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Talanta ; 164: 183-188, 2017 Mar 01.
Article in English | MEDLINE | ID: mdl-28107915

ABSTRACT

This paper describes an environmentally friendly procedure for the determination of losartan potassium (Los-K) in pharmaceuticals. The photometric method was based on the light scattering effect due to particles suspension, which were formed by the reaction of Los-K with Cu (II) ions. The method was automated employing a multicommuted flow analysis approach, implemented using solenoid mini-pumps for fluid propelling and a homemade LED based photometer. Under the optimized experimental conditions, the procedure showed a linear relationship in the concentration range of 23.2-417.6mgL-1 (r=0.9997, n=6), a relative standard deviation of 1.61% (n=10), a limit of detection (3.3*σ) estimated to be 12.1mgL-1, and a sampling rate of 140 determinations per hour. Each determination consumed 12µg of copper (II) acetate and generated 0.54mL of waste.


Subject(s)
Light , Losartan/analysis , Pharmaceutical Preparations/chemistry , Photometry/methods , Scattering, Radiation , Copper/chemistry , Losartan/chemistry
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