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1.
Actas urol. esp ; 40(10): 635-639, dic. 2016.
Article in Spanish | IBECS | ID: ibc-158324

ABSTRACT

Introducción: La mayoría de las guías recomiendan realizar una cistografía miccional (CUMS) temprana tras el tratamiento endoscópico del reflujo vesicoureteral (RVU), pero no hay consenso sobre cómo hacer el seguimiento a largo plazo en este grupo de pacientes. El objetivo de este estudio es analizar si es necesaria la realización de una CUMS tardía en aquellos pacientes tratados con éxito. Material y método: Hemos revisado las historias clínicas de aquellos pacientes tratados de RVU con el copolímero de dextranómero/ácido hialurónico (Dx/AH) desde 2006 a 2010. Se han seleccionado aquellos pacientes que estaban curados tras el tratamiento con más de 3 años de seguimiento y control cistográfico tardío. Hemos analizado los hallazgos clínicos y radiológicos a largo plazo. Resultados: Ciento sesenta niños con 228 uréteres refluyentes recibieron tratamiento con Dx/AH con un seguimiento medio de 52,13 meses. A 215 se les realizó CUMS de forma temprana, siendo la tasa de éxito del 84,1%. El grupo de estudio fueron 94/215 uréteres refluyentes que tuvieron un seguimiento clínico y cistográfico tardío mayor de 3 años. En el 79,8% la CUMS mostró ausencia de RVU, siendo la tasa de éxito tardío clínico del 91,7%. La incidencia de infección del tracto urinario febril entre aquellos que estaban curados desde el punto de vista radiológico frente a aquellos en los que recidivó el RVU fue del 8 y 15%, respectivamente. Solo existieron diferencias significativas en la recidiva del RVU entre aquellos uréteres que se habían tratado de forma inicial con una punción o con 2 punciones de Dx/AH. Conclusión: Si el objetivo del tratamiento del RVU es disminuir las infecciones del tracto urinario febril, no es necesario realizar una CUMS tardía tras un tratamiento exitoso inicial con Dx/AH, a pesar de que la tasa de éxito radiológico es menor que la del clínico


Introduction: Some guidelines recommend an early voiding cystourethrography (VCUG) after endoscopic treatment of vesicoureteral reflux (VUR), but there's no consensus if it's necessary a long-term follow-up in these patients. The aim of our study is analyze if it's necessary a delayed VCUG after initial successful treatment with Dx/HA. Material and method: We have reviewed all medical charts of patients that underwent Dx/HA treatment from 2006 to 2010. We have selected patients with initial successful treatment and more than 3 years of radiological and clinical follow-up. We have analyzed late clinical and radiological outcomes. Results: One hundred and sixty children with 228 refluxing ureters underwent Dx/HA endoscopic treatment with a mean follow-up of 52.13 months. Early VCUG was performed in 215 ureters with an initial successful rate of 84.1%. The group of study was 94/215 ureters with more than 3 years of follow-up with a delayed VCUG. VUR was still resolved in 79,8% of the ureters. Clinical success rate was 91.7%. The incidence of febrile urinary tract infection in those patients with cured VUR and those with a relapsed VUR was 8 and 15%, respectively; but there were no significant differences. We have not found any variable related with relapsed VUR except those ureters that initially received 2 injections (P < .05). Conclusion: If our objective in the treatment of VUR is to reduce the incidence of febrile urinary tract infection it is not necessary to perform a delayed VCUG even though the long-term radiological outcomes is worse than clinical outcome


Subject(s)
Humans , Male , Female , Child , Vesico-Ureteral Reflux/diagnostic imaging , Vesico-Ureteral Reflux/therapy , Hyaluronic Acid/therapeutic use , Cystography , Cystoscopy , Dextrans/therapeutic use , Ureteroscopy , Follow-Up Studies , Remission Induction , Retrospective Studies , Time Factors
2.
Actas Urol Esp ; 40(10): 635-639, 2016 Dec.
Article in English, Spanish | MEDLINE | ID: mdl-27161091

ABSTRACT

INTRODUCTION: Some guidelines recommend an early voiding cystourethrography (VCUG) after endoscopic treatment of vesicoureteral reflux (VUR), but there's no consensus if it's necessary a long-term follow-up in these patients. The aim of our study is analyze if it's necessary a delayed VCUG after initial successful treatment with Dx/HA. MATERIAL AND METHOD: We have reviewed all medical charts of patients that underwent Dx/HA treatment from 2006 to 2010. We have selected patients with initial successful treatment and more than 3 years of radiological and clinical follow-up. We have analyzed late clinical and radiological outcomes. RESULTS: One hundred and sixty children with 228 refluxing ureters underwent Dx/HA endoscopic treatment with a mean follow-up of 52.13 months. Early VCUG was performed in 215 ureters with an initial successful rate of 84.1%. The group of study was 94/215 ureters with more than 3 years of follow-up with a delayed VCUG. VUR was still resolved in 79,8% of the ureters. Clinical success rate was 91.7%. The incidence of febrile urinary tract infection in those patients with cured VUR and those with a relapsed VUR was 8 and 15%, respectively; but there were no significant differences. We have not found any variable related with relapsed VUR except those ureters that initially received 2 injections (P<.05). CONCLUSION: If our objective in the treatment of VUR is to reduce the incidence of febrile urinary tract infection it is not necessary to perform a delayed VCUG even though the long-term radiological outcomes is worse than clinical outcome.


Subject(s)
Cystography , Cystoscopy , Dextrans/therapeutic use , Hyaluronic Acid/therapeutic use , Ureteroscopy , Urethra/diagnostic imaging , Vesico-Ureteral Reflux/diagnostic imaging , Vesico-Ureteral Reflux/therapy , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Remission Induction , Retrospective Studies , Time Factors , Urination
3.
Acta pediatr. esp ; 73(1): e12-e17, ene. 2015. tab
Article in Spanish | IBECS | ID: ibc-132657

ABSTRACT

El parvovirus B19 es un virus patógeno humano. Aunque su asociación al daño renal es rara en la edad pediátrica, se han descrito algunos casos de glomerulonefritis aguda en el contexto de una infección por parvovirus B19. Describimos el caso de una niña de 12 años de edad, previamente sana, que desarrolló edemas y proteinuria. Los estudios serológicos determinaron anticuerpos IgM antiparvovirus B19. El genoma del parvovirus B19 fue detectado mediante reacción en cadena de la polimerasa. La paciente se recuperó espontáneamente, con desaparición de la proteinuria y resolución de la hipocomplementemia. La infección por parvovirus B19 se ha asociado al daño renal y es uno de los agentes etiológicos de glomerulonefritis aguda (AU)


Parvovirus B19 is a human pathogenic virus. Even if his association with renal injury is rare, recently cases of acute glomerulonephritis during the course of parvovirus B19 infection have been described. We studied a previously healthy 12-year-old girl who developed edema and proteinuria. Serological studies determined IgM antibody titers to parvovirus B19. The parvovirus B19 genome was detected by PCR. The Parvovirus B19 infection has been associated with renal injury, may be one of the etiological agents of acute glomerulonephritis (AU)


Subject(s)
Humans , Female , Child , Glomerulonephritis/etiology , Glomerulonephritis/pathology , Parvovirus B19, Human/pathogenicity , Polymerase Chain Reaction/instrumentation , Glomerulonephritis/diagnosis , Polymerase Chain Reaction/methods
4.
An. pediatr. (2003, Ed. impr.) ; 74(5): 332-335, mayo 2011. tab
Article in Spanish | IBECS | ID: ibc-90332

ABSTRACT

Introducción: Se ha descrito una asociación entre neumonía y glomerulonefritis aguda iniciándose ambos procesos de forma simultánea. Pacientes y métodos: Estudio retrospectivo de 6 pacientes ingresados en nuestro centro entre los años 2001 y 2010 con glomerulonefritis aguda asociada a neumonía concomitante, con frotis y cultivo amigdalar negativos y en ausencia de infección cutánea o episodio de neumonía anterior. Resultados: La media de edad de los pacientes al ingreso fue de 5,9 años sin diferencia de sexos. El diagnóstico de neumonía se realizó en el momento del ingreso, coincidiendo con la sintomatología nefrológica. Los síntomas más frecuentes fueron fiebre y hematuria macroscópica. Todos tuvieron un C3 (fracción C3 del complemento) bajo. En 5 de ellos se encontró una elevación significativa en la cifra de antiestreptolisinas (ASLO). En la mayoría de los casos la afectación renal fue leve a excepción de un caso de insuficiencia renal aguda con creatinina inicial de 2,77 mg/dl y filtrado glomerular de 27 ml/min/1,73m2 y 2 casos con proteinuria en rango nefrótico. Todos evolucionaron hacia la curación sin tratamiento o con mínimo tratamiento diurético o hipotensor, además de tratamiento antibiótico adecuado para su proceso neumónico, con resolución de la clínica entre 7—10 días y normalización del C3 en un período inferior a los 4 meses. Conclusiones: Aunque descrita con mucho menos frecuencia, existe asociación entre glomerulonefritis aguda y presencia concomitante de neumonía. Las ASLO, en nuestra serie, no son específicas de infección por Streptococcus pyogenes. El pronóstico respiratorio y renal fue favorable en todos los casos (AU)


Introduction: There is an association between pneumonia and acute glomerulonephritis. Both processes start simultaneously. Patients and methods: A retrospective study of 6 patients admitted to our centre between 2001 and 2010 with acute glomeruolonephritis associated with pneumonia. The result of the smear and tonsil culture was negative and there was an absence of cutaneous infection. Results: The average age of the patients on admission was 5.9 years with no differences in sex. The diagnosis for pneumonia was made at the time of admission, coinciding with the glomerular symptoms. The most frequent symptoms were fever and macrohaematuria. All had low levels of C3. A significant increase in ASLO was found in 5 cases. The majority of the cases had mild symptoms with the exception of one case of acute renal failure with an initial creatinine of 2.77 mg/dL and glomerular filtration rate of 27 ml/min/1.73m2, and two cases with proteinuria in the nephrotic range. All of them progressed satisfactorily without treatment or with minimum diuretic or hypotensive treatment in addition to the appropriate antibiotic treatment with clinical resolution in 7 to 10 days, and C3 returning to normal within a period of less than 4months. Conclusions: There is an association between acute glomerulonephritis and pneumonia, although it is very uncommon. The ASLOs in our series are not specific for Streptoccocus. Pyogenes infection. The respiratory and renal prognosis was favourable in all cases (AU)


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Glomerulonephritis/etiology , Pneumonia/complications , Infections/complications , Acute Disease , Retrospective Studies , Streptococcus pyogenes/pathogenicity , Streptococcal Infections/complications
5.
An Pediatr (Barc) ; 74(5): 332-5, 2011 May.
Article in Spanish | MEDLINE | ID: mdl-21334269

ABSTRACT

INTRODUCTION: There is an association between pneumonia and acute glomerulonephritis. Both processes start simultaneously. PATIENTS AND METHODS: A retrospective study of 6 patients admitted to our centre between 2001 and 2010 with acute glomeruolonephritis associated with pneumonia. The result of the smear and tonsil culture was negative and there was an absence of cutaneous infection. RESULTS: The average age of the patients on admission was 5.9 years with no differences in sex. The diagnosis for pneumonia was made at the time of admission, coinciding with the glomerular symptoms. The most frequent symptoms were fever and macrohaematuria. All had low levels of C3. A significant increase in ASLO was found in 5 cases. The majority of the cases had mild symptoms with the exception of one case of acute renal failure with an initial creatinine of 2.77mg/dL and glomerular filtration rate of 27ml/min/1.73m(2), and two cases with proteinuria in the nephrotic range. All of them progressed satisfactorily without treatment or with minimum diuretic or hypotensive treatment in addition to the appropriate antibiotic treatment with clinical resolution in 7 to 10 days, and C3 returning to normal within a period of less than 4 months. CONCLUSIONS: There is an association between acute glomerulonephritis and pneumonia, although it is very uncommon. The ASLOs in our series are not specific for Streptoccocus. pyogenes infection. The respiratory and renal prognosis was favourable in all cases.


Subject(s)
Glomerulonephritis/complications , Pneumonia/complications , Acute Disease , Child , Child, Preschool , Female , Humans , Male , Retrospective Studies
7.
Acta pediatr. esp ; 68(10): 493-496, nov. 2010. tab
Article in Spanish | IBECS | ID: ibc-85887

ABSTRACT

Objetivos: Presentar nuestra experiencia sobre biopsias renales percutáneas guiadas ecográficamente en pacientes en edad pediátrica desde que se instauró dicha técnica en nuestro hospital, y valorar la correlación clínica/anatomopatológica y las complicaciones de la misma. Pacientes y métodos: Estudio retrospectivo de 180 biopsias renales percutáneas guiadas ecográficamente realizadas a un total de 164 pacientes (de 6 meses-18 años de edad) durante un periodo de 15 años. El protocolo de la biopsia incluye su realización en el quirófano mediante sedación y una ecografía a las 24 horas. Resultados: El motivo más frecuente de su realización fue la presencia de un síndrome nefrótico cortico dependiente/resistente (29,4%), seguido de la proteinuria de diverso rango con presencia de hematuria. El diagnóstico anatomopatológico más habitual fue la glomérulo nefritis mesangial por IgA (26,1%), seguido de cambios glomerulares mínimos, confirmándose en la mayoría de los casos la sospecha clínica. Únicamente se detectó una complicación grave (hematoma renal/hipotensión arterial)en un paciente de riesgo. Conclusiones: En nuestra experiencia, la biopsia renal percutánea es un método diagnóstico fiable y seguro, independientemente de la edad (AU)


Objectives: We present our experience on ultrasound guided percutaneous renal biopsies in pediatric patients from the beginning that this technique was established in our hospital, to value the clinical/anatomo pathologic correlation as well as the complications of the technique. Patients and methods: Retrospective study of 180 ultrasound guided percutaneous renal biopsies over a total of 164 patients (aged from 6 months to 18 years) in a period of 15 years. The protocol biopsy includes its carrying out in the operating room by means of sedation and also the realization of an ultrasound after 24 hours. Results: The most frequent reason for doing the biopsy was the presence of a corticoid dependent/resistant nephrotic syndrome (29.4%) followed by different levels of. The most frequent anatomopathological diagnostic was glomerulonephritis with Ig A mesangial deposits (26.1%) followed by minimal glomerular changes, confirming in the majority of the cases the initial clinical suspicion. Only in one case a severe complication was detected (renal hematoma/arterial hypotension) in a high-risk patient. Conclusions: In our experience, the percutaneous renal biopsies are a reliable and a safe diagnostic method regardless of age (AU)


Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Biopsy/instrumentation , Biopsy/methods , Biopsy , Ultrasonography/instrumentation , Ultrasonography/methods , Ultrasonography , Kidney/anatomy & histology , Kidney/pathology , Nephrotic Syndrome/complications , Nephrotic Syndrome/diagnosis , Nephrotic Syndrome/pathology , Proteinuria/complications , Proteinuria/diagnosis , Glomerulonephritis, IGA/complications , Glomerulonephritis, IGA/diagnosis
8.
Hipertens. riesgo vasc ; 26(3): 122-125, mayo-jun. 2009. graf
Article in Spanish | IBECS | ID: ibc-117989

ABSTRACT

Introducción: Durante el ejercicio se produce una elevación fisiológica de la presión arterial. Algunos sujetos previamente normotensos presentan grandes incrementos con el ejercicio, lo que podría ser un factor pronóstico adverso.Casos clínicos: Dos varones de 15 y 16 años, sin antecedentes personales de interés, remitidos por pérdida de conciencia de minutos de duración, en el primer caso, con recuperación espontánea mientras entrenaba al baloncesto y, en el segundo, con cefalea importante desencadenada durante un partido de fútbol. Se constataron cifras de presión > P99 en ambos. La exploración física era normal. Se realizaron determinaciones en condiciones de reposo, que mostraron intervalos de normalidad. Los hallazgos analíticos, función renal, metabólica y hormonal fueron normales. No se encontraron anomalías en la eco-Doppler. Se descartó afección de órganos diana. La monitorización ambulatoria de la presión arterial mostró máximos de presión > P99 coincidiendo con la realización de ejercicio; las demás lecturas estaban dentro de la normalidad. Se suprimió el ejercicio físico intenso sin requerir otro tipo de medidas.Conclusiones: Valorar la aparición de hipertensión arterial en adolescentes que practican deporte, introducir la monitorización ambulatoria de la presión arterial como cribado en revisiones médico-deportivas y suprimir el esfuerzo como única medida terapéutica(AU)


Introduction: Exercise produces a physiological increase of the blood pressure. Some previously normotensive subjects have significant increases with exercise, which could be an adverse prognostic factor.Clinical cases: Two male subjects, 15 and 16 years old, with no personal background of interest, were referred. The first one was due to loss of consciousness for several minutes with spontaneous recovery while practicing basketball. The second case was for a strong headache that occurred while playing soccer. Blood pressure values for both were > P99 and their physical examinations were normal. Tests performed at rest showed normal ranges. The laboratory findings, renal and metabolic function and hormones were normal. There were no abnormalities on the echo-Doppler. Involvement of target organs was ruled out. Ambulatory blood pressure monitoring showed tension peaks > P99, coinciding with exercise, the remaining readings being within normality. Intense physical exercise was discontinued, without requiring any other type of actions.Conclusions: Introducing ambulatory blood pressure monitoring as screening in medicalsports check-ups and suppression of exercise as the only therapeutic measures should be evaluated when faced with arterial hypertension in adolescents who practice sports(AU)


Subject(s)
Humans , Male , Adolescent , Hypertension/physiopathology , Physical Exertion , Hypertrophy, Left Ventricular/epidemiology , Risk Factors , Mass Screening , Cardiovascular Diseases/epidemiology , Sports
9.
An Pediatr (Barc) ; 69(4): 297-303, 2008 Oct.
Article in Spanish | MEDLINE | ID: mdl-18928695

ABSTRACT

OBJECTIVES: Our objectives were to determine epidemiology, clinical and laboratory characteristics of patients with haemolytic-uraemic syndrome (HUS) treated in our centre, to describe renal and extra-renal complications and the treatment required and to relate our findings with the existing bibliography. METHODS: We performed a 33-year retrospective review. We included all patients diagnosed with HUS and monitored in our hospital from January 1974 to August 2007. Clinical histories and imaging studies were reviewed. RESULTS: A total of 58 patients were included in our study, with a mean age of 2 years 11 months and most of them were admitted to hospital in summer. Familial hypocomplementaemia was present in one case. A total of 48 patients presented with typical HUS (with diarrhoea D+ HUS). Salmonella enteritidis and Escherichia coli O157:H7 were isolated from those patients. While 7 cases presented with atypical HUS (without diarrhoea, D- HUS), most of them associated with a respiratory tract infection due to Streptococcus. In one case platelet count was normal. Kidney biopsy was performed in 18 patients and 25 cases underwent peritoneal dialysis. As regards complications, one child with D+ HUS experienced renal cortical necrosis and required kidney transplant, while in the D-HUS group, the patient with familial hypocomplementaemia had severe hypertension. CONCLUSIONS: a) Incidence of HUS in our environment is low. b) HUS can be present even with a normal platelet count. c) We had one case of HUS in a patient with familial hypocomplementaemia who experienced severe hypertension. d) In our group of patients, the course of the disease was not influenced by the white blood cell counts, decreased diuresis or hypocomplementaemia.


Subject(s)
Hemolytic-Uremic Syndrome , Adolescent , Child , Child, Preschool , Female , Hemolytic-Uremic Syndrome/diagnosis , Hemolytic-Uremic Syndrome/epidemiology , Hemolytic-Uremic Syndrome/therapy , Humans , Infant , Longitudinal Studies , Male , Retrospective Studies
10.
An. pediatr. (2003, Ed. impr.) ; 69(4): 297-303, oct. 2008. ilus, tab
Article in Es | IBECS | ID: ibc-67679

ABSTRACT

Objetivos: Nuestros objetivos han sido determinar aspectos epidemiológicos, formas clínicas y analíticas de los pacientes con síndrome hemolítico-urémico (SHU) tratados en nuestros centros, así como describir las complicaciones renales y extrarrenales, el tipo de tratamiento requerido y relacionar nuestros casos con la bibliografía actual. Métodos: Efectuamos una revisión retrospectiva de la historia clínica, analítica y estudios de diagnóstico por imagen de los pacientes con diagnóstico de SHU, atendidos desde enero de 1974 hasta agosto de 2007, es decir, durante los últimos 33 años. Resultados: Un total de 58 pacientes fueron incluidos en nuestro estudio, con una edad media de 2 años y 11 meses; de ellos, estaban ingresados en verano 34 niños. Destaca la presencia de hipocomplementemia familiar en un caso. Con SHU típico (diarrea positivo [D+]) aparecieron 48 casos en los que se aislaron Salmonella enteritidis y Escherichia coli 0157:H7. Con SHU atípico (diarrea negativo [D-]) se contabilizaron 7 casos, y entre las causas destacaban procesos respiratorios de etiología estreptocócica. El recuento plaquetario fue normal en un caso. De los procedimientos empleados cabe destacar que se realizó biopsia renal en 18 pacientes y diálisis peritoneal en 25 casos. Entre las complicaciones se encontraron: en el grupo D+, un caso de necrosis cortical que requirió trasplante renal y en el grupo D-, un paciente con SHU familiar, hipocomplementemia e hipertensión arterial maligna. Conclusiones: Hemos llegado a las siguientes conclusiones: a) la enfermedad presenta una baja incidencia en nuestro medio; b) se ha detectado un caso con plaquetas normales; c) un paciente presentó SHU familiar recurrente con hipocomplementemia e hipertensión arterial grave, y d) indicadores como la leucocitosis, la oligoanuria o la hipocomplementemia no influyeron en el curso de la enfermedad (AU)


Objectives: Our objectives were to determine epidemiology, clinical and laboratory characteristics of patients with haemolytic-uraemic syndrome (HUS) treated in our centre, to describe renal and extra-renal complications and the treatment required and to relate our findings with the existing bibliography. Methods: We performed a 33-year retrospective review. We included all patients diagnosed with HUS and monitored in our hospital from January 1974 to August 2007. Clinical histories and imaging studies were reviewed. Results: A total of 58 patients were included in our study, with a mean age of 2 years 11 months and most of them were admitted to hospital in summer. Familial hypocomplementaemia was present in one case. A total of 48 patients presented with typical HUS (with diarrhoea D+ HUS). Salmonella enteritidis and Escherichia coli O157:H7 were isolated from those patients. While 7 cases presented with atypical HUS (without diarrhoea, D- HUS), most of them associated with a respiratory tract infection due to Streptococcus. In one case platelet count was normal. Kidney biopsy was performed in 18 patients and 25 cases underwent peritoneal dialysis. As regards complications, one child with D+ HUS experienced renal cortical necrosis and required kidney transplant, while in the D-HUS group, the patient with familial hypocomplementaemia had severe hypertension. Conclusions: a) Incidence of HUS in our environment is low. b) HUS can be present even with a normal platelet count. c) We had one case of HUS in a patient with familial hypocomplementaemia who experienced severe hypertension. d) In our group of patients, the course of the disease was not influenced by the white blood cell counts, decreased diuresis or hypocomplementaemia (AU)


Subject(s)
Humans , Male , Female , Child, Preschool , Infant , Hemolytic-Uremic Syndrome/complications , Hemolytic-Uremic Syndrome/diagnosis , Hemolytic-Uremic Syndrome/epidemiology , Acute Kidney Injury/complications , Acute Kidney Injury/diagnosis , Thrombocytopenia/complications , Thrombocytopenia/diagnosis , Leukocytosis/complications , Leukocytosis/diagnosis , Peritoneal Dialysis/methods , Hematuria/complications , Hematuria/diagnosis , Thrombocytopenia/therapy , Leukocytosis/epidemiology , Signs and Symptoms , Longitudinal Studies , Hypertension/complications , Anemia, Hemolytic/complications
13.
An Pediatr (Barc) ; 66(3): 290-3, 2007 Mar.
Article in Spanish | MEDLINE | ID: mdl-17349256

ABSTRACT

Schönlein-Henoch purpura is a systemic vasculitis due to IgA-mediated hypersensitivity, almost exclusively affecting the pediatric age group. Long-term prognosis is mainly conditioned by renal involvement, which can appear at onset or during the course of the disease. To evaluate renal involvement, 764 patients with Schönlein-Henoch purpura were retrospectively reviewed. Of these, 153 (20 %) had renal involvement, the most frequent form of presentation being non-nephrotic hematuria/proteinuria (67 patients) followed by isolated hematuria (41 patients). Renal biopsy was performed in 39 patients, and the most frequent pathological findings were diffuse mesangial proliferation with IgA deposits and less than 50 % of crescentic glomeruli. Treatment was not curative. Three patients (2 %) progressed to end-stage renal failure and required renal transplantation. One patient died. Notably, two of the patients who underwent renal transplantation had disease recurrence. We stress that nephropathy is usually benign and that it requires long-term follow-up.


Subject(s)
IgA Vasculitis/epidemiology , Kidney Failure, Chronic/epidemiology , Anti-Inflammatory Agents/therapeutic use , Biopsy , Child , Cyclophosphamide/therapeutic use , Female , Humans , IgA Vasculitis/drug therapy , IgA Vasculitis/immunology , Immunoglobulin A/immunology , Immunosuppressive Agents/therapeutic use , Incidence , Kidney/pathology , Kidney Failure, Chronic/pathology , Male , Methylprednisolone/therapeutic use , Retrospective Studies
14.
An. pediatr. (2003, Ed. impr.) ; 66(3): 290-293, mar. 2007. ilus, tab
Article in Es | IBECS | ID: ibc-054384

ABSTRACT

La púrpura de Schönlein-Henoch es una vasculitis sistémica por hipersensibilidad mediada por inmunoglobulina A (IgA) que afecta casi exclusivamente a la edad pediátrica. La afectación renal que puede presentarse desde su inició o bien posteriormente es la que condiciona la mayoría de las veces el pronóstico a largo plazo. Con el objetivo de evaluar la afectación renal se procedió al estudio retrospectivo de 764 pacientes afectados de púrpura de Schönlein-Henoch. De ellos, 153 (20 %) presentaron afectación renal siendo la forma de presentación más frecuente la hematuria/proteinuria no nefrótica (67 pacientes) seguida de la hematuria aislada (41 pacientes). Se efectuó biopsia renal en un total de 39 pacientes siendo el hallazgo anatomopatológico más frecuente la proliferación mesangial difusa con depósitos de IgA y menos de un 50 % de semilunas. Los tratamientos efectuados no fueron determinantes por lo que respecta a la evolución final. Tres pacientes (2 %) evolucionaron a insuficiencia renal terminal precisando trasplante renal. Un paciente falleció. Hay que destacar la reaparición de la enfermedad en dos de los pacientes trasplantados. Se remarca la evolución generalmente benigna de la nefropatía y la necesidad de un seguimiento a largo plazo de la misma


Schönlein-Henoch purpura is a systemic vasculitis due to IgA-mediated hypersensitivity, almost exclusively affecting the pediatric age group. Long-term prognosis is mainly conditioned by renal involvement, which can appear at onset or during the course of the disease. To evaluate renal involvement, 764 patients with Schönlein-Henoch purpura were retrospectively reviewed. Of these, 153 (20 %) had renal involvement, the most frequent form of presentation being non-nephrotic hematuria/proteinuria (67 patients) followed by isolated hematuria (41 patients). Renal biopsy was performed in 39 patients, and the most frequent pathological findings were diffuse mesangial proliferation with IgA deposits and less than 50 % of crescentic glomeruli. Treatment was not curative. Three patients (2 %) progressed to end-stage renal failure and required renal transplantation. One patient died. Notably, two of the patients who underwent renal transplantation had disease recurrence. We stress that nephropathy is usually benign and that it requires long-term follow-up


Subject(s)
Male , Female , Child , Humans , Kidney Diseases/complications , Kidney Diseases/diagnosis , Kidney Diseases/therapy , IgA Vasculitis/complications , IgA Vasculitis/diagnosis , Glomerulonephritis/complications , Glomerulonephritis/diagnosis , Retrospective Studies , Immunoglobulins/analysis , Hematuria/complications , Proteinuria/complications , Proteinuria/diagnosis
15.
Rev. esp. pediatr. (Ed. impr.) ; 60(2): 152-153, mar. 2004.
Article in Es | IBECS | ID: ibc-37730

ABSTRACT

No hemos encontrado ningún caso descrito en la literatura de síndrome nefrótico y enfermedad celíaca. Presentamos 5 pacientes diagnosticados de síndrome nefrótico durante los últimos cinco años a 4 de los cuales se les había diagnosticado previamente una enfermedad celíaca, siendo el último de ellos diagnosticado al solicitarse los marcadores de celiaquía en el momento del debut del síndrome nefrótico. La enfermedad celíaca no influyó en el pronóstico ni en la evolución del síndrome nefrótico. No hemos encontrado explicación para el aumento de la asociación de las dos enfermedades en nuestra serie Destacamos la necesidad de incluir los marcadores de celiaquía en el estudio de los pacientes afectos de síndrome nefrótico (AU)


Subject(s)
Female , Child, Preschool , Male , Child , Humans , Nephrotic Syndrome/complications , Celiac Disease/complications , Retrospective Studies , Biopsy , Nephrotic Syndrome/pathology
17.
Arch Esp Urol ; 54(2): 168-70, 2001 Mar.
Article in Spanish | MEDLINE | ID: mdl-11341123

ABSTRACT

OBJECTIVE: To report two additional cases of Schönlein-Henoch purpura that developed acute scrotum. METHODS: Two patients with Schönlein-Henoch purpura that developed acute scrotum in the course of the disease are presented. The literature is briefly reviewed and discussed. RESULTS/CONCLUSIONS: Schönlein-Henoch purpura is a systemic vasculitis with involvement of the genital area in 15% of the cases and must be distinguished from testicular torsion. The clinical features, the findings at physical examination and scrotal ultrasound evaluation should suffice to make the correct diagnosis and avoid surgery. However, if the findings are inconclusive, techniques using isotopes and/or echo-Doppler can be utilized. If these are not available, exploratory scrototomy should not be delayed. Excellent response is achieved with steroid therapy.


Subject(s)
IgA Vasculitis/complications , Pain/etiology , Scrotum , Acute Disease , Child , Child, Preschool , Genital Diseases, Male/etiology , Humans , Male
18.
Acta pediatr. esp ; 58(2): 95-97, feb. 2000. tab
Article in Es | IBECS | ID: ibc-8775

ABSTRACT

Se presenta el caso de una adolescente de 13 años que sufrió un cuadro de insuficiencia renal aguda (IRA) tras ingestión masiva de antinflamatorios no esteroideos (AINE) por intento de autólisis. El cuadro tuvo una evolución clínica favorable con tratamiento sintomático. Por otra parte, se recuerda la fisiopatología de las diferentes manifestaciones renales asociadas a ingestión de AINE. Se incide en la necesidad de incluir la ingestión de estos fármacos en el diagnóstico diferencial de una paciente pre o adolescente que se presenta con IRA de etiología no aclarada (AU)


Subject(s)
Adolescent , Female , Humans , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Acute Kidney Injury/chemically induced , Acute Kidney Injury/physiopathology , Proteinuria/etiology , Naproxen/adverse effects , Kidney Papillary Necrosis/chemically induced , Nephritis, Interstitial/chemically induced
19.
An Esp Pediatr ; 23(3): 215-8, 1985 Sep.
Article in Spanish | MEDLINE | ID: mdl-4073690

ABSTRACT

A term newborn with megacephaly and coagulation disease after a difficult delivery is reported. Images of pseudoporencephaly and hydrocephaly were seen in the scan as well as recent hemorrhages due to obstetric injury. Possibility of a prenatal intracranial hemorrhage being first cause is discussed.


Subject(s)
Brain Diseases/etiology , Cerebral Hemorrhage/complications , Cysts/etiology , Hydrocephalus/etiology , Brain/diagnostic imaging , Cerebral Hemorrhage/congenital , Humans , Infant, Newborn , Male , Tomography, X-Ray Computed
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