Synthesis of disordered mesoporous silica loaded with ultrasmall-sized CuO nanoparticles based on an alkali-free strategy and its excellent catalytic performance in the reduction of organic dye.

In this paper, disordered mesoporous silica loaded with ultrasmall-sized and highly dispersed CuO nanoparticles was obtained by an alkali-free strategy. Pre-prepared copper bromoacetate (CuBA) and (3-aminopropyl)triethoxysilane (APTES) were selected as reactants, which can be covalently connected with each other for the formation of functional hybrid precursors. Simultaneously, the protonated amino group with the ability to promote the hydrolysis of silane was generated, avoiding any additional catalyst. The covalent introduction of copper salt by chemical bonding promised the molecular-level dispersion of copper ions, favouring the in situ generation of ultrasmall-sized and highly dispersed CuO nanoparticles in the silica matrix. The average diameter of this obtained composited silica material is around 700 nm, and CuO nanoparticles with an average diameter of ∼3 nm were uniformly dispersed in the silica matrix. Typically, disordered mesopores were obtained under the thermolysis of organic chains in the hybrid silica matrix; the BET surface area is 77 m2 g-1 and the pore diameter is about 2.5 nm. The catalytic property was investigated and the results show that this obtained CuO@mSiO2 material has good catalytic performance in the reduction of organic dye with NaBH4 as the reducing agent.

Correlation between white matter hyperintensities and the outcomes after reperfusion therapy in patients with acute ischemic stroke / 国际脑血管病杂志

Objective:To investigate the correlation between white matter hyperintensities (WMHs) and the outcomes after reperfusion therapy in patients with acute ischemic stroke (AIS).Methods:Patients with AIS treated with reperfusion therapy (intravenous thrombolysis, endovascular mechanical thrombectomy or bridging therapy) in the Stroke Center of Zhongshan Hospital of traditional Chinese Medicine from January 2014 to December 2019 were retrospectively enrolled. The clinical baseline data of the patients were collected. The Fazekas scale was used to evaluate the severity of WMHs according to the MRI images. At 90 d after discharge, the modified Rankin Scale was used to evaluate the outcomes. A score of ≤ 2 was defined as good outcome, and a score of >2 was defined as poor outcome. Binary multivariate logistic regression analysis was used to determine the independent risk factors for hemorrhagic transformation (HT), symptomatic intracranial hemorrhage (sICH), and poor outcomes. Results:A total of 676 patients with AIS treated with reperfusion therapy were enrolled. Among them, 506 patients (74.9%) were complicated with WMHs, and 80 (11.8%) had severe WMHs. One hundred and thirty-two patients (19.5%) had HT, 34 (5.0%) had sICH, and 306 (45.3%) had a poor outcome. Multivariate logistic regression analysis showed that severe WMHs was an independent risk factor for the occurrence of HT (odds ratio [ OR] 1.890, 95% confidence interval [ CI] 1.047-3.413; P=0.035) and poor outcomes ( OR 3.366, 95% CI 1.567-7.232; P=0.002) after reperfusion treatment in patients with AIS, but there was no independent correlation with sICH ( OR 8.403, 95% CI 0.891-79.294; P=0.063). Conclusion:Severe WMHs is an independent risk factor for the occurrence of HT and poor outcomes in patients with AIS after reperfusion treatment, but it has no independent correlation with sICH.

Reperfusion therapy and post-stroke seizures and post-stroke epilepsy / 国际脑血管病杂志

Reperfusion therapy has become a standard treatment for acute ischemic stroke, which can effectively improve the outcomes of patients and reduce the mortality. Some studies have found that reperfusion therapy may increase the incidence of post-stroke seizures and post-stroke epilepsy, but this view is still controversial. This article reviews the recent studies on reperfusion therapy and post-stroke seizures and post-stroke epilepsy.

Mitochondrial DNA mutations and aminoglycoside antibiotics and hearing loss / 临床耳鼻咽喉头颈外科杂志

Mitochondrial DNA mutations are one of the most important causes of sensorineural hearing loss. A1555G and C1494T mutations of mitochondrial 12S rRNA gene are the molecular basis for aminoglycoside hyper- sensitivity and can lead to aminoglycoside-induced hearing loss. Primary mutations in tRNA such as tRNA(Ser(UCN))7472insC are associated with syndromic hearing loss. While other mutations such as tRNA"(Se(UCN) )G7444A were considered synergy with the primary RNA mutations, modulating the phenotypic manifestation. This review de- scribes a detailed summary of hearing loss associated with mtDNA mutations and/or aminoglycoside antibiotics, and provides the possible molecular mechanisms in deafness expression.