Does study subject diversity influence cardiology research site performance?: Insights from 2 U.S. National Coronary Stent Registries.

BACKGROUND: Minorities and women are underrepresented in cardiovascular research. Whether their higher enrollment can be predicted or influences research site performance is unclear. METHODS: We evaluated 104 sites that enrolled 4,184 patients in the U.S. Platinum Diversity (PD) and Promus Element Plus (PE Plus) studies (2012 to 2016). Research sites were ranked from lowest to highest minority and female enrollment, respectively. United States Census Bureau division and core-based statistical area (CBSA) populations were determined for each site and the following study performance metrics compared across quartiles of minority and female enrollment, respectively: (1) study subject enrollment rate (SER), (2) time to first patient enrolled, (3) rate of follow-up visits not done, (4) rate of follow-up visits out of window, and (5) protocol deviation rate (PDR). Multivariable regression was used to predict SER and PDR. RESULTS: Minority enrollment varied by region (P = .025) and population (P = .024) with highest recruitment noted in the Pacific, West South Central, South Atlantic, Mid-Atlantic and East North Central divisions. Female enrollment bore no relationship to region (P = .67) or population (P = .40). Median SER was similar in sites withi the highest vs lowest quartile of minority enrollment (SER of 4 vs 5 patients per month, respectively, P =0.78) and highest vs. lowest female enrollment (SER of 4 vs 4, respectively, P = .21). Median PDR was lower in sites within the highest vs lowest minority enrollment (0.23 vs 0.50 PDs per patient per month, respectively, P = .01) and highest vs. lowest female enrollment (0.28 vs. 0.37 PDs per patient per month, respectively, P = .04). However, this relationship did not persist after multivariable adjustment. All other site performance metrics were comparable across quartiles of minority and female enrollment. CONCLUSIONS: Minority, but not female enrollment, correlated with research site geographic region and surrounding population. High enrollment of minorities and women did not influence study performance metrics. These findings help inform future strategies aimed at increasing clinical trial diversity. TRIAL REGISTRATION: The PD and PE Plus studies are registered at www.clinicaltrials.gov under identifiers NCT02240810 and NCT01589978, respectively. KEY POINTS: Question: Does the enrollment of more Blacks, Hispanics and women in US cardiovascular research studies influence the overall rate of study subject enrollment and/or other key study site performance metrics and can diverse enrollment be predicted? FINDINGS: In this pooled analysis of 104 sites that enrolled 4,184 patients in the Platinum Diversity and Promus Element Plus Post-Approval Studies, we found that the enrollment of higher proportions of underrepresented minorities and women was univariately associated with lower protocol deviation rates while having no effect on other site performance metrics. A site's geographic location and surrounding population predicted minority, but not female enrollment. Meaning: These findings suggest that cardiovascular research subject diversity may be predicted from site characteristics and enhanced without compromising key study performance metrics. These insights help inform future strategies aimed at improving clinical trial diversity.

The Contested Whiteness of Arab Identity in the United States: Implications for Health Disparities Research.

In response to the Institute on Minority Health and Health Disparities' (NIMHD) new health disparities research framework, we call on the National Institutes of Health (NIH) to acknowledge Arabs in the United States as a health disparity population. Arab classification as White leads to their cultural invisibility and perpetuates a cycle of undocumented health disparities.We provide examples of how this contested identity reinforces challenges associated with identifying this population and contributes to enactments of structural violence and undocumented health disparities. Decades of research with Arabs in the United States provides consistent evidence that their health does not fit the health profile of White Americans and that Arabs do not benefit from Whiteness and White privilege associated with their White racial categorization. On the contrary, Arabs in the United States experience discrimination and health disparities that require urgent attention; this can be achieved only by identifying the population with a racial category other than White.We conclude with recommendations to NIH and NIMHD to revise their definition of health disparity populations to include Arabs in the United States.

"I thought you were Japanese": Ethnic miscategorization and identity assertion.

Across 2 studies we examined how ethnic minorities respond to ethnic miscategorization. Using a 21-day experience sampling procedure (Study 1), we found that ethnic minorities exhibited greater ethnic identity assertion when they had reported being ethnically miscategorized the previous day. Similarly, we found that ethnic minorities who were ethnically miscategorized (vs. not) by a White partner in the laboratory exhibited greater ethnic identity assertion and expressed greater dislike of their partner (Study 2). In both studies, these effects were stronger for individuals whose ethnic identity was central to their self-concept. The implications of these findings for ethnic identity development and intergroup relations are discussed. (PsycINFO Database Record

Classification of Canadian immigrants into visible minority groups using country of birth and mother tongue.

BACKGROUND: The Permanent Resident Database of Citizenship and Immigration Canada (CIC) contains sociodemographic information on immigrants but lacks ethnic group classifications. To enhance its usability for ethnicityrelated research, we categorized immigrants in the CIC database into one of Canada's official visible minority groups or a white category using their country of birth and mother tongue. METHODS: Using public data sources, we classified each of 267 country names and 245 mother tongues in the CIC data into 1 of 10 visible minority groups (South Asian, Chinese, black, Latin American, Filipino, West Asian, Arab, Southeast Asian, Korean, and Japanese) or a white group. We then used country of birth alone (method A) or country of birth plus mother tongue (method B) to classify 2.5 million people in the CIC database who immigrated to Ontario between 1985 and 2010 and who had a valid encrypted health card number. We validated the ethnic categorizations using linked selfreported ethnicity data for 6499 people who responded to the Canadian Community Health Survey (CCHS). RESULTS: Among immigrants listed in the CIC database, the 4 most frequent visible minority groups as classified by method B were South Asian (n = 582 812), Chinese (n = 400 771), black (n = 254 189), and Latin American (n = 179 118). Methods A and B agreed in 94% of the categorizations (kappa coefficient 0.94, 95% confidence interval [CI] 0.93-0.94). Both methods A and B agreed with self-reported CCHS ethnicity in 86% of all categorizations (for both comparisons, kappa coefficient 0.83, 95% CI 0.82-0.84). Both methods A and B had high sensitivity and specificity for most visible minority groups when validated using self-reported ethnicity from the CCHS (e.g., with method B, sensitivity and specificity were, respectively, 0.85 and 0.97 for South Asians, 0.93 and 0.99 for Chinese, and 0.90 and 0.97 for blacks). INTERPRETATION: The use of country of birth and mother tongue is a validated and practical method for classifying immigrants to Canada into ethnic categories.

Las actitudes de los niños de minorías hacia los miembros de un equipo competitivo: el paradigma de grupo mínimo con niños británicos bengalíes / Ethnic Minority Children's Attitudes Towards Competitive Team Members: A Minimal Group Study with British Bengali Children

Desde su formulación a finales de los años 90, la teoría evolutiva de la identidad social (SIDT; Nesdale, 1999) ha sido apoyada por numerosos estudios sobre el paradigma de grupo mínimo, aunque estos se han realizado principalmente con niños del grupo mayoritario. Este trabajo adapta el paradigma experimental de grupo mínimo de Nesdale et al. (2003) para evaluar las predicciones de la SIDT en una muestra de niños de una minoría étnica. Se asignó a 148 niños británicos- bengalíes de 5-6, 7-8 y 9-10 años a un “equipo de dibujo‟ que poseía habilidades superiores a las de un equipo rival. Los miembros del equipo podían ser del mismo grupo étnico (británicos-bengalíes) o diferente (británicos-blancos). Se pidió a los niños que puntuaran su preferencia por el propio equipo y el rival, el grado en que se sentían semejantes a uno y otro, y si deseaban cambiar de equipo. Se encontró que los niños preferían su equipo en mayor medida que al equipo rival, independientemente de la etnia de sus miembros. Sin embargo, los niños se sentían más iguales a su propio equipo cuando estaba formado por miembros de su grupo étnico que por miembros de distinto grupo étnico. Los resultados se comparan con los obtenidos en estudios previos con niños del grupo mayoritario, y se discuten en relación con la SIDT (AU)

Since its inception in the late 1990s, the social identity development theory (SIDT; Nesdale, 1999) has been supported by various minimal group studies, although such work has invariably been done with ethnic majority group children. The present study adapted Nesdale et al.’s (2003) minimal group experiment to test the predictions from SIDT with a sample of ethnic minority children. One hundred and forty-eight British Bengali children aged 5-6, 7-8 and 9-10 years were allocated to a “drawing team‟ that had superior skills than a rival team. The team members were shown to be of the same (Bengali) or a different (white English) ethnicity. Children rated their liking for, and similarity to, their own team and the rival team, and the extent to which they wanted to change teams. It was found that the children preferred their own team members more than the rival team members, irrespective of the ethnic makeup of the teams. However, the children felt more similar to their own team when it was made up of same-ethnic members compared to when it was made up of different-ethnic members. The findings are discussed in relation to those in previous studies with ethnic majority children and support for SIDT (AU)

Sources of self-categorization as minority for mixed-race individuals: Implications for affirmative action entitlement.

Multiracial individuals are in the unique position of being able to categorize themselves as members of multiple racial groups. Drawing on self-categorization theory, we suggest that similarity to the minority ingroup depends on self-perceptions of physical appearance and connectedness to the minority ingroup. Moreover, we argue that similarity to the ingroup determines self-categorization as minority, which predicts category-based entitlements such as perceived eligibility for minority resources (e.g., affirmative action). Using path analysis, we found support for this model on a convenience sample of 107 mixed-race minority-White participants. The results suggest that affective processes rather than observable characteristics such as prototypical physical appearance better predict self-categorization among mixed-race individuals.

The impact of race on organ donation rates in Southern California.

BACKGROUND: The Organ Donation Breakthrough Collaborative began in 2003 to address and alleviate the shortage of organs available for transplantation. This study investigated the patterns of organ donation by race to determine if the Collaborative had an impact on donation rates among ethnic minorities. STUDY DESIGN: The following data from the Southern California regional organ procurement organization were reviewed between 2004 and 2008: age, race (Caucasian, African-American, Asian, Hispanic, and other), the numbers of eligible referrals for organ donation and actual donors, types of donors, consent rates, conversion rates, organs procured per donor (OPPD), and organs transplanted per donor (OTPD). Logistic regression was used to determine independent predictors of ≥4 OTPD. RESULTS: There were 1,776 actual donors out of 2,760 eligible deaths (conversion rate 64%). Hispanics demonstrated a significantly lower conversion rate than Caucasians (64% vs 77%, p < 0.001), but a considerably higher rate than African Americans (50%) and Asians (51%, p < 0.05 for both). There were no significant changes in conversion rates over time in any race. Age was a negative predictor (odds ratio [OR] 0.95), and trauma mechanism (OR 2.1) and standard criteria donor status (OR 2.5) were positive independent predictors of ≥4 OTPD. Race did not affect OTPD (all groups, p > 0.05). CONCLUSIONS: Conversion rates among all ethnic minorities were significantly lower than the rates observed in Caucasians. However, when controlling for other factors, race was not a significant risk factor for the number of organs transplanted per donor. The Collaborative has not had an identifiable effect on race conversion rates during the 5 years since its implementation. Further intervention is necessary to improve the conversion rate in ethnic minorities in Southern California.

Concepts, terminology and classifications for the "mixed" ethnic or racial group in the United Kingdom.

BACKGROUND: The way to categorize people born of inter-ethnic and racial unions - the "mixed" group - remains unclear and requires new insights, given the increasing size and complexity of the group and its emerging health profile. METHODS: A mixed methods research study focusing on ethnic options of young "mixed race" people (n=326) recruited in colleges and universities investigated respondents' preferences with respect to concepts, terminology and classifications. RESULTS: The overwhelming generic term of choice was mixed race, widely interpreted by respondents to include mixed minority groups. Respondents were able to assign themselves in a valid way to a 12-category extended 2001 England and Wales Census classification for "mixed", which collapses into five main groupings and also maps back to the census categories. Among options tested for census purposes, multi-ticking performed poorly and is not recommended. CONCLUSIONS: A more finely granulated classification for "mixed" is feasible where needed, but this requires more extensive testing before it can be judged preferable to a "tick one or more" option that has been shown to have poor reproducibility in validation surveys.

Venous thromboembolism in African-Americans: a literature-based commentary.

Among the cardiovascular diseases and after ischemic heart disease and stroke, venous thromboembolism (VTE) is the third leading cause of death in the U.S. (3). Although VTE is seen across most ethnic groups in the U.S. as well as throughout the world, the rate varies. In the U.S., American Indians/Alaskan Natives as well as Asians have been reported to have a significantly lower rate of deep vein thrombosis (DVT) and pulmonary embolism (PE) as compared to blacks and whites. In sharp conrast blacks appear to have much higher rates than whites. Although these rate differences are thought in part by some to be attributable to disparities in diagnosis and care as well as genetics, it nevertheless is important to define as well as to understand the true incidence and impact so that both public health and clinical resources can be maximally utilized. The purpose of this commentary is to review the VTE burden in the U.S. with respect to ethnicity in terms of clinical demographics and genetics with particular emphasis on blacks.

Distribution of surnames over the Alto Adige-Südtirol region according to local geographic, historical and linguistic features.

This paper aims at analysing the distribution of surnames over the Alto Adige-Südtirol, which is an Italian alpine sub-region coinciding with the province of Bolzano-Bozen. Two thirds of the Alto Adige-Südtirol inhabitants are German mother-tongue, whereas the remaining one third is Italian mother-tongue. There is also a minority represented by Ladin-speaking people. Analyses were carried out using a similarity index between different populations, resulting from heads of family surnames distribution over the area. The specificity of the most frequent surnames was also studied. Mapping of surnames took place at municipality level. Municipality populations were grouped according to their valley of residence and territorial geologic and morphological features. The results were interpreted also in the light of historical events and the presence of specific languages or dialects. The geographic neighbourhood, the geo-morphological features of the territory and the easy individual mobility are the main elements for the relations among people living in the valleys of Alto Adige-Südtirol. The ancient ethno-historical substratum is detectable in the spread of the specific languages and dialects, nevertheless it does not play a discriminative role in the above mentioned relations. The socio-economic factors have contributed both to root the autochthonous people in certain places and to modify the structure of surnames in some valleys.

A meta-analysis of the hepatitis C virus distribution in diverse racial/ethnic drug injector groups.

Hepatitis C virus (HCV) is mostly transmitted through blood-to-blood contact during injection drug use via shared contaminated syringes/needles or injection paraphernalia. This paper used meta-analytic methods to assess whether HCV prevalence and incidence varied across different racial/ethnic groups of injection drug users (IDUs) sampled internationally. The 29 prevalence and 11 incidence studies identified as part of the HCV Synthesis Project were categorized into subgroups based on similar racial/ethnic comparisons. The effect estimate used was the odds or risk ratio comparing HCV prevalence or incidence rates in racial/ethnic minority groups versus those of majority status. For prevalence studies, the clearest disparity in HCV status was observed in the Canadian and Australian Aboriginal versus White comparison, followed by the US non-White versus White categories. Overall, Hispanic IDUs had greater HCV prevalence, and HCV prevalence in African-Americans was not significantly greater than that of Whites in the US. Aboriginal groups showed higher HCV seroconversion rates when compared to others, and African-Americans had lower seroconversion rates compared to other IDUs in the US. The findings suggest that certain minority groups have elevated HCV rates in comparison to other IDUs, which may be a consequence of stigma, discrimination, different risk behaviors or decreased access to health care, services and preventive education. Future research should seek to explicitly explore and explain racial/ethnic variations in HCV prevalence and incidence, and define the groups more precisely to allow for more accurate detection of possible racial/ethnic differences in HCV rates.

Changes in medical care experiences of racial and ethnic groups in the United States, 1996-2002.

The authors examined changes in medical care experiences of racial/ethnic groups (non-Hispanic white, Asian and Pacific Islander, Hispanic, and non-Hispanic black) between 1996 and 2002, using data from the Household Component of Medical Expenditure Panel Surveys. Proportions and adjusted odds ratios for each group's primary care experience are presented. Comparisons are made between groups at each time period and within groups between the two time periods. Multivariable analyses control for demographic and socioeconomic characteristics, health care needs and source of care, and health insurance. Racial/ethnic minorities experienced worse medical care than non-Hispanic whites, but results differed among groups. Non-Hispanic blacks were no different from non-Hispanic whites and showed a slight improvement over time, except for lower odds of having a usual source of care and worse sociodemographic and health indicators. Hispanics had worse experiences than whites in 5 of 8 indicators in 2002 (vs. 3 in 1996). Asians assessed their experience as worse than that of whites in 6 of 8 indicators in 2002 (vs. 3 in 1996), yet had higher self-rated health and education than non-Hispanic whites. Disparities in medical care experience have increased for some groups, and efforts must be made to reduce financial and nonfinancial barriers to care for racial/ethnic minority populations.

Racial disparities in Medicaid enrollment and prenatal care initiation among pregnant teens in Florida: comparisons between 1995 and 2001.

BACKGROUND: Teens and racial and ethnic minority women are less likely to initiate prenatal care (PNC) in the first trimester of pregnancy than their counterparts. OBJECTIVE: This study examines the impact of Medicaid program changes in the late 1990s on the timing of Medicaid enrollment and PNC initiation among pregnant teens by race and ethnicity. RESEARCH DESIGN: Using Medicaid enrollment and claims data and a difference-in-differences method, we examine how the patterns of prepregnancy Medicaid enrollment, PNC initiation, and racial and ethnic disparities in PNC changed over time after controlling for person- and county-level characteristics. SUBJECTS: We included 14,089 teens in Florida with a Medicaid-covered delivery in fiscal years 1995 and 2001. MEASURES: Prepregnancy enrollment was defined as enrollment 9 or more months before delivery; late or no PNC was defined as initiation of PNC within 3 months of delivery or not at all. RESULTS: For teens enrolled in traditional welfare-related categories, the proportion with prepregnancy Medicaid enrollment increased and the proportion with late or no PNC declined from 1995 to 2001. Teens enrolled under the Omnibus Budget Reconciliation Act (OBRA) expansion category in 2001 were less likely than welfare-related teen enrollees to have prepregnancy coverage but were more likely to initiate PNC early. Racial disparities were found in PNC initiation among the 1995 welfare-related group and the 2001 expansion group but were eliminated or greatly reduced among the 2001 welfare-related group. CONCLUSIONS: Providing public insurance coverage improves access to care but is not sufficient to meet Healthy People 2010 goals or eliminate racial and ethnic disparities in PNC initiation.

The association between perceived discrimination and underutilization of needed medical and mental health care in a multi-ethnic community sample.

This study examines the association between perceived discrimination and underutilization of needed medical and mental health care, in a representative, multi-ethnic community sample. Data were derived from a cross sectional survey of 10,098 White, U.S.-born Black, African-born Black, American Indian, Hispanic, and Southeast Asian adults in Hennepin County, Minnesota. Even after controlling for socio-demographic characteristics, health care access, and physical and mental health, perceived discrimination was associated with underutilization of medical care among Whites, U.S.-born Blacks, and American Indians and was associated with underutilization of mental health care among Whites, U.S.-born Blacks, Southeast Asians, and American Indians. Correlates of different types of discrimination (major, everyday, health care) on underutilization of care varied among ethnic groups. The higher prevalence of discrimination among racial and ethnic minorities may contribute to their underutilization of health care services. Future research is needed to understand the impacts of different types of discrimination on different groups.

The educational background and qualifications of UK medical students from ethnic minorities.

BACKGROUND: UK medical students and doctors from ethnic minorities underperform in undergraduate and postgraduate examinations. Although it is assumed that white (W) and non-white (NW) students enter medical school with similar qualifications, neither the qualifications of NW students, nor their educational background have been looked at in detail. This study uses two large-scale databases to examine the educational attainment of W and NW students. METHODS: Attainment at GCSE and A level, and selection for medical school in relation to ethnicity, were analysed in two separate databases. The 10th cohort of the Youth Cohort Study provided data on 13,698 students taking GCSEs in 1999 in England and Wales, and their subsequent progression to A level. UCAS provided data for 1,484,650 applicants applying for admission to UK universities and colleges in 2003, 2004 and 2005, of whom 52,557 applied to medical school, and 23,443 were accepted. RESULTS: NW students achieve lower grades at GCSE overall, although achievement at the highest grades was similar to that of W students. NW students have higher educational aspirations, being more likely to go on to take A levels, especially in science and particularly chemistry, despite relatively lower achievement at GCSE. As a result, NW students perform less well at A level than W students, and hence NW students applying to university also have lower A-level grades than W students, both generally, and for medical school applicants. NW medical school entrants have lower A level grades than W entrants, with an effect size of about -0.10. CONCLUSION: The effect size for the difference between white and non-white medical school entrants is about B0.10, which would mean that for a typical medical school examination there might be about 5 NW failures for each 4 W failures. However, this effect can only explain a portion of the overall effect size found in undergraduate and postgraduate examinations of about -0.32.

Ethnogenetic layering (EL): an alternative to the traditional race model in human variation and health disparity studies.

BACKGROUND: Traditionally, studies in human biodiversity, disease risk, and health disparities have defined populations in the context of typological racial models. However, such racial models are often imprecise generalizations that fail to capture important local patterns of human biodiversity. AIM: More explicit, detailed, and integrated information on relevant geographic, environmental, cultural, genetic, historical, and demographic variables are needed to understand local group expressions of disease inequities. This paper details the methods used in ethnogenetic layering (EL), a non-typological alternative to the current reliance of the biological racial paradigm in public health, epidemiology, and biomedicine. SUBJECTS AND METHODS: EL is focused on geographically identified microethnic groups or MEGs, a more nuanced and sensitive level of analysis than race. Using the MEG level of analysis, EL reveals clinical variations, details the causes of health disparities, and provides a foundation for bioculturally effective intervention strategies. EL relies on computational approaches by using GIS-facilitated maps to produce horizontally stratified geographical regional profiles which are then stacked and evaluated vertically. Each horizontal digital map details local geographic variation in the attributes of a particular database; usually this includes data on local historical demography, genetic diversity, cultural patterns, and specific chronic disease risks (e.g. dietary and toxicological exposures). Horizontal visual display of these layered maps permits vertical analysis at various geographic hot spots. RESULTS AND CONCLUSIONS: From these analyses, geographical areas and their associated MEGs with highly correlated chronic disease risk factors can be identified and targeted for further study.

Disparities in self-reported diabetes mellitus among Arab, Chaldean, and black Americans in Southeast Michigan.

Diabetes mellitus is an important public health problem that disproportionately affects minorities. Using a cross sectional, convenience sample, we estimated the prevalence of self-reported diabetes for Whites (n = 212), Arabs (n = 1,303), Chaldeans (n = 828), and Blacks (n = 789) in southeast Michigan. In addition, using a logistic regression model, we estimated odds ratios and 95% confidence intervals for the association between ethnicity and diabetes before and after adjusting for demographic, socioeconomic status, health care, chronic conditions, and health behavior variables. The overall age- and sex-adjusted prevalence of diabetes was 7.0%. Estimates were highest for Blacks (8.0%) followed by Arabs and Whites (7.0% for each group) and Chaldeans (6.0%). In the fully adjusted model, the association between ethnicity and diabetes was not statistically significant. Future studies should collect more detailed socioeconomic status, acculturation and health behavior information, which are factors that may affect the relationship between race/ethnicity and diabetes.

The ambiguous meanings of the racial/ethnic categories routinely used in human genetics research.

Many researchers are currently studying the distribution of genetic variations among diverse groups, with particular interest in explaining racial/ethnic health disparities. However, the use of racial/ethnic categories as variables in biological research is controversial. Just how racial/ethnic categories are conceptualized, operationalized, and interpreted is a key consideration in determining the legitimacy of their use, but has received little attention. We conducted semi-structured, open-ended interviews with 30 human genetics scientists from the US and Canada who use racial/ethnic variables in their research. They discussed the types of classifications they use, the criteria upon which they are based, and their methods for classifying individual samples and subjects. We found definitions of racial/ethnic variables were often lacking or unclear, the specific categories they used were inconsistent and context specific, and classification practices were often implicit and unexamined. We conclude that such conceptual and practical problems are inherent to routinely used racial/ethnic categories themselves, and that they lack sufficient rigor to be used as key variables in biological research. It is our position that it is unacceptable to persist in the constructing of scientific arguments based on these highly ambiguous variables.

Ethnicity and mental health treatment utilization by patients with personality disorders.

The authors examined the relationship between ethnicity and treatment utilization by individuals with personality disorders (PDs). Lifetime and prospectively determined rates and amounts of mental health treatments received were compared in over 500 White, African American, and Hispanic participants with PDs in a naturalistic longitudinal study. Minority, especially Hispanic, participants were significantly less likely than White participants to receive a range of outpatient and inpatient psychosocial treatments and psychotropic medications. This pattern was especially pronounced for minority participants with more severe PDs. A positive support alliance factor significantly predicted the amount of individual psychotherapy used by African American and Hispanic but not White participants, underscoring the importance of special attention to the treatment relationship with minority patients. These treatment use differences raise complex questions about treatment assessment and delivery, cultural biases of the current diagnostic system, and possible variation in PD manifestation across racial/ethnic groups. Future studies need to assess specific barriers to adequate and appropriate treatments for minority individuals with PDs.