Impacto del componente hiperclorémico de la acidosis metabólica en el estado de hidratación y en el tratamiento de la cetoacidosis diabética / Impact of the hyperchloremic component of metabolic acidosis on the patient's hydration status and the treatment of diabetic ketoacidosis

Introducción. La cetoacidosis diabética (CAD) se caracteriza por acidosis metabólica (AM) con anión restante (AR) elevado, aunque, ocasionalmente, puede presentar hipercloremia. Se postuló que la presencia de hipercloremia inicial podría reflejar un mejor estado de hidratación; sin embargo, su prevalencia y su impacto en el tratamiento de la CAD se desconoce. Objetivos. Determinar la prevalencia de AM con componente hiperclorémico previo al inicio del tratamiento y evaluar si su presencia se asocia con mejor estado de hidratación y con menor tiempo de salida de la CAD, en comparación con los pacientes con AR elevado exclusivo. Pacientes y métodos. Se agruparon los pacientes internados con CAD (período entre enero de 2014 y junio de 2016) según presentaran, al ingresar, AM con AR elevado exclusivo o con hipercloremia y se compararon sus variables clínicas, de laboratorio y la respuesta al tratamiento. Resultados. Se incluyeron 40 pacientes -amp;#91;17 varones, mediana de edad: 14,5 años (2,4-18)-amp;#93;, 22 con AM con componente hiperclorémico (prevalencia de 55%) y 18 con AR elevado exclusivo. La presencia de hipercloremia no se asoció con mejor estado de hidratación (porcentaje de déficit de peso en ambos grupos: 4,9%; p= 0,81) ni con una respuesta terapéutica más rápida (con componente hiperclorémico: 9,5 horas; con AR elevado exclusivo: 11 horas; p= 0,64). Conclusiones. En niños con CAD, la prevalencia de AM con componente hiperclorémico fue del 55% y no se asoció con un mejor estado de hidratación ni con una salida más temprana de la descompensación metabólica.

Introduction. Diabetic ketoacidosis (DKA) is characterized by metabolic acidosis (MA) with a high anion gap (AG), although, occasionally, it can present with hyperchloremia. It has been postulated that the early presence of hyperchloremia could reflect a better hydration status; however, its prevalence and impact on DKA treatment remain unknown. Objectives. To determine the prevalence of the hyperchloremic component in MA prior to treatment and to assess whether it is associated with a better hydration status and a shorter recovery time from DKA compared to patients with high AG only. Patients and Methods. Patients hospitalized with DKA (between January 2014 and June 2016) were grouped according to whether they were admitted with MA with high AG only. or with hyperchloremia, and clinical and laboratory outcome measures and response to treatment were compared. Results. Forty patients (17 males, median age: 14.5 years -amp;#91;2.4-18-amp;#93;) were included; 22 with hyperchloremic metabolic acidosis (prevalence of 55%) and 18 with metabolic acidosis with high AG only. The presence of hyperchloremia was not associated with a better hydration status (weight loss percentage in both groups: 4.9%; p= 0.81) nor with a faster treatment response (MA with a hyperchloremic component: 9.5 hours; MA with high AG only: 11 hours; p= 0.64). Conclusions. The prevalence of MA with a hyperchloremic component among children with DKA was 55% and was not associated with a better hydration status nor with a faster recovery from the metabolic decompensation.

Impact of the hyperchloremic component of metabolic acidosis on the patient's hydration status and the treatment of diabetic ketoacidosis. / Impacto del componente hiperclorémico de la acidosis metabólica en el estado de hidratación y en el tratamiento de la cetoacidosis diabética.

INTRODUCTION: Diabetic ketoacidosis (DKA) is characterized by metabolic acidosis (MA) with a high anion gap (AG), although, occasionally, it can present with hyperchloremia. It has been postulated that the early presence of hyperchloremia could reflect a better hydration status; however, its prevalence and impact on DKA treatment remain unknown. determine the prevalence of the hyperchloremic component in MA prior to treatment and to assess whether it is associated with a better hydration status and a shorter recovery time from DKA compared to patients with high AG only. Patients and Methods. Patients hospitalized with DKA (between January 2014 and June 2016) were grouped according to whether they were admitted with MA with high AG only. or with hyperchloremia, and clinical and laboratory outcome measures and response to treatment were compared. RESULTS: Forty patients (17 males, median age: 14.5 years [2.4-18]) were included; 22 with hyperchloremic metabolic acidosis (prevalence of 55%) and 18 with metabolic acidosis with high AG only. The presence of hyperchloremia was not associated with a better hydration status (weight loss percentage in both groups: 4.9%; p= 0.81) nor with a faster treatment response (MA with a hyperchloremic component: 9.5 hours; MA with high AG only: 11 hours; p= 0.64). CONCLUSIONS: The prevalence of MA with a hyperchloremic component among children with DKA was 55% and was not associated with a better hydration status nor with a faster recovery from the metabolic decompensation.

Introducción. La cetoacidosis diabética (CAD) se caracteriza por acidosis metabólica (AM) con anión restante (AR) elevado, aunque, ocasionalmente, puede presentar hipercloremia. Se postuló que la presencia de hipercloremia inicial podría reflejar un mejor estado de hidratación; sin embargo, su prevalencia y su impacto en el tratamiento de la CAD se desconoce. Objetivos. Determinar la prevalencia de AM con componente hiperclorémico previo al inicio del tratamiento y evaluar si su presencia se asocia con mejor estado de hidratación y con menor tiempo de salida de la CAD, en comparación con los pacientes con AR elevado exclusivo. Pacientes y métodos. Se agruparon los pacientes internados con CAD (período entre enero de 2014 y junio de 2016) según presentaran, al ingresar, AM con AR elevado exclusivo o con hipercloremia y se compararon sus variables clínicas, de laboratorio y la respuesta al tratamiento. Resultados. Se incluyeron 40 pacientes [17 varones, mediana de edad: 14,5 años (2,4-18)], 22 con AM con componente hiperclorémico (prevalencia de 55%) y 18 con AR elevado exclusivo. La presencia de hipercloremia no se asoció con mejor estado de hidratación (porcentaje de déficit de peso en ambos grupos: 4,9%; p= 0,81) ni con una respuesta terapéutica más rápida (con componente hiperclorémico: 9,5 horas; con AR elevado exclusivo: 11 horas; p= 0,64). Conclusiones. En niños con CAD, la prevalencia de AM con componente hiperclorémico fue del 55% y no se asoció con un mejor estado de hidratación ni con una salida más temprana de la descompensación metabólica.

Early erythropoietin in post-diarrheal hemolytic uremic syndrome: a case-control study.

BACKGROUND: Although erythropoietin (EPO) deficiency has been reported in children with post-diarrheal hemolytic uremic syndrome (D + HUS), very limited clinical data on EPO use in this disease are currently available. In this case-control study we examined whether EPO administration would reduce the number of red blood cell (RBC) transfusions in D + HUS patients under our care. METHODS: Data from children treated exclusively with RBC transfusions (controls; n = 21) were retrospectively compared with data on those who also received EPO for the treatment of anemia (cases; n = 21). RESULTS: Both patient groups were similar in age (p = 0.9), gender (p = 0.12), weight (p = 1.00) and height (p = 0.66). Acute phase severity was also comparable, as inferred by the need for dialysis (p = 0.74), the duration of dialysis (p = 0.3), length of hospitalization (p = 0.81), presence of severe bowel (p = 1.00) or neurological injury (p = 0.69), arterial hypertension (p = 1.00) and death (p = 1.00). No differences in the hemoglobin level at admission (p = 0.51) and discharge (p = 0.28) were noted. Three children treated with EPO and two controls did not require any RBC transfusion (p = 1.00). Median number of RBC transfusions needed by cases and controls was 2 (p = 0.52). CONCLUSION: Treatment with EPO did not reduce the number of RBC transfusions in D + HUS children. Assessment of EPO efficacy in D + HUS merits further studies.

[Using Objective Structured Clinical Examination (OSCE) across different levels of pediatric training]. / Empleo del examen clínico objetivo estructurado (ECOE) en diversos niveles de educación de la pediatría.

BACKGROUND: To evaluate professional competences is the main goal of every training program; the Objective Structured Clinical Examination (OSCE) is a useful tool for this task. OBJECTIVE: We describe OSCE administration across three different levels of pediatric training (postgraduate, internship and graduate medical education). METHODS: Regarding the most common pediatric scenarios, knowledge, clinical judgment and communicational skills were evaluated. RESULTS: In the postgraduate setting OSCE was used for the last 8 years, testing 330 students, and passing 60%-82% of them. In the internship setting OSCE was used for the last 2 years, testing 12 students, and passing 84% of them. In the medical school setting OSCE was used just once, testing 15 students, and passing 93.4% of them. CONCLUSION: Despite logistic issues, OSCE could be administered across three different levels of pediatric training.

Antecedentes:Evaluar competencias profesionales es objetivo principal de todo programa de capacitación; el examen clínico objetivo estructurado (ECOE) es una herramienta útil para explorarlas. Objetivo:Describimos la implementación del ECOE en tres instancias de enseñanza de la pediatría (carrera de especialista, módulo pediatría del internado anual rotatorio, materia pediatría en el grado). Métodos: En relación con situaciones y patologías frecuentes en pediatría, se evaluaron conocimiento aplicado, juicio clínico y habilidad comunicacional. Resultados: En el posgrado el ECOE se aplica desde hace 8 años, examinando 330 alumnos, con 60%-82% de aprobación. En el Internado Anual Rotatorio el ECOE se emplea desde hace 2 años, examinando 12 alumnos, con 84% de aprobación. En el grado el ECOE se empleó sólo en una oportunidad, examinando 15 alumnos, con 93,4% de aprobación. Conclusión:En nuestra experiencia, a pesar de desafíos logísticos, la implementación del ECOE fue factible en distintas instancias de enseñanza de la pediatría.

Hipercalciuria idiopática en niños con infección del tracto urinario / Idiopathic hypercalciuria in children with urinary tract infection

Introducción. La hipercalciuria idiopática (HI) predispone al desarrollo de infección del tracto urinario (ITU); sin embargo, hay escasa información local sobre dicha asociación. Nuestros objetivos fueron estimar la prevalencia de HI en niños con ITU y evaluar si esta difería según la presencia o no de reflujo vesicoureteral (RVU). Complementariamente, analizamos la asociación entre HI y la ingesta de sal. Población y métodos. Determinamos la calciuria a pacientes menores de 18 años con ITU estudiada (ecografía y cistouretrografía miccional) y ausencia de causas secundarias de hipercalciuria. Consideramos HI al cociente calcio/creatinina > 0,8; 0,6; 0,5 y 0,2 en niños de 0-6 meses, 7-12 meses, 12-24 meses y en los mayores de 2 años, respectivamente; e ingesta elevada de sodio, al cociente sodio/potasio urinario > 2,5. Resultados. En 136 pacientes (87 niñas, mediana de edad 3 años), la prevalencia de HI fue de 20%. Los pacientes con (n= 54) y sin (n= 82) RVU fueron similares en género, peso, talla, edad al diagnóstico y al momento del estudio, características clínicas (hematuria, nefrolitiasis, dolor cólico y recurrencia de ITU), antecedentes familiares de nefrolitiasis y en la prevalencia de HI (26% vs. 16%, p= 0,24). Los niños hipercalciúricos presentaron ingesta elevada de sodio más frecuentemente que los normocalciúricos (76% vs. 46%, p= 0,007). Conclusiones. La prevalencia de HI en niños con ITU fue alta (20%) y no difirió entre los pacientes con y sin RVU. Sería recomendable la búsqueda de HI en los niños con ITU, independientemente de la presencia o no de RVU.

Introduction. Idiopathic hypercalciuria (IH) predisposes to urinary tract infections (UTIs); however, there is scarce local information regarding such association. Our objectives were to estimate IH prevalence in children with UTI and to assess whether there were differences in relation to the presence or absence of vesicoureteral reflux (VUR). Additionally, the association between IH and salt intake was studied. Population and Methods. Calciuria was determined in patients younger than 18 years old on whom UTI had been studied (ultrasound and voiding cystourethrogram), and who had no secondary causes of hypercalciuria. IH was defined as a calcium to creatinine ratio of >0.8, 0.6, 0.5 and 0.2 in children aged 0 to 6 months old, 7 to12 months old, 12 to 24 months old and older than 2 years old, respectively; and a high sodium intake with a urinary sodium to potassium ratio of >2.5. Results. IH prevalence among 136 patients (87 girls, median age: 3 years old) was 20%. Patients with VUR (n= 54) and without VUR (n= 82) had similar characteristics in terms of sex, weight, height, age at diagnosis and age at the time of the study, and clinical features (hematuria, nephrolithiasis, colicky pain, and recurrent UTI), family history of kidney stone formation, and IH prevalence (26% versus 16%, p= 0.24). A high sodium intake was more frequently observed in children with hypercalciuria than in those with normal urine calcium levels (76% versus 46%, p= 0.007). Conclusions. IH prevalence in children with UTI was high (20%), with no differences observed between patients with and without VUR. As a recommendation, the presence of IH should be detected in children with UTI, regardless of VUR presence or absence.

Hipercalciuria idiopática en niños con infección del tracto urinario / Idiopathic hypercalciuria in children with urinary tract infection

Introducción. La hipercalciuria idiopática (HI) predispone al desarrollo de infección del tracto urinario (ITU); sin embargo, hay escasa información local sobre dicha asociación. Nuestros objetivos fueron estimar la prevalencia de HI en niños con ITU y evaluar si esta difería según la presencia o no de reflujo vesicoureteral (RVU). Complementariamente, analizamos la asociación entre HI y la ingesta de sal. Población y métodos. Determinamos la calciuria a pacientes menores de 18 años con ITU estudiada (ecografía y cistouretrografía miccional) y ausencia de causas secundarias de hipercalciuria. Consideramos HI al cociente calcio/creatinina > 0,8; 0,6; 0,5 y 0,2 en niños de 0-6 meses, 7-12 meses, 12-24 meses y en los mayores de 2 años, respectivamente; e ingesta elevada de sodio, al cociente sodio/potasio urinario > 2,5. Resultados. En 136 pacientes (87 niñas, mediana de edad 3 años), la prevalencia de HI fue de 20%. Los pacientes con (n= 54) y sin (n= 82) RVU fueron similares en género, peso, talla, edad al diagnóstico y al momento del estudio, características clínicas (hematuria, nefrolitiasis, dolor cólico y recurrencia de ITU), antecedentes familiares de nefrolitiasis y en la prevalencia de HI (26% vs. 16%, p= 0,24). Los niños hipercalciúricos presentaron ingesta elevada de sodio más frecuentemente que los normocalciúricos (76% vs. 46%, p= 0,007). Conclusiones. La prevalencia de HI en niños con ITU fue alta (20%) y no difirió entre los pacientes con y sin RVU. Sería recomendable la búsqueda de HI en los niños con ITU, independientemente de la presencia o no de RVU.(AU)

Introduction. Idiopathic hypercalciuria (IH) predisposes to urinary tract infections (UTIs); however, there is scarce local information regarding such association. Our objectives were to estimate IH prevalence in children with UTI and to assess whether there were differences in relation to the presence or absence of vesicoureteral reflux (VUR). Additionally, the association between IH and salt intake was studied. Population and Methods. Calciuria was determined in patients younger than 18 years old on whom UTI had been studied (ultrasound and voiding cystourethrogram), and who had no secondary causes of hypercalciuria. IH was defined as a calcium to creatinine ratio of >0.8, 0.6, 0.5 and 0.2 in children aged 0 to 6 months old, 7 to12 months old, 12 to 24 months old and older than 2 years old, respectively; and a high sodium intake with a urinary sodium to potassium ratio of >2.5. Results. IH prevalence among 136 patients (87 girls, median age: 3 years old) was 20%. Patients with VUR (n= 54) and without VUR (n= 82) had similar characteristics in terms of sex, weight, height, age at diagnosis and age at the time of the study, and clinical features (hematuria, nephrolithiasis, colicky pain, and recurrent UTI), family history of kidney stone formation, and IH prevalence (26% versus 16%, p= 0.24). A high sodium intake was more frequently observed in children with hypercalciuria than in those with normal urine calcium levels (76% versus 46%, p= 0.007). Conclusions. IH prevalence in children with UTI was high (20%), with no differences observed between patients with and without VUR. As a recommendation, the presence of IH should be detected in children with UTI, regardless of VUR presence or absence.(AU)

Idiopathic hypercalciuria in children with urinary tract infection.

INTRODUCTION: Idiopathic hypercalciuria (IH) predisposes to urinary tract infections (UTIs); however, there is scarce local information regarding such association. Our objectives were to estimate IH prevalence in children with UTI and to assess whether there were differences in relation to the presence or absence of vesicoureteral reflux (VUR). Additionally, the association between IH and salt intake was studied. POPULATION AND METHODS: Calciuria was determined in patients younger than 18 years old on whom UTI had been studied (ultrasound and voiding cystourethrogram), and who had no secondary causes of hypercalciuria. IH was defined as a calcium to creatinine ratio of >0.8, 0.6, 0.5 and 0.2 in children aged 0 to 6 months old, 7 to12 months old, 12 to 24 months old and older than 2 years old, respectively; and a high sodium intake with a urinary sodium to potassium ratio of >2.5. RESULTS: IH prevalence among 136 patients (87 girls, median age: 3 years old) was 20%. Patients with VUR (n= 54) and without VUR (n= 82) had similar characteristics in terms of sex, weight, height, age at diagnosis and age at the time of the study, and clinical features (hematuria, nephrolithiasis, colicky pain, and recurrent UTI), family history of kidney stone formation, and IH prevalence (26% versus 16%, p= 0.24). A high sodium intake was more frequently observed in children with hypercalciuria than in those with normal urine calcium levels (76% versus 46%, p= 0.007). CONCLUSIONS: IH prevalence in children with UTI was high (20%), with no differences observed between patients with and without VUR. As a recommendation, the presence of IH should be detected in children with UTI, regardless of VUR presence or absence.

Laboratory predictors of acute dialysis in hemolytic uremic syndrome.

BACKGROUND: Strict guidelines on use of dialysis in children with post-diarrheal hemolytic uremic syndrome (D + HUS) are lacking. This study investigated laboratory predictors of acute dialysis because they are more objective than clinical features. Added to this, given that urine output is also an objective parameter, its ability to predict dialysis requirements was also investigated. METHODS: Out of 153 D + HUS children reviewed, 88 received dialysis and 65 did not. Initial laboratory parameters and diuresis between both groups were analyzed. RESULTS: Dialyzed patients had higher creatinine, urea, alanine aminotransferase, hematocrit and leukocyte count; and lower sodium, bicarbonate, and pH compared to non-dialyzed ones. Serum creatinine was the only independent predictor (P = 0.003) of dialysis; therefore, its ability to predict dialysis was estimated on receiver operating characteristic (ROC) curve analysis and using the Acute Kidney Injury Network (AKIN) staging system. Area under the ROC curve was 0.92 (95% confidence interval [95%CI]: 0.83-1) with a creatinine cut-off of 1.25 mg/dL (sensitivity, 100%; specificity, 76.5%) for children <1 year, and 0.93 (95%CI: 0.88-0.98) with a threshold of 2 mg/dL (sensitivity, 91%; specificity, 87.5%) for older children. AKIN stage 3 at admission predicted dialysis with a sensitivity of 92% and specificity of 84.2%. Urine output had the highest accuracy for dialysis prediction (sensitivity, 100%; specificity, 95.3%). CONCLUSIONS: Initial serum creatinine concentration was the best laboratory predictor of dialysis, but the first 24 h diuresis was even better for this purpose. But, given that serum creatinine is an immediate available parameter, the cut-offs identified may label D + HUS children who will probably need dialysis, prompting early referral to centers able to provide dialysis.

Empleo del examen clínico objetivo estructurado (ECOE) en diversos niveles de educación de la pediatría / [Using Objective Structured Clinical Examination (OSCE) across different levels of pediatric training].

BACKGROUND: To evaluate professional competences is the main goal of every training program; the Objective Structured Clinical Examination (OSCE) is a useful tool for this task. OBJECTIVE: We describe OSCE administration across three different levels of pediatric training (postgraduate, internship and graduate medical education). METHODS: Regarding the most common pediatric scenarios, knowledge, clinical judgment and communicational skills were evaluated. RESULTS: In the postgraduate setting OSCE was used for the last 8 years, testing 330 students, and passing 60

of them. In the internship setting OSCE was used for the last 2 years, testing 12 students, and passing 84

of them. In the medical school setting OSCE was used just once, testing 15 students, and passing 93.4

of them. CONCLUSION: Despite logistic issues, OSCE could be administered across three different levels of pediatric training.

Idiopathic hypercalciuria in children with urinary tract infection. / Idiopathic hypercalciuria in children with urinary tract infection.

INTRODUCTION: Idiopathic hypercalciuria (IH) predisposes to urinary tract infections (UTIs); however, there is scarce local information regarding such association. Our objectives were to estimate IH prevalence in children with UTI and to assess whether there were differences in relation to the presence or absence of vesicoureteral reflux (VUR). Additionally, the association between IH and salt intake was studied. POPULATION AND METHODS: Calciuria was determined in patients younger than 18 years old on whom UTI had been studied (ultrasound and voiding cystourethrogram), and who had no secondary causes of hypercalciuria. IH was defined as a calcium to creatinine ratio of >0.8, 0.6, 0.5 and 0.2 in children aged 0 to 6 months old, 7 to12 months old, 12 to 24 months old and older than 2 years old, respectively; and a high sodium intake with a urinary sodium to potassium ratio of >2.5. RESULTS: IH prevalence among 136 patients (87 girls, median age: 3 years old) was 20

. Patients with VUR (n= 54) and without VUR (n= 82) had similar characteristics in terms of sex, weight, height, age at diagnosis and age at the time of the study, and clinical features (hematuria, nephrolithiasis, colicky pain, and recurrent UTI), family history of kidney stone formation, and IH prevalence (26

versus 16

, p= 0.24). A high sodium intake was more frequently observed in children with hypercalciuria than in those with normal urine calcium levels (76

versus 46

, p= 0.007). CONCLUSIONS: IH prevalence in children with UTI was high (20

), with no differences observed between patients with and without VUR. As a recommendation, the presence of IH should be detected in children with UTI, regardless of VUR presence or absence.

Empleo del examen clínico objetivo estructurado (ECOE) en diversos niveles de educación de la pediatría. / [Using Objective Structured Clinical Examination (OSCE) across different levels of pediatric training].

BACKGROUND: To evaluate professional competences is the main goal of every training program; the Objective Structured Clinical Examination (OSCE) is a useful tool for this task. OBJECTIVE: We describe OSCE administration across three different levels of pediatric training (postgraduate, internship and graduate medical education). METHODS: Regarding the most common pediatric scenarios, knowledge, clinical judgment and communicational skills were evaluated. RESULTS: In the postgraduate setting OSCE was used for the last 8 years, testing 330 students, and passing 60

-82

of them. In the internship setting OSCE was used for the last 2 years, testing 12 students, and passing 84

of them. In the medical school setting OSCE was used just once, testing 15 students, and passing 93.4

of them. CONCLUSION: Despite logistic issues, OSCE could be administered across three different levels of pediatric training.

Acute kidney injury in critically ill children: incidence and risk factors for mortality.

INTRODUCTION: Acute kidney injury is a common complication associated with an increase in mortality in children who require intensive care. The objective of this study was to determine the incidence of acute kidney injury and identify risk factors for mortality in critically ill patients hospitalized in our facility. PATIENTS AND METHODS: This was a prospective and observational study conducted at the Intensive Care Unit (ICU) of Hospital Pedro de Elizalde between 2005 and 2009. All patients with acute kidney injury were included, and those with chronic renal failure, prerenal acute kidney injury, hepatorenal syndrome, newborn infants, and postoperative cardiovascular surgery patients were excluded. The sample was divided into survivors and deceased patients so as to identify risk factors for mortality using univariate and multivariate analyses, taking their clinical characteristics as predictive variable, and death at the ICU as the outcome variable. RESULTS: Out of 1496 patients, 66 developed acute kidney injury (4.4%). The cause was secondary in 72.8% of cases, and due to primary kidney disease in 27.2% of cases. Mortality rate was 44% (29 patients). The univariate analysis showed that the presence of anuria (p= 0.0003; OR: 7.01; 95% CI: 2.3-21.35) and the need of dialysis (p= 0.0009; OR: 6.35; 95% CI: 2.03-9.88) were signifcantly higher in deceased patients. The multiple regression analysis identifed that the need of dialysis (p = 0.0002; OR: 5.94; 95% CI: 1.85-19.04) was an independent risk factor for mortality. CONCLUSIONS: The incidence of acute kidney injury in critically ill children was 4.4%, and the need of dialysis was an independent predictor of mortality.

Acute kidney injury in critically ill children: incidence and risk factors for mortality / Daño renal agudo en niños críticos: incidencia y factores de riesgo de mortalidad

Introduction. Acute kidney injury is a common complication associated with an increase in mortality in children who require intensive care. The objective of this study was to determine the incidence of acute kidney injury and identify risk factors for mortality in critically ill patients hospitalized in our facility. Patients and Methods. This was a prospective and observational study conducted at the Intensive Care Unit (ICU) of Hospital Pedro de Elizalde between 2005 and 2009. All patients with acute kidney injury were included, and those with chronic renal failure, prerenal acute kidney injury, hepatorenal syndrome, newborn infants, and postoperative cardiovascular surgery patients were excluded. The sample was divided into survivors and deceased patients so as to identify risk factors for mortality using univariate and multivariate analyses, taking their clinical characteristics as predictive variable, and death at the ICU as the outcome variable. Results. Out of 1496 patients, 66 developed acute kidney injury (4.4%). The cause was secondary in 72.8% of cases, and due to primary kidney disease in 27.2% of cases. Mortality rate was 44% (29 patients). The univariate analysis showed that the presence of anuria (p= 0.0003; OR: 7.01; 95% CI: 2.3-21.35) and the need of dialysis (p= 0.0009; OR: 6.35; 95% CI: 2.03-9.88) were signifcantly higher in deceased patients. The multiple regression analysis identifed that the need of dialysis (p = 0.0002; OR: 5.94; 95% CI: 1.85-19.04) was an independent risk factor for mortality. Conclusions. The incidence of acute kidney injury in critically ill children was 4.4%, and the need of dialysis was an independent predictor of mortality.(AU)

Introducción. El daño renal agudo es una complicación frecuente que se asocia a un aumento de la mortalidad en los niños que requieren cuidados intensivos. El objetivo de este estudio fue determinar su incidencia e identifcar los factores de riesgo de mortalidad en los pacientes críticos internados en nuestra institución. Pacientes y métodos. Estudio prospectivo y observacional realizado en la unidad de terapia intensiva (UTI) del Hospital Pedro de Elizalde entre 2005 y 2009. Se incluyeron todos los pacientes con daño renal agudo, exceptuando a aquellos con insufciencia renal crónica, daño agudo prerrenal, síndrome hepatorrenal, recién nacidos y posquirúrgicos cardiovasculares. La muestra se dividió en sobrevivientes y fallecidos para identifcar los factores de riesgo de mortalidad mediante un análisis univariado y multivariado, considerando como variable de predicción sus características clínicas, y de resultado, la muerte en la UTI. Resultados. De 1496 pacientes, 66 presentaron daño renal agudo (4,4%). En el 72,8% de los casos fue de causa secundaria y en el 27,2%, por enfermedad renal primaria. La mortalidad fue de 44% (29 pacientes). En el análisis univariado la presencia de anuria (p= 0,0003; OR 7,01; IC 95% 2,3 a 21,35) y la necesidad de diálisis (p= 0,0009; OR 6,35; IC 95% 2,03 a 9,88) fueron signifcativamente mayores en los fallecidos. Por regresión múltiple se identifcó la necesidad de diálisis (p= 0,0002; OR 5,94; IC 95% 1,85 a 19,04) como factor de riesgo independiente de mortalidad. Conclusiones. La incidencia de daño renal agudo en los niños críticos fue de 4,4% y el requerimiento de diálisis fue un predictor independiente de mortalidad.(AU)

Acute kidney injury in critically ill children: incidence and risk factors for mortality / Daño renal agudo en niños críticos: incidencia y factores de riesgo de mortalidad

Introduction. Acute kidney injury is a common complication associated with an increase in mortality in children who require intensive care. The objective of this study was to determine the incidence of acute kidney injury and identify risk factors for mortality in critically ill patients hospitalized in our facility. Patients and Methods. This was a prospective and observational study conducted at the Intensive Care Unit (ICU) of Hospital Pedro de Elizalde between 2005 and 2009. All patients with acute kidney injury were included, and those with chronic renal failure, prerenal acute kidney injury, hepatorenal syndrome, newborn infants, and postoperative cardiovascular surgery patients were excluded. The sample was divided into survivors and deceased patients so as to identify risk factors for mortality using univariate and multivariate analyses, taking their clinical characteristics as predictive variable, and death at the ICU as the outcome variable. Results. Out of 1496 patients, 66 developed acute kidney injury (4.4%). The cause was secondary in 72.8% of cases, and due to primary kidney disease in 27.2% of cases. Mortality rate was 44% (29 patients). The univariate analysis showed that the presence of anuria (p= 0.0003; OR: 7.01; 95% CI: 2.3-21.35) and the need of dialysis (p= 0.0009; OR: 6.35; 95% CI: 2.03-9.88) were signifcantly higher in deceased patients. The multiple regression analysis identifed that the need of dialysis (p = 0.0002; OR: 5.94; 95% CI: 1.85-19.04) was an independent risk factor for mortality. Conclusions. The incidence of acute kidney injury in critically ill children was 4.4%, and the need of dialysis was an independent predictor of mortality.

Introducción. El daño renal agudo es una complicación frecuente que se asocia a un aumento de la mortalidad en los niños que requieren cuidados intensivos. El objetivo de este estudio fue determinar su incidencia e identifcar los factores de riesgo de mortalidad en los pacientes críticos internados en nuestra institución. Pacientes y métodos. Estudio prospectivo y observacional realizado en la unidad de terapia intensiva (UTI) del Hospital Pedro de Elizalde entre 2005 y 2009. Se incluyeron todos los pacientes con daño renal agudo, exceptuando a aquellos con insufciencia renal crónica, daño agudo prerrenal, síndrome hepatorrenal, recién nacidos y posquirúrgicos cardiovasculares. La muestra se dividió en sobrevivientes y fallecidos para identifcar los factores de riesgo de mortalidad mediante un análisis univariado y multivariado, considerando como variable de predicción sus características clínicas, y de resultado, la muerte en la UTI. Resultados. De 1496 pacientes, 66 presentaron daño renal agudo (4,4%). En el 72,8% de los casos fue de causa secundaria y en el 27,2%, por enfermedad renal primaria. La mortalidad fue de 44% (29 pacientes). En el análisis univariado la presencia de anuria (p= 0,0003; OR 7,01; IC 95% 2,3 a 21,35) y la necesidad de diálisis (p= 0,0009; OR 6,35; IC 95% 2,03 a 9,88) fueron signifcativamente mayores en los fallecidos. Por regresión múltiple se identifcó la necesidad de diálisis (p= 0,0002; OR 5,94; IC 95% 1,85 a 19,04) como factor de riesgo independiente de mortalidad. Conclusiones. La incidencia de daño renal agudo en los niños críticos fue de 4,4% y el requerimiento de diálisis fue un predictor independiente de mortalidad.

Impact of platelet transfusions in children with post-diarrheal hemolytic uremic syndrome.

BACKGROUND: Platelet transfusions should be avoided in children with post-diarrheal hemolytic uremic syndrome (D + HUS) because they might increase microthrombi formation, thereby aggravating the disease. As this possibility has not yet been explored, we investigated whether platelet transfusion in patients with D + HUS would lead to a worse disease course compared to that in patients who did not receive platelet transfusion. METHODS: This was a case-control study in which data from D + HUS children who received platelet transfusions (cases, n = 23) and those who did not (controls, n = 54) were retrospectively reviewed and compared. RESULTS: Both patient groups were similar in age (p = 0.3), gender (p = 0.53), weight (p = 0.86), height (p = 0.45), prior use of non-steroidal anti-inflammatory drugs (p = 0.59) or antibiotics (p = 0.45) and presence of dehydration at admission (p = 0.79). The two groups also did not differ in initial leukocyte count (p = 0.98), hematocrit (p = 0.44) and sodium (p = 0.11) and alanine aminotransferase levels (p = 0.11). During hospitalization, dialysis duration (p = 0.08), number of erythrocyte transfusions (p = 0.2), serum creatinine peak (p = 0.22), presence of severe bowel (p = 0.43) or neurologic (p = 0.97) injury, arterial hypertension (p = 0.71), need for intensive care (p = 0.33) and death (p = 1.00) were also comparable. CONCLUSION: Our findings suggest that platelet transfusion does not aggravate the course of the disease. Conversely, no hemorrhagic complications were observed in the group of patients who did not receive a platelet transfusion. Until these observations are confirmed by further studies, the benefits and risk of platelet transfusion should be thoughtfully balanced on an individual case basis.