ABSTRACT
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Subject(s)
Humans , Female , Middle Aged , Histiocytoma, Benign Fibrous/pathology , Vascular Neoplasms/pathology , Erythema/diagnosis , Skin Diseases, Papulosquamous/diagnosis , Diagnosis, DifferentialSubject(s)
Carcinoma, Verrucous/diagnosis , Facial Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Aged , Biopsy , Carcinoma, Verrucous/etiology , Carcinoma, Verrucous/pathology , Carcinoma, Verrucous/surgery , DNA Probes, HPV , Diagnosis, Differential , Facial Neoplasms/etiology , Facial Neoplasms/pathology , Facial Neoplasms/surgery , Humans , Male , Middle Aged , Neoplasms, Radiation-Induced/diagnosis , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/surgery , Skin Neoplasms/etiology , Skin Neoplasms/pathology , Skin Neoplasms/surgeryABSTRACT
No disponible
No disponible
Subject(s)
Humans , Male , Middle Aged , Aged , Carcinoma, Verrucous/diagnosis , Facial Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Neoplasms, Radiation-Induced/diagnosis , Diagnosis, Differential , DNA Probes, HPV , Biopsy , Carcinoma, Verrucous/etiology , Carcinoma, Verrucous/pathology , Carcinoma, Verrucous/surgery , Facial Neoplasms/etiology , Facial Neoplasms/pathology , Facial Neoplasms/surgery , Skin Neoplasms/etiology , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Neoplasms, Radiation-Induced/pathology , Neoplasms, Radiation-Induced/surgeryABSTRACT
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Subject(s)
Male , Adult , Humans , Dermis/cytology , Dermis/injuries , Dermis/pathology , Immunohistochemistry/methods , Basal Cell Nevus Syndrome/diagnosis , Basal Cell Nevus Syndrome/therapy , Nevus, Pigmented/complications , Nevus, Pigmented/diagnosis , Nevus, Epithelioid and Spindle Cell/complications , Nevus, Epithelioid and Spindle Cell/etiology , Dermis/microbiology , Dermis/surgery , Epithelioid Cells/immunology , Epithelioid Cells/pathology , Diagnosis, DifferentialABSTRACT
No disponible
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Subject(s)
Male , Middle Aged , Humans , Biopsy/methods , Leprosy, Lepromatous/complications , Leprosy, Lepromatous/diagnosis , Leprosy, Lepromatous/therapy , Lepromin , Polymerase Chain Reaction/methods , Rifampin/therapeutic use , Dapsone/therapeutic use , Clofazimine/therapeutic use , Sensitivity and Specificity , Biopsy , Immunity, Cellular , Immunity, Cellular/physiology , Mycobacterium leprae/isolation & purification , Mycobacterium leprae/pathogenicityABSTRACT
Bullous pemphigoid is an autoimmune disease that generally affects elderly people and is characterised by the development of subepidermal blistering. Although bullous pemphigoid is potentially photosensitive, its occurrence during the treatment course with PUVA, especially in patients with psoriasis, has exceptionally been described. The association of bullous pemphigoid and psoriasis gives rise to difficulties when initiating treatment and we consider that the use of methotrexate, with or without associated corticoids, is a good alternative in the management of such patients. We report two further cases of bullous pemphigoid related to PUVA therapy in patients with psoriasis.
Subject(s)
PUVA Therapy/adverse effects , Pemphigoid, Bullous/etiology , Aged , Female , Humans , MaleABSTRACT
Dexketoprofen is the active isomer of ketoprofen and likewise belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) derived from propionic acid. We have recently studied, using patch and photopatch tests, two women with a characteristic clinical picture of contact photodermatitis who had used topical dexketoprofen (Enangel) in the days before onset of the rash. In both cases we used the standard series of GEIDC, a series for NSAIDs, the product itself (Enalgel) and its excipients. On examination of the photopatches of both patients at 96 hours we found positive reactions to dexketoprofen and Enalgel. Furthermore, in one of the women we observed simultaneous photosensitivity to other NSAIDs and to several excipients of Enangel. Reviewing the literature we have found only three references on contact photodermatitis due to dexketoprofen. We describe two new cases, with multiple photosensitivities in one of them. We consider that such patients should be patch tested with dexketoprofen at 0.1-1 % petrolatum, concentrations that are notably inferior to those used in previous publications.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Dermatitis, Phototoxic/etiology , Ketoprofen/analogs & derivatives , Tromethamine/analogs & derivatives , Adult , Female , Humans , Ketoprofen/adverse effects , Middle Aged , Tromethamine/adverse effectsABSTRACT
El penfigoide ampolloso es una enfermedad de etiología autoinmune caracterizada por el desarrollo de ampollas subepidérmicas, que afecta generalmente a personas de edad avanzada. A pesar de que el penfigoide ampolloso tiene un potencial carácter fotosensible, se ha descrito de forma excepcional el desarrollo de dicho proceso en el curso de tratamiento con PUVA, sobre todo en pacientes con psoriasis. La asociación de penfigoide ampolloso y psoriasis plantea dificultad a la hora de instaurar un tratamiento y consideramos una buena alternativa la utilización de metotrexate, con o sin corticoides asociados, en el manejo de dichos pacientes. Aportamos dos nuevos casos de penfigoide ampolloso relacionado con tratamiento con PUVA en pacientes con psoriasis
Bullous pemphigoid is an autoimmune disease that generally affects elderly people and is characterised by the development of subepidermal blistering. Although bullous pemphigoid is potentially photosensitive, its occurrence during the treatment course with PUVA, especially in patients with psoriasis, has exceptionally been described. The association of bullous pemphigoid and psoriasis gives rise to difficulties when initiating treatment and we consider that the use of methotrexate, with or without associated corticoids, is a good alternative in the management of such patients. We report two further cases of bullous pemphigoid related to PUVA therapy in patients with psoriasis
Subject(s)
Male , Female , Middle Aged , Humans , Pemphigoid, Bullous/diagnosis , Pemphigoid, Bullous/therapy , PUVA Therapy/methods , Psoriasis/complications , Psoriasis/therapy , Fluorescent Antibody Technique, Direct/methods , Adrenal Cortex Hormones/therapeutic use , Phototherapy/methods , Photochemotherapy/methods , PUVA Therapy/trends , PUVA Therapy , Photochemotherapy/trends , PhotochemotherapyABSTRACT
El dexketoprofeno es el isómero activo del ketoprofeno y como aquél pertenece al grupo de antiinflamatorios no esteroideos (AINE) derivados del ácido propiónico. Recientemente hemos estudiado con parches y fotoparches a dos mujeres con una clínica característica de fotodermatitis de contacto que habían usado los días previos dexketoprofeno tópico (Enangel®). En ambos casos se empleó la batería estándar del GEIDC, una batería de AINE, el producto propio (Enangel®) y sus excipientes. En las dos pacientes se observaron a las 96 horas fotoparches positivos frente a dexketoprofeno y Enangel®. Además, en una de ellas se evidenciaron fotosensibilizaciones simultáneas a otros AINE y a varios excipientes del Enangel®. Revisando la bibliografía, sólo hemos encontrado tres referencias sobre fotodermatitis de contacto por dexketoprofeno. Aportamos dos nuevos casos, en uno de los cuales se asociaron múltiples fotosensibilidades. Consideramos que estos pacientes deben parchearse con dexketoprofeno al 0,1-1 % vaselina, concentraciones sensiblemente inferiores a las usadas en publicaciones previas
Dexketoprofen is the active isomer of ketoprofen and likewise belongs to the group of non-steoidal anti-inflammatory drugs (NSAIDs) derived from propionic acid. We have recently studied, using patch and photopatch tests, two women with a characteristic clinical picture of contact photodermatitis who had used topical dexketoprofen (Enangel®) in the days before onset of the rash. In both cases we used the standard series of GEIDC, a series for NSAIDs, the product itself (Enangel®) and its excipients. On examination of the photopatches of both patients at 96 hours we found positive reactions to dexketoprofen and Enangel®. Furthermore, in one of the women we observed simultaneous photosensitivity to other NSAIDs and to several excipients of Enangel®. Reviewing the literature we have found only three references on contact photodermatitis due to dexketoprofen. We describe two new cases, with multiple photosensitivities in one of them. We consider that such patients should be patch tested with dexketoprofen at 0.1-1 % petrolatum, concentrations that are notably inferior to those used in previous publications
