ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Dermatitis, Contact/diagnosis , Dermatitis, Contact/therapy , Manganese/adverse effects , Manganese Compounds/adverse effects , Dental Materials/adverse effects , Eczema/diagnosis , Eczema/therapy , Orthodontic Wires/adverse effects , Orthodontics/methodsABSTRACT
UNLABELLED: Narrowband UV-B is a safe and efficacious option for the treatment of adult psoriasis. However, the use of this therapy has been limited in children due to its long-term carcinogenic potential. It has proven to be an adequate alternative in patients whose condition is refractory to topical treatment. AIMS: To evaluate the efficacy and short-term safety of narrowband UV-B in the treatment of paediatric psoriasis, and to compare our results with those obtained in other studies on paediatric psoriasis. MATERIALS AND METHODS: Over a period of 2 years and 4 months, we administered narrowband UV-B to 20 children diagnosed with psoriasis that was refractory to topical therapy. The therapeutic response was measured using the Psoriasis Area and Severity Index (PASI). RESULTS: Between August 2005 and December 2007, 20 children received narrowband UV-B. Their median age was 13 years (range, 5-17 years), and the median initial PASI score was 8.25 (2.7-22.2). A median of 28 (10-59) sessions was required to achieve clearance, reaching almost complete or total remission (median final PASI) in all but two patients. Six patients required a new therapeutic course because of relapse, and the mean duration of remission was 8 months (4-18). No patients experienced severe adverse events during therapy, and only one discontinued treatment, for unrelated reasons. DISCUSSION AND CONCLUSION: Narrowband UV-B for the treatment of paediatric psoriasis has received little attention in the literature. This treatment has been limited in children because of its potential long-term carcinogenic effects, and most information has been extrapolated from adults. Nevertheless, narrowband UV-B phototherapy is an effective and well-tolerated therapeutic alternative in paediatric patients with severe psoriasis.
Subject(s)
Psoriasis/radiotherapy , Severity of Illness Index , Skin/radiation effects , Ultraviolet Therapy/methods , Adolescent , Child , Child, Preschool , Female , Humans , Longitudinal Studies , Male , Recurrence , Remission Induction , Retrospective Studies , Skin Pigmentation , Treatment Outcome , Ultraviolet Therapy/adverse effectsSubject(s)
Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Manganese/adverse effects , Orthodontic Appliances/adverse effects , Prosthodontics , Burning Mouth Syndrome/etiology , Chlorides , Female , Humans , Manganese Compounds , Patch Tests , Pruritus/etiology , Young AdultABSTRACT
No disponible
No disponible
Subject(s)
Humans , Female , Adult , Orofaciodigital Syndromes/diagnosis , Maxillofacial Abnormalities/etiology , Fingers/abnormalitiesSubject(s)
Antineoplastic Agents/toxicity , Benzenesulfonates/toxicity , Drug Eruptions/etiology , Foot Dermatoses/chemically induced , Hand Dermatoses/chemically induced , Pyridines/toxicity , Drug Eruptions/pathology , Foot Dermatoses/pathology , Hand Dermatoses/pathology , Humans , Male , Middle Aged , Niacinamide/analogs & derivatives , Phenylurea Compounds , SorafenibABSTRACT
No disponible
No disponible
Subject(s)
Humans , Male , Middle Aged , Protein-Tyrosine Kinases/antagonists & inhibitors , Drug Eruptions/diagnosis , Carcinoma, Hepatocellular/complications , Hepatitis C, Chronic/complications , Adrenal Cortex Hormones/administration & dosage , Administration, TopicalABSTRACT
La morfea localizada es una afección poco frecuente en la infancia. Su relevancia se debe a que ciertas formas pueden llevar a una esclerodermia generalizada, y a que la localización de las placas de morfea puede alterar la funcionalidad de la estructura anatómica donde asientan(AU)
Localised morphea is a condition that rarely occurs during childhood. Its relevance is due to the fact that certain forms may lead to generalised scleroderma, and to the fact that the location of the plaques of morphea may alter the functionality of the anatomical structure on which they occur. We present a case of localised morphea with periurethral and acral involvement(AU)
Subject(s)
Humans , Male , Child , Scleroderma, Localized/complications , Scleroderma, Localized/diagnosis , Scleroderma, Localized/therapy , Lichen Sclerosus et Atrophicus/complications , Lichen Sclerosus et Atrophicus/diagnosis , Balanitis/complications , Adrenal Cortex Hormones/therapeutic use , Scleroderma, Localized/epidemiology , Balanitis/drug therapy , Urethra/pathologyABSTRACT
El granuloma piógeno es una lesión vascular de piel y mucosas relativamente frecuente cuya etiopatogenia es desconocida. l término «granuloma piógenoll es erróneo, ya que no existen evidencias de su naturaleza infecciosa e histológicamente no se observan granulomas. Su incidencia es similar en los dos sexos y habitualmente aparece en niños y jóvenes adultos. Clínicamente se caracteriza por la presencia de una pápula o nódulo de crecimiento rápido, de apariencia angiomatosa, que sangra y se ulcera con facilidad. El afeitado o raspado de la lesión seguido de la electrocoagulación de la base con anestesia local suele ser una buena opción terapéutica
Pyogenicg ranuloma is a relatively common enign vascular lesion of the skin and mucosa, the exact cause of which is unknown. This misnamed entity is neither infectious nor granulomatous. The lesion usually occurs in children and young adults without sex predilection. Clinically, it appears as a solitary red papule or nodule that is prone to bleeding and ulceration. It typically evolves rapidly over a period of a few weeks. Shave excision or curettage with electrodesiccation of the base under local anesthesia is usually a good therapeutic option
Subject(s)
Male , Child , Humans , Granuloma, Pyogenic/diagnosis , Granuloma, Pyogenic/therapy , Vascular Neoplasms/diagnosisABSTRACT
La esclerosis tuberosa es una enfermedad neurocutánea de herencia autosómica dominante y expresividad variable que afecta a la diferenciación y proliferación celular con la formación de hamartomas en distintos órganos. A pesar de que se han identificado dos genes, TSC1 y TSC2, situados en los cromosomas 9:9q34 y 16:16p13, respectivamente, el diagnóstico de la enfermedad es clínico ya que los tests genéticos tienen un porcentaje elevado de falsos negativos(15%). Las manifestaciones clínicas varían enormemente incluso entre familiares. La presencia de lesiones cutáneas características es de gran utilidad para orientar el diagnóstico. El enfoque debe ser multidisciplinario ya que puede existir afectación renal, pulmonar, cardiacao del sistema nervioso central con importante morbilidad. Es importante prestar atención a dichas complicacione sistémicas para minimizar las secuelas de la esclerosis tuberosa
Tuberous sclerosis is an autosomal dominant disorder involving tumor-like growth or hamartomas in multiple organ systems. Although two genes, TSC1 and TSC2, localized on chromosomes 9q34.3 and 16p13.3, have been identified, the disease requires clinical diagnosis because genetic tests are associated with a high false-negative rate (15%). The clinical manifestations of tuberous sclerosis very greatly, even among members of the same family. The recognition of the characteristic cutaneous lesions may contribute to its early diagnosis. The approach should be multidisciplinary, as the involvement of the kidneys, lungs, heart and central nervous system may result in severe morbidity. Close attention to these manifestations is necessary to ensure the appropriate treatment of the sequelae of tuberous sclerosis
