1.
Chinese Journal of Laboratory Medicine
; (12): 839-843, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-667364
ABSTRACT
Skeletal metabolic disorder refers to multi-factors caused by bone tissue calcium, phosphorus and other minerals,osteoblasts and(or)osteoclast dysfunction.The FGF23-Klotho axis plays an important role in the bone-kidney-parathyroid axis and is involved in the regulation of bone mineral metabolism.At the same time, FGF23-Klotho axis affects the synthesis and secretion of vitamin D and parathyroid hormone.With the deepening of research,the FGF23-Klotho axis is promising to be the target of diagnosis and treatment of bone metabolic disorders.