ABSTRACT
PURPOSE: To evaluate visual acuity and morphologic changes after photobiomodulation (PBM) for patients affected with large soft drusen and/or drusenoid pigment epithelial detachment associated with dry age-related macular degeneration. METHOD: Twenty eyes with large soft drusen and/or drusenoid pigment epithelial detachment age-related macular degeneration were included and treated using the LumiThera Valeda Light Delivery System. All patients underwent two treatments per week for 5 weeks. Outcome measures included best-corrected visual acuity, microperimetry-scotopic testing, drusen volume, central drusen thickness, and quality of life score at baseline and month 6 (M6) follow-up. Data of best-corrected visual acuity, drusen volume, and central drusen thickness were also recorded at week 5 (W5). RESULTS: Best-corrected visual acuity significantly improved at M6 with a mean score gain of 5.5 letters ( P = 0.007). Retinal sensitivity decreased by 0.1 dB ( P = 0.17). The mean fixation stability increased by 0.45% ( P = 0.72). Drusen volume decreased by 0.11 mm 3 ( P = 0.03). Central drusen thickness was reduced by a mean of 17.05 µ m ( P = 0.01). Geographic atrophy area increased by 0.06 mm 2 ( P = 0.01) over a 6-month follow-up, and quality of life score increased by 3,07 points on average ( P = 0.05). One patient presented a drusenoid pigment epithelial detachment rupture at M6 after PBM treatment. CONCLUSION: The visual and anatomical improvements in our patients support previous reports on PBM. PBM may provide a valid therapeutic option for large soft drusen and drusenoid pigment epithelial detachment age-related macular degeneration and may potentially slow the natural course of the disease.
Subject(s)
Geographic Atrophy , Low-Level Light Therapy , Macular Degeneration , Retinal Detachment , Retinal Drusen , Humans , Pilot Projects , Prospective Studies , Quality of Life , Macular Degeneration/complications , Retinal Drusen/complications , Retinal Detachment/complications , Geographic Atrophy/complications , Tomography, Optical Coherence , Follow-Up StudiesABSTRACT
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms, known as DRESS syndrome, is a rare drug induced hypersensitivity reaction syndrome. METHODS: case resport. RESULTS: We describe a patient who presented with acute erythematous rash on her face, fever>38ºC, lymphadenopathy, blood abnormalities, and reaction suspected to be amoxicillin clavulanate-related. The patient also had an associated bilateral redness of the conjunctiva, peripheral corneal infiltrates, and anterior chamber with 3+ cells. CONCLUSION: We describe the first occurrence of bilateral marginal corneal infiltrates and acute anterior uveitis associated with amoxicillin clavulanate-induced DRESS syndrome and discuss its pathogenesis.
Subject(s)
Corneal Diseases , Drug Hypersensitivity Syndrome , Eosinophilia , Uveitis, Anterior , Corneal Diseases/chemically induced , Corneal Diseases/diagnosis , Drug Hypersensitivity Syndrome/diagnosis , Drug Hypersensitivity Syndrome/etiology , Eosinophilia/chemically induced , Eosinophilia/diagnosis , Eosinophilia/drug therapy , Female , Fever/chemically induced , Fever/complications , Humans , Uveitis, Anterior/complicationsABSTRACT
Objetivos: evaluar el rendimiento incremental del análisis de microarrays genómicos sobre cariotipado convencional en nuestra serie de microarrays prenatales. Métodos: 393 mujeres embarazadas sometidas a un diagnóstico prenatal invasivo debido a malformaciones fetales, aumento de la translucencia nucal o restricción del crecimiento fetal de inicio temprano entre febrero de 2012 y agosto de 2015, a quienes se les ofreció realizar un análisis de microarrays genómicos y aceptaron. Resultados: el rendimiento de diagnóstico incremental sobre cariotipado convencional fue del 3,6% (IC del 95%: 1,7-5,5). Esta tasa aumentó a 4,7% (95% IC 1,7-7,7) en anomalías estructurales aisladas. Conclusiones: el microarray genómico proporciona un rendimiento incremental del 3,6% sobre el cariotipado convencional en fetos con anomalías de ultrasonido y otras indicaciones específicas (AU)
Objectives: To assess the incremental yield of genomic microarray analysis over conventional karyotyping in our series of prenatal microarrays. Methods: 393 pregnant women undergoing an invasive prenatal diagnosis due to fetal malformations, increased nuchal translucency or early onset fetal growth restriction between February 2012 and August 2015, were offered and accepted to perform a genomic microarray analysis. Results: The incremental diagnostic yield over conventional karyotyping was 3.6% (95% CI 1.7-5.5). This rate increased to 4.7% (95% CI 1.7-7.7) in isolated structural anomalies. Conclusions: Genomic microarray provides a 3.6% incremental yield over conventional karyotyping in fetuses with ultrasound anomalies and other specific indications (AU)
