ABSTRACT
PURPOSE: Improving of otitis media with effusion (OME) with rhinosinusitis (RS) and adenoiditis treatment effectiveness. MATERIALS AND METHODS: The study included 112 patients 12-18 y.o. with otitis media with effusion, who were divided into 2 groups depending on the treatment scheme. The Group I (the main group) patients treatment included Traumeel S and Euphorbium compositum Nasentropfen S in addition to the standard treatment, and the Group II (comparison), children were prescribed standard therapy. Patients of both groups were divided into 3 subgroups depending on the upper respiratory tract inflammation symptoms: A - patients with adenoiditis; B - with rhinosinusitis and C - combination of adenoiditis and rhinosinusitis. The comparison group (groups IIB and IIC) treatment scheme (children with rhinosinusitis) included topical corticosteroids and the main group patients didn't receive corticosteroids. All patients went through complaints and anamnesis collection, routine otorhinolaryngological and instrumental examination before and after treatment. RESULTS: Analysis of treatment results demonstrated high efficacy of multicomponent drugs with low doses of active ingredients in the therapy of patients with OME, regardless of comorbid pathology. Significantly better results were obtained in the patients treated with bioregulatory drugs when comparing the outcomes of OME therapy in combination with adenoiditis (groups IA and IIA). Comparable efficacy results were obtained in the treatment group of patients with OME associated with RS (in groups IB and IIB as well as in groups IC and IIC), where GCS was received in the comparison group. The high efficacy and safety of bioregulatory drugs makes the use of these agents a promising treatment for patients with OME, RS and adenoiditis.
Subject(s)
Nasopharyngitis , Otitis Media with Effusion , Otitis Media , Sinusitis , Child , Humans , Otitis Media with Effusion/complications , Otitis Media with Effusion/diagnosis , Otitis Media with Effusion/drug therapy , Sinusitis/complications , Sinusitis/diagnosis , Sinusitis/drug therapy , Nasopharyngitis/complications , Nasopharyngitis/diagnosis , Glucocorticoids , Adrenal Cortex Hormones/therapeutic use , Otitis Media/complicationsABSTRACT
OBJECTIVE: to study post-accident levels of illnesses system diseases of residents from radioactively contaminatedareas aged 0-60 years on the date of the Chornobyl accident, and to analyze the effect of chronic low-dose ionizingradiation. MATERIALS AND METHODS: Epidemiological research and analysis of morbidity of circulatory system diseases of resi-dents of radioactively contaminated areas (RCA) has been carried out. The individuals who were studied includedRCA residents aged 0-60 (98, 902 persons) on the date of the Chornobyl accident. The data of the victims' annualmedical examinations during 1988-2016 were received from the State Register of Ukraine (SRU). Detection of thepossible dependence of the development of circulatory system diseases on the effects of ionizing radiation was car-ried out in the range of individual total effective doses ranging from 13-40 mSv and more as accumulated over26 years after the Chornobyl accident. The control group consisted of individuals with a radiation dose of <13 mSv.The statistical analysis of data was performed using the Microsoft Office Excel 2013 software packages. RESULTS: For the entire period of the study, 20,552 cases of circulatory system diseases were detected for the firsttime (ID at 103 person-years is 15.66 ± 0.11), incl. men, respectively, 7,211 cases (12.32 ± 0.14), women - 13,341cases (18.35 ± 0.16). It has been determined that among the circulatory system diseases of RZT residents there isthe most express display of ischemic heart disease, a disease characterized by high blood pressure, including otherheart diseases. The dependence of the levels of morbidity on the diseases of the circulatory system on the sex ofvictims was established. A connection has been established between the development of certain circulatory systemdiseases and the amounts of individual total effective doses of ionizing radiation accumulated over the period of1986-2012. Individual total effective doses of ionizing radiation in men and women in the range of doses of13-40 mSv or more. CONCLUSIONS: On the basis of cohort epidemiological studies, there was studied the dynamics of levels of circulatory system diseases among the RCT residents aged 0-60 years on the date of the Chornobyl accident during the observation period of 1988-2016. The overstated levels of cardiovascular and cerebrovascular diseases were established in the first twelve post-accident years, especially in the first six years. The highest morbidity rates for circulatory system diseases were identified in women over men. The development of certain circulatory system diseases, both in men and women, in a certain period is associated with the amount of dose of ionizing radiation from radionuclides 134Сs, 137Сs.
Subject(s)
Cerebrovascular Disorders/epidemiology , Chernobyl Nuclear Accident , Radiation, Ionizing , Registries , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Case-Control Studies , Cerebrovascular Disorders/complications , Cerebrovascular Disorders/pathology , Child , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Longitudinal Studies , Male , Middle Aged , Radiation Dosage , Radiometry/methods , Sex Factors , Ukraine/epidemiologyABSTRACT
In this paper, a clinical case of combination of chronic myeloid leukemia and T-lymphoblastic lymphoma is present-ed, which is currently a rather rare finding for a clinician. The diagnosis of T-lymphoblastic lymphoma is establishedafter 2 years from the verification of chronic myeloid leukemia. The course of diseases and approaches to treatmentare described.The pathogenetic relationship between myeloid and lymphoid diseases remains unclear and is likely to be the resultof several factors - radiation, chemical and, consequently, genetic disorders.
Subject(s)
Antineoplastic Agents/therapeutic use , Chernobyl Nuclear Accident , Environmental Exposure/adverse effects , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Lymphoma, T-Cell/pathology , Radiation Exposure/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Female , Humans , Hydroxyurea/administration & dosage , Hydroxyurea/adverse effects , Imatinib Mesylate/therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/etiology , Lymphoma, T-Cell/complications , Lymphoma, T-Cell/drug therapy , Lymphoma, T-Cell/etiology , Middle Aged , Prednisone/therapeutic use , Radiation, Ionizing , Treatment Outcome , Ukraine , Vincristine/therapeutic useABSTRACT
A clinical case of the rituximab («Rituksim¼, «Mabthera¼) use to treat a man affected by the Chornobyl NPP acci dent with malignant resistant form of myasthenia gravis in conjunction with chronic mixed infection by Toxoplasma, Epstein Barr virus, Cytomegalovirus and Herpes simplex virus is described. In the dynamics of two year's observa tion the clinical efficacy of monoclonal antibodies was shown as the main symptoms stabilization and reducing doses of glucocorticoid and anticholinergic therapy. The positive effect was marked in the nearest and remote peri ods. Taking to account the efficacy, safety and good tolerability of rituximab, it is advisable to recommend treat ment for people exposed to ionizing radiation and developing myasthenia associated with chronic mixed infection by Toxoplasma, Epstein Barr, Cytomegalovirus and Herpes simplex virus.
Subject(s)
Chernobyl Nuclear Accident , Myasthenia Gravis/drug therapy , Radiation Exposure/adverse effects , Rituximab/therapeutic use , Virus Diseases/drug therapy , Antiviral Agents/therapeutic use , Cholinergic Antagonists/therapeutic use , Cytomegalovirus/drug effects , Cytomegalovirus/growth & development , Drug Dosage Calculations , Drug Therapy, Combination , Glucocorticoids/therapeutic use , Herpesvirus 4, Human/drug effects , Herpesvirus 4, Human/growth & development , Humans , Male , Middle Aged , Myasthenia Gravis/etiology , Myasthenia Gravis/pathology , Radiation Dosage , Simplexvirus/drug effects , Simplexvirus/growth & development , Survivors , Treatment Outcome , Virus Diseases/etiology , Virus Diseases/pathologyABSTRACT
BACKGROUND: After stimulation due to injury, cell division cycle protein 42 (Cdc42) restores and enhances barrier functions by strengthening intercellular adherens junctions; however, its influence on cell proliferation after injury remains unknown. OBJECTIVE: In this study, we sought to investigate the effect of stimulation using small doses of lipopolysaccharide (LPS) on the proliferation of pulmonary microvascular endothelial cells (PMVECs). METHODS: We stimulated PMVECs with different doses of LPS and evaluated the effects on cell proliferation. We also constructed a primary gene-knockout cell line lacking Cdc42 to verify the role of Cdc42 in regulating the proliferation of PMVECs that were stimulated using LPS and to explore related signaling pathways. RESULTS: Stimulating PMVECs with small doses of LPS increased proliferation. Cdc42 is involved in regulating this process, which was mediated by the extracellular regulated protein kinase (ERK) pathway. CONCLUSIONS: Cdc42 plays a role in regulating the proliferation of PMVECs stimulated with small doses of LPS, and this regulation involves the ERK pathway.
Subject(s)
Endothelial Cells/cytology , Lung/cytology , MAP Kinase Signaling System , Microcirculation , cdc42 GTP-Binding Protein/metabolism , Animals , Cell Proliferation , Endothelium, Vascular/cytology , Extracellular Signal-Regulated MAP Kinases/metabolism , Humans , Lipopolysaccharides , Lung/blood supply , Mice , Mice, Inbred C57BL , Mice, Knockout , Microvessels/cytology , Signal TransductionABSTRACT
Objective To investigate the effect of the small dose dopamine on the surgical rate, curative effect and adverse reactions of the neonatal necrotic enteritis. Methods From January 2013 to January 2017 in our hospital for treatment of 60 cases of neonatal necrotizing enterocolitis were as the research object, and to give a randomized, control group 30 cases, give simple phentolamine static drop treatment; Intervention group, 30 cases in the control group on the basis of small dose dopamine was given to two groups of children with fasting time, length of hospital stay, operation rate, efficacy and adverse reactions happen to comprehensive evaluation. Results The average fasting time and hospital length of the intervention group were significantly better than the control group (P< 0.05), which was statistically significant. Intervention group with operation rate and total effective rate were 3.3％, 93.3％, the control rate of surgery, treatment in children with total effective rate of 16.7％, 70.0％ respectively, there are statistically significant difference (P< 0.05); There were only two cases of adverse reaction in the intervention group, 6.7％, and the difference of 23.3％ in the control group was statistically significant (P< 0.05). Conclusion On the basis of phentolamine treatment of neonatal necrotizing enterocolitis with small dose of dopamine was given to shortening the time of fasting and hospitalization time, decrease the rate of transit operation, and less adverse reaction, curative effect is distinct, worthy of clinical popularization and application.
ABSTRACT
Objective:To study the value of small dose sufentanil in anesthesia in caesarean section for prevention of chill and dragging pain. Methods:A total of 84 cases of caesarean section maternal in our hospital were choosen for study as the object. And they were randomly divided into two groups, with 42 cases in each group. The experimental group implements the sufentanil 5μg, control group was given 0.5%ropivacaine. Chills,dragging pain and other adverse reactions were compared. Results:The incidence rate of level 0 chills in experimental group was 80.95%,and it's higher than that 50.00%of control group (P<0.01) . Maternal pull pain incidence rate of experiment group was 14.92%, while the control group was 73.81%(P<0.01) . The other adverse reaction rate in experimental group was lower than that in the control group (P<0.01) . Conclusion:Small doses sufentanil anesthesia for cesarean section can significantly reduce the occurrence of adverse reactions such as pain and chills,safe and effective,it's worthy of clinical popularization and application.
ABSTRACT
La Homeopatía se fundó sobre un método que es, al mismo tiempo, experimental y empírico. La Homeopatía es parcialmente experimental debido a que su semiología nació con la experimentación sobre el hombre sano, efectuada según el método hahnemanniano; asimismo, es parcialmente empírica porque se basa en el trabajo de observación de los médicos homeópatas y en la adquisición de la experiencia práctica, la cual ha sido transmitida a alumnos deseosos de utilizar este método terapéutico. La investigación en Homeopatía se ha desarrollado progresivamente, tratando de integrar las aportaciones de estos dos métodos: experimental y empírico. De hecho, los esfuerzos realizados por situar a la Homeopatía dentro de una metodología rigurosa se remontan al inicio mismo de esta disciplina, inscrita desde su origen por Hahnemann dentro de la línea científica y médica original...
Homeopathy is in part experimental because the semiology was born with the experimentation on the healthy man, which was performed according to Hahnemann´s method; it is also partly empirical because much work is based on the observation of homeopaths and the acquisition of practical experience, which has been transmitted to students eager to use this therapeutic method. Research in Homeopathy has been gradually developed, trying to integrate the contributions of these two methods: experimental and empirical. In fact, efforts have been made to place homeopathy within a rigorous methodology dating back to the beginning of the discipline itself, from its origin registered by Hahnemann within the original scientific and medical field...
Subject(s)
Humans , High Potencies , Homeopathic Philosophy , Homeopathic Remedy , Simillimum Potency , Small DosesABSTRACT
La Homeopatía se fundó sobre un método que es, al mismo tiempo, experimental y empírico. La Homeopatía es parcialmente experimental debido a que su semiología nació con la experimentación sobre el hombre sano, efectuada según el método hahnemanniano; asimismo, es parcialmente empírica porque se basa en el trabajo de observación de los médicos homeópatas y en la adquisición de la experiencia práctica, la cual ha sido transmitida a alumnos deseosos de utilizar este método terapéutico. La investigación en Homeopatía se ha desarrollado progresivamente, tratando de integrar las aportaciones de estos dos métodos: experimental y empírico. De hecho, los esfuerzos realizados por situar a la Homeopatía dentro de una metodología rigurosa se remontan al inicio mismo de esta disciplina, inscrita desde su origen por Hahnemann dentro de la línea científica y médica original. (AU)
Homeopathy is in part experimental because the semiology was born with the experimentation on the healthy man, which was performed according to Hahnemann´s method; it is also partly empirical because much work is based on the observation of homeopaths and the acquisition of practical experience, which has been transmitted to students eager to use this therapeutic method. Research in Homeopathy has been gradually developed, trying to integrate the contributions of these two methods: experimental and empirical. In fact, efforts have been made to place homeopathy within a rigorous methodology dating back to the beginning of the discipline itself, from its origin registered by Hahnemann within the original scientific and medical field. (AU)
Subject(s)
Fundamentals of Homeopathy , Homeopathic Philosophy , Homeopathic Remedy , Small Doses , High Potencies , Simillimum PotencyABSTRACT
Objective To discuss the application value of small doses penehyclidine hydrochloride in painless colonoscopy examination. Methods From July 2012 to January 2013, 90 patients who planed to have painless colonoscopy were randomly divided into 3 groups with each group 30 cases. Before anesthesia, giving small doses of penehyclidine hydrochloride to small-dose group, giving conventional dose of penehyclidine hydrochloride to routine-dose group, and giving atropine intravenous administration to atropine group. Observe the smoothly de-gree, and check the heart rate, mean arterial pressure and postoperative adverse reactions of three groups. Results There was no obvious difference among the three groups in trems of smooth degree and oxyhemoglobin saturation. In small-dose group, heart rate and mean arterial pressure before and after the examination were better than that of routine-dose group and atropine group, and there were obviously lower inci-dence of postoperative adverse reaction compared with the routine-dose group and atropine group. Conclusion Giving small-dose of penehy-clidine hydrochloride before anesthesia of painless colonoscopy examination can significantly improve the effect of examination, and it can re-duce the incidence of postoperative adverse reactions.
ABSTRACT
In 1849, Charles Darwin was so ill that he was unable to work one out of every 3 days, and after having various troubling symptoms for 2-12 years, he wrote to a friend that he was 'going the way of all flesh'. He sought treatment from Dr James Manby Gully, a medical doctor who used water cure and homeopathic medicines. Despite being highly skeptical of these treatments, he experienced a dramatic improvement in his health, though some of his digestive and skin symptoms returned various times in his life. He grew to appreciate water cure, but remained skeptical of homeopathy, even though his own experiments on insectivore plants using what can be described as homeopathic doses of ammonia salts surprised and shocked him with their significant biological effect. Darwin even expressed concern that he should publish these results. Two of Darwin's sons were as incredulous as he was, but their observations confirmed the results of his experiments. Darwin was also known to have read a book on evolution written by a homeopathic physician that Darwin described as similar to his own but 'goes much deeper.'
