Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months.

Objective: Functional connectivity magnetic resonance imaging (fcMRI) of neonates with perinatal brain injury could improve prediction of motor impairment before symptoms manifest, and establish how early brain organization relates to subsequent development. This cohort study is the first to describe and quantitatively assess functional brain networks and their relation to later motor skills in neonates with a diverse range of perinatal brain injuries. Methods: Infants (n = 65, included in final analyses: n = 53) were recruited from the neonatal intensive care unit (NICU) and were stratified based on their age at birth (premature vs. term), and on whether neuropathology was diagnosed from structural MRI. Functional brain networks and a measure of disruption to functional connectivity were obtained from 14 min of fcMRI acquired during natural sleep at term-equivalent age. Results: Disruption to connectivity of the somatomotor and frontoparietal executive networks predicted motor impairment at 4 and 8 months. This disruption in functional connectivity was not found to be driven by differences between clinical groups, or by any of the specific measures we captured to describe the clinical course. Conclusion: fcMRI was predictive over and above other clinical measures available at discharge from the NICU, including structural MRI. Motor learning was affected by disruption to somatomotor networks, but also frontoparietal executive networks, which supports the functional importance of these networks in early development. Disruption to these two networks might be best addressed by distinct intervention strategies.

Auditory structural connectivity in preterm and healthy term infants during the first postnatal year.

Assessing language development in the first postnatal year is difficult, as receptive and expressive skills are rudimentary. Although outward manifestations of change are limited, the auditory language system is thought to undergo critical development at this age, as the foundations are laid for the rapid onset of spoken language in the second and third years. We recruited 11 infants, 7 healthy controls (gestational age = 40.69 ± 0.56; range from 40 to 41.43) and preterm babies (gestational age = 28.04 ± 0.95; range from 27.43 to 29.43) who underwent a Magnetic Resonance Imaging study during the first postnatal year (age at scan = 194.18 ± 97.98). We assessed white matter tracts using diffusion-weighted magnetic resonance imaging with probabilistic tractography. Fractional anisotropy was found to be largely mature even at one month, although there was a little further increase during the first postnatal year in both the acoustic radiation and the direct brainstem-Heschl's pathway.

Adult-like processing of naturalistic sounds in auditory cortex by 3- and 9-month old infants.

Functional neuroimaging has been used to show that the developing auditory cortex of very young human infants responds, in some way, to sound. However, impoverished stimuli and uncontrolled designs have made it difficult to attribute brain responses to specific auditory features, and thus made it difficult to assess the maturity of feature tuning in auditory cortex. To address this, we used functional magnetic resonance imaging (fMRI) to measure the brain activity evoked by naturalistic sounds (a series of sung lullabies) in two groups of infants (3 and 9 months) and adults. We developed a novel analysis method - inter-subject regression (ISR) - to quantify the similarity of cortical responses between infants and adults, and to decompose components of the response due to different auditory features. We found that the temporal pattern of activity in infant auditory cortex shared similarity with adults. Some of this shared response could be attributed to simple acoustic features, such as frequency, pitch, envelope, but other parts were not, suggesting that even more complex adult-like features are represented in auditory cortex in early infancy.

British English infants segment words only with exaggerated infant-directed speech stimuli.

The word segmentation paradigm originally designed by Jusczyk and Aslin (1995) has been widely used to examine how infants from the age of 7.5 months can extract novel words from continuous speech. Here we report a series of 13 studies conducted independently in two British laboratories, showing that British English-learning infants aged 8-10.5 months fail to show evidence of word segmentation when tested in this paradigm. In only one study did we find evidence of word segmentation at 10.5 months, when we used an exaggerated infant-directed speech style. We discuss the impact of variations in infant-directed style within and across languages in the course of language acquisition.

An ERP investigation of regional and foreign accent processing.

This study used event-related potentials (ERPs) to examine whether we employ the same normalisation mechanisms when processing words spoken with a regional accent or foreign accent. Our results showed that the Phonological Mapping Negativity (PMN) following the onset of the final word of sentences spoken with an unfamiliar regional accent was greater than for those produced in the listener's own accent, whilst PMN for foreign accented speech was reduced. Foreign accents also resulted in a reduction in N400 amplitude when compared to both unfamiliar regional accents and the listener's own accent, with no significant difference found between the N400 of the regional and home accents. These results suggest that regional accent related variations are normalised at the earliest stages of spoken word recognition, requiring less top-down lexical intervention than foreign accents.

The use of social and salience cues in early word learning.

This article explores young infants' ability to learn new words in situations providing tightly controlled social and salience cues to their reference. Four experiments investigated whether, given two potential referents, 15-month-olds would attach novel labels to (a) an image toward which a digital recording of a face turned and gazed, (b) a moving image versus a stationary image, (c) a moving image toward which the face gazed, and (d) a gazed-on image versus a moving image. Infants successfully used the recorded gaze cue to form new word-referent associations and also showed learning in the salience condition. However, their behavior in the salience condition and in the experiments that followed suggests that, rather than basing their judgments of the words' reference on the mere presence or absence of the referent's motion, infants were strongly biased to attend to the consistency with which potential referents moved when a word was heard.

Memory for targets in a multi-level simulated-environment: a comparison between able-bodied and physically disabled children.

Two groups of children, one able-bodied and the other with physical disabilities, explored a symmetrical three-tiered virtual building that contained six distinctive target objects, two on each story. In a subsequent test, the target objects were removed and participants were asked to make judgments of the directions to the former target locations from each floor in turn. At each test site, judgments were required for targets that were formerly on the same floor and for those on higher and lower floors. Relative tilt error scores suggested a bias for both groups, in that targets that were higher than the test location were judged as consistently lower than their actual position, whereas targets that were lower than the test location were judged as higher than their actual position. Absolute tilt errors revealed an asymmetry in both groups, with more accurate tilt errors for judgments directed to lower than higher floors. The relevance of these results for the source of the asymmetry is discussed.

Memory for targets in a multilevel simulated environment: evidence for vertical asymmetry in spatial memory.

In two experiments, adult participants explored a symmetrical three-tiered computer-simulated building that contained six distinctive objects, two on each floor. Following exploration, the objects were removed, and the participants were asked to make direction judgments from each floor, indicating the former positions of the objects on that floor and on higher and lower floors. Relative tilt error scores indicated a bias, in that targets that were higher than the test location were judged as consistently lower than their actual positions and targets that were lower than the test location were judged as consistently higher than their actual positions. Absolute tilt errors revealed an asymmetry, with more accurate and less variable tilt errors for judgments directed to lower floors than for judgments directed to higher floors. Experiment 3 ruled out an account of the findings that does not relate them to spatial memory. The results suggest that the superiority of downward over upward spatial judgments, previously reported in two-dimensional visual-spatial tasks, extends to navigational spatial memory.

Spatial knowledge of a real school environment acquired from virtual or physical models by able-bodied children and children with physical disabilities.

In Experiment 1, 2 groups of able-bodied children were exposed to both a complex single-tier virtual environment (VE) and a physical model of a different environment. For 1 group, the VE accurately modeled a real school, and for the other group the physical model did so. In transfer testing in the real school, orientation accuracy was greater in the group exposed to the VE of the real school. In Experiment 2, children with physical disabilities explored the VE model of the real school and were tested as in the 1st experiment. Measures of orientation accuracy and map-placing were significantly better in this group than in the guessing adult control group. The results illustrate the potential for VEs as useful spatial training media.