1.
Neurosci Lett
; 759: 136015, 2021 08 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34111509
RESUMEN
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates several cellular processes including survival, proliferation, and metabolism. In the brain, PTEN is a key modulator of synaptic function, and is involved in regulating synaptogenesis, connectivity, and synaptic plasticity. Herein we discuss how alterations in PTEN can disturb these mechanisms, thus compromising normal synaptic function and consequently contributing to behavioral and cognitive phenotypes observed in autism spectrum disorder (ASD). As the role of PTEN in synaptic function is linked to ASD, a deeper understanding of this interaction will shed light on the pathological mechanisms involved in ASD, contributing to the development of new therapies.