approach of care for these patients. In Chile there are no formal reports about the psychosocial effects of childhood cancer survivors. To identify the psychosocial impact and quality of life, a literature review was done using databases: PubMed, Proquest Nursing Journals, EBM Reviews, Scielo and CINAHL. The search limits included: full texts of the last five years in English and Spanish. Ninety-one articles were found and 22 of them were selected using the criteria of having a quantitative or qualitative design. The results demostrate that the psychosocial impact is manifested mainly by low self-esteem and uncertainty toward the future, and problems of social relationships in areas such as employment, financial independence, academic performance and marriage, and relating to peers, which were related to low perceived quality of life. Also, greater acceptance of limitations, adaptability to negative situations and psychological maturity were identified. The experience of living with cancer produces multiple psychological effects in the lives of surviving children. In Chile, it is essential that the nurses in charge of child oncology care, management make a follow up of pediatric patients, beginning from the time of diagnosis, promoting self-care, and thereby improving quality of life.

Estudio del síndrome posflebítico en 30 pacientes quemados / A study postphlebitic syndrome in 30 burnt patients

Se estudiaron 30 casos, que sufrieron quemaduras en miembros inferiores, independientemente de la causa, y que presentaron edema en el miembro afectado, dolor y úlcera(s) (síndrome posflebítico). Se comprobó la presencia de este síndrome mediante estudio imagenológico (flebografía anterógrada), lo cual permite plantear que el síndrome posflebítico es una complicación inmediata de las quemaduras secundario a trombosis venosa que se presenta con mucha mayor frecuencia de lo que se piensa y que debe ser detectada a tiempo, pues una vez producida, ésta es irreversible. Se sugieren medidas encaminadas a evitar este síndrome en pacientes con quemaduras

Estudio del síndrome posflebótico en 30 pacientes quemados / Study of the syndrome postphlebotic óptic in 30 patient burns

Se estudiaron 30 casos, que sufrieron quemaduras en miembros inferiores, independientemente de la causa, y que presentaron edema en el miembro afectado, dolor y úlcera(s) (síndrome posflebítico). Se comprobó la presencia de este síndrome mediante estudio imagenológico (flebografía anterógrada), lo cual permite plantear que el síndrome posflebítico es una complicación inmediata de las quemaduras secundario a trombosis venosa que se presenta con mucha mayor frecuencia de lo que se piensa y que debe ser detectada a tiempo, pues una vez producida, ésta es irreversible. Se sugieren medidas encaminadas a evitar este síndrome en pacientes con quemaduras (AU)

Reconstrucción mamaria posmastectomíacon implante de silicona: a propósito de 12 casos (resultados preliminares) / Breast reconstruction with silicone-gel implants after mastectomy: an example of 12 cases (preliminary results)

La reconstrucción mamaria posmastectomía se considera actualmente parte integral del tratamiento multidisciplinario del carcinoma de la mama. La colocación de implantes de silicona es una de las modalidades de ésta. Su utilización ha sido recientemente objeto de revisión, dada la existencia de temores con relación al surgimiento de trastornos autoinmunes a causa de su empleo sistemático. En este trabajo se hace una revisión actualizada del tema y se muestran los resultados preliminares de una serie de 12 pacientes mastectomizadas por cáncer de mama, que fueron sometidas a este proceder en el Instituto Nacional de Oncología y Radiobiología, entre 1992 y 1998 (primer trimestre). Se describen los procederes quirúrgicos y se muestran las principales complicaciones que tuvieron lugar. Se consideran alentadores los resultados obtenidos, aunque los aspectos cosméticos deben ser protocolizados adecuadamente en un futuro próximo. Se informa sobre las perspectivas de la reconstrucción mamaria en el INOR, en dependencia de lo reportado por los principales autores a nivel internacional(AU)