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1.
Ultrason Imaging ; : 1617346241271240, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-39257166

RESUMEN

In this research work, Semantic-Preserved Generative Adversarial Network optimized by Piranha Foraging Optimization for Thyroid Nodule Classification in Ultrasound Images (SPGAN-PFO-TNC-UI) is proposed. Initially, ultrasound images are gathered from the DDTI dataset. Then the input image is sent to the pre-processing step. During pre-processing stage, the Multi-Window Savitzky-Golay Filter (MWSGF) is employed to reduce the noise and improve the quality of the ultrasound (US) images. The pre-processed output is supplied to the Generalized Intuitionistic Fuzzy C-Means Clustering (GIFCMC). Here, the ultrasound image's Region of Interest (ROI) is segmented. The segmentation output is supplied to the Fully Numerical Laplace Transform (FNLT) to extract the features, such as geometric features like solidity, orientation, roundness, main axis length, minor axis length, bounding box, convex area, and morphological features, like area, perimeter, aspect ratio, and AP ratio. The Semantic-Preserved Generative Adversarial Network (SPGAN) separates the image as benign or malignant nodules. Generally, SPGAN does not express any optimization adaptation methodologies for determining the best parameters to ensure the accurate classification of thyroid nodules. Therefore, the Piranha Foraging Optimization (PFO) algorithm is proposed to improve the SPGAN classifier and accurately identify the thyroid nodules. The metrics, like F-score, accuracy, error rate, precision, sensitivity, specificity, ROC, computing time is examined. The proposed SPGAN-PFO-TNC-UI method attains 30.54%, 21.30%, 27.40%, and 18.92% higher precision and 26.97%, 20.41%, 15.09%, and 18.27% lower error rate compared with existing techniques, like Thyroid detection and classification using DNN with Hybrid Meta-Heuristic and LSTM (TD-DL-HMH-LSTM), Quantum-Inspired convolutional neural networks for optimized thyroid nodule categorization (QCNN-OTNC), Thyroid nodules classification under Follow the Regularized Leader Optimization based Deep Neural Networks (CTN-FRL-DNN), Automatic classification of ultrasound thyroids images using vision transformers and generative adversarial networks (ACUTI-VT-GAN) respectively.

2.
Comput Biol Med ; 180: 108980, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39137668

RESUMEN

Automatic tumor segmentation via positron emission tomography (PET) and computed tomography (CT) images plays a critical role in the prevention, diagnosis, and treatment of this disease via radiation oncology. However, segmenting these tumors is challenging due to the heterogeneity of grayscale levels and fuzzy boundaries. To address these issues, in this paper, an efficient model-informed PET/CT tumor co-segmentation method that combines fuzzy C-means clustering and Bayesian classification information is proposed. To alleviate the grayscale heterogeneity of multi-modal images, in this method, a novel grayscale similar region term is designed based on the background region information of PET and the foreground region information of CT. An edge stop function is innovatively presented to enhance the localization of fuzzy edges by incorporating the fuzzy C-means clustering strategy. To improve the segmentation accuracy further, a unique data fidelity term is introduced based on PET images by combining the distribution characteristics of pixel points in PET images. Finally, experimental validation on datasets of head and neck tumor (HECKTOR) and non-small cell lung cancer (NSCLC) demonstrated impressive values for three key evaluation metrics, including DSC, RVD and HD5, achieved impressive values of 0.85, 5.32, and 0.17, respectively. These compelling results indicate that image segmentation methods based on mathematical models exhibit outstanding performance in handling grayscale heterogeneity and fuzzy boundaries in multi-modal images.


Asunto(s)
Lógica Difusa , Tomografía Computarizada por Tomografía de Emisión de Positrones , Humanos , Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos , Análisis por Conglomerados , Teorema de Bayes , Algoritmos , Neoplasias de Cabeza y Cuello/diagnóstico por imagen , Neoplasias Pulmonares/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Carcinoma de Pulmón de Células no Pequeñas/diagnóstico por imagen
3.
J Ultrasound Med ; 43(9): 1711-1722, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38873702

RESUMEN

OBJECTIVES: To develop a robust algorithm for estimating ultrasonic axial transmission velocity from neonatal tibial bone, and to investigate the relationships between ultrasound velocity and neonatal anthropometric measurements as well as clinical biochemical markers of skeletal health. METHODS: This study presents an unsupervised learning approach for the automatic detection of first arrival time and estimation of ultrasonic velocity from axial transmission waveforms, which potentially indicates bone quality. The proposed method combines the ReliefF algorithm and fuzzy C-means clustering. It was first validated using an in vitro dataset measured from a Sawbones phantom. It was subsequently applied on in vivo signals collected from 40 infants, comprising 21 males and 19 females. The extracted neonatal ultrasonic velocity was subjected to statistical analysis to explore correlations with the infants' anthropometric features and biochemical indicators. RESULTS: The results of in vivo data analysis revealed significant correlations between the extracted ultrasonic velocity and the neonatal anthropometric measurements and biochemical markers. The velocity of first arrival signals showed good associations with body weight (ρ = 0.583, P value <.001), body length (ρ = 0.583, P value <.001), and gestational age (ρ = 0.557, P value <.001). CONCLUSION: These findings suggest that fuzzy C-means clustering is highly effective in extracting ultrasonic propagating velocity in bone and reliably applicable in in vivo measurement. This work is a preliminary study that holds promise in advancing the development of a standardized ultrasonic tool for assessing neonatal bone health. Such advancements are crucial in the accurate diagnosis of bone growth disorders.


Asunto(s)
Tibia , Ultrasonografía , Aprendizaje Automático no Supervisado , Humanos , Recién Nacido , Ultrasonografía/métodos , Femenino , Masculino , Tibia/diagnóstico por imagen , Tibia/fisiología , Fantasmas de Imagen , Algoritmos , Reproducibilidad de los Resultados
4.
Network ; : 1-37, 2024 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-38804548

RESUMEN

Automated diagnosis of cancer from skin lesion data has been the focus of numerous research. Despite that it can be challenging to interpret these images because of features like colour illumination changes, variation in the sizes and forms of the lesions. To tackle these problems, the proposed model develops an ensemble of deep learning techniques for skin cancer diagnosis. Initially, skin imaging data are collected and preprocessed using resizing and anisotropic diffusion to enhance the quality of the image. Preprocessed images are fed into the Fuzzy-C-Means clustering technique to segment the region of diseases. Stacking-based ensemble deep learning approach is used for classification and the LSTM acts as a meta-classifier. Deep Neural Network (DNN) and Convolutional Neural Network (CNN) are used as input for LSTM. This segmented images are utilized to be input into the CNN, and the local binary pattern (LBP) technique is employed to extract DNN features from the segments of the image. The output from these two classifiers will be fed into the LSTM Meta classifier. This LSTM classifies the input data and predicts the skin cancer disease. The proposed approach had a greater accuracy of 97%. Hence, the developed model accurately predicts skin cancer disease.

5.
J Environ Manage ; 359: 121054, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38728982

RESUMEN

Semi-arid regions present unique challenges for maintaining aquatic biological integrity due to their complex evolutionary mechanisms. Uncovering the spatial patterns of aquatic biological integrity in these areas is a challenging research task, especially under the compound environmental stress. Our goal is to address this issue with a scientifically rigorous approach. This study aims to explore the spatial analysis and diagnosis method of aquatic biological based on the combination of machine learning and statistical analysis, so as to reveal the spatial differentiation patterns and causes of changes of aquatic biological integrity in semi-arid regions. To this end, we have introduced an innovative approach that combines XGBoost-SHAP and Fuzzy C-means clustering (FCM), we successfully identified and diagnosed the spatial variations of aquatic biological integrity in the Wei River Basin (WRB). The study reveals significant spatial variations in species number, diversity, and aquatic biological integrity of phytoplankton, serving as a testament to the multifaceted responses of biological communities under the intricate tapestry of environmental gradients. Delving into the depths of the XGBoost-SHAP algorithm, we discerned that Annual average Temperature (AT) stands as the pivotal driver steering the spatial divergence of the Phytoplankton Integrity Index (P-IBI), casting a positive influence on P-IBI when AT is below 11.8 °C. The intricate interactions between hydrological variables (VF and RW) and AT, as well as between water quality parameters (WT, NO3-N, TP, COD) and AT, collectively sculpt the spatial distribution of P-IBI. The fusion of XGBoost-SHAP with FCM unveils pronounced north-south gradient disparities in aquatic biological integrity across the watershed, segmenting the region into four distinct zones. This establishes scientific boundary conditions for the conservation strategies and management practices of aquatic ecosystems in the region, and its flexibility is applicable to the analysis of spatial heterogeneity in other complex environmental contexts.


Asunto(s)
Aprendizaje Automático , Fitoplancton , Ríos , Monitoreo del Ambiente/métodos , Algoritmos
6.
Sensors (Basel) ; 24(5)2024 Mar 05.
Artículo en Inglés | MEDLINE | ID: mdl-38475218

RESUMEN

Accurate and automatic first-arrival picking is one of the most crucial steps in microseismic monitoring. We propose a method based on fuzzy c-means clustering (FCC) to accurately divide microseismic data into useful waveform and noise sections. The microseismic recordings' polarization linearity, variance, and energy are employed as inputs for the fuzzy clustering algorithm. The FCC produces a membership degree matrix that calculates the membership degree of each feature belonging to each cluster. The data section with the higher membership degree is identified as the useful waveform section, whose first point is determined as the first arrival. The extracted polarization linearity improves the classification performance of the fuzzy clustering algorithm, thereby enhancing the accuracy of first-arrival picking. Comparison tests using synthetic data with different signal-to-noise ratios (SNRs) demonstrate that the proposed method ensures that 94.3% of the first arrivals picked have an error within 2 ms when SNR = -5 dB, surpassing the residual U-Net, Akaike information criterion, and short/long time average ratio approaches. In addition, the proposed method achieves a picking accuracy of over 95% in the real dataset tests without requiring labelled data.

7.
Sci Rep ; 14(1): 6290, 2024 03 15.
Artículo en Inglés | MEDLINE | ID: mdl-38491186

RESUMEN

BC (Breast cancer) is the second most common reason for women to die from cancer. Recent workintroduced a model for BC classifications where input breast images were pre-processed using median filters for reducing noises. Weighed KMC (K-Means clustering) is used to segment the ROI (Region of Interest) after the input image has been cleaned of noise. Block-based CDF (Centre Distance Function) and CDTM (Diagonal Texture Matrix)-based texture and shape descriptors are utilized for feature extraction. The collected features are reduced in counts using KPCA (Kernel Principal Component Analysis). The appropriate feature selection is computed using ICSO (Improved Cuckoo Search Optimization). The MRNN ((Modified Recurrent Neural Network)) values are then improved through optimization before being utilized to divide British Columbia into benign and malignant types. However, ICSO has many disadvantages, such as slow search speed and low convergence accuracy and training an MRNN is a completely tough task. To avoid those problems in this work preprocessing is done by bilateral filtering to remove the noise from the input image. Bilateral filter using linear Gaussian for smoothing. Contrast stretching is applied to improve the image quality. ROI segmentation is calculated based on MFCM (modified fuzzy C means) clustering. CDTM-based, CDF-based color histogram and shape description methods are applied for feature extraction. It summarizes two important pieces of information about an object such as the colors present in the image, and the relative proportion of each color in the given image. After the features are extracted, KPCA is used to reduce the size. Feature selection was performed using MCSO (Mutational Chicken Flock Optimization). Finally, BC detection and classification were performed using FCNN (Fuzzy Convolutional Neural Network) and its parameters were optimized using MCSO. The proposed model is evaluated for accuracy, recall, f-measure and accuracy. This work's experimental results achieve high values of accuracy when compared to other existing models.


Asunto(s)
Algoritmos , Neoplasias de la Mama , Femenino , Humanos , Neoplasias de la Mama/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador/métodos , Redes Neurales de la Computación , Colombia Británica
8.
Environ Res ; 251(Pt 1): 118577, 2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38432567

RESUMEN

Due to the emergency environment pollution problems, it is imperative to understand the air quality and take effective measures for environmental governance. As a representative measure, the air quality index (AQI) is a single conceptual index value simplified by the concentrations of several routinely monitored air pollutants according to the proportion of various components in the air. With the gradual enhancement of awareness of environmental protection, air quality index forecasting is a key point of environment management. However, most of the traditional forecasting methods ignore the fuzziness of original data itself and the uncertainty of forecasting results which causes the unsatisfactory results. Thus, an innovative forecasting system combining data preprocessing technique, kernel fuzzy c-means (KFCM) clustering algorithm and fuzzy time series is successfully developed for air quality index forecasting. Concretely, the fuzzy time series that handle the fuzzy set is used for the main forecasting process. Then the complete ensemble empirical mode decomposition and KFCM are respectively developed for data denoising and interval partition. Furthermore, the interval forecasting method based on error distribution is developed to measure the forecasting uncertainty. Finally, the experimental simulation and evaluation system verify the great performance of proposed forecasting system and the promising applicability in a practical environment early warning system.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Monitoreo del Ambiente , Predicción , Lógica Difusa , Contaminación del Aire/análisis , Predicción/métodos , Monitoreo del Ambiente/métodos , Contaminantes Atmosféricos/análisis , Algoritmos
9.
Photodiagnosis Photodyn Ther ; 46: 104048, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38484830

RESUMEN

BACKGROUND: Breast cancer is a leading cause of cancer-related deaths among women worldwide. Early and accurate detection is crucial for improving patient outcomes. Our study utilizes Visible and Near-Infrared Hyperspectral Imaging (VIS-NIR HSI), a promising non-invasive technique, to detect cancerous regions in ex-vivo breast specimens based on their hyperspectral response. METHODS: In this paper, we present a novel HSI platform integrated with fuzzy c-means clustering for automated breast cancer detection. We acquire hyperspectral data from breast tissue samples, and preprocess it to reduce noise and enhance hyperspectral features. Fuzzy c-means clustering is then applied to segment cancerous regions based on their spectral characteristics. RESULTS: Our approach demonstrates promising results. We evaluated the quality of the clustering using metrics like Silhouette Index (SI), Davies-Bouldin Index (DBI), and Calinski-Harabasz Index (CHI). The clustering metrics results revealed an optimal number of 6 clusters for breast tissue classification, and the SI values ranged from 0.68 to 0.72, indicating well-separated clusters. Moreover, the CHI values showed that the clusters were well-defined, and the DBI values demonstrated low cluster dispersion. Additionally, the sensitivity, specificity, and accuracy of our system were evaluated on a dataset of breast tissue samples. We achieved an average sensitivity of 96.83%, specificity of 93.39%, and accuracy of 95.12%. These results indicate the effectiveness of our HSI-based approach in distinguishing cancerous and non-cancerous regions. CONCLUSIONS: The paper introduces a robust hyperspectral imaging platform coupled with fuzzy c-means clustering for automated breast cancer detection. The clustering metrics results support the reliability of our approach in effectively segmenting breast tissue samples. In addition, the system shows high sensitivity and specificity, making it a valuable tool for early-stage breast cancer diagnosis. This innovative approach holds great potential for improving breast cancer screening and, thereby, enhancing our understanding of the disease and its detection patterns.


Asunto(s)
Neoplasias de la Mama , Imágenes Hiperespectrales , Espectroscopía Infrarroja Corta , Humanos , Neoplasias de la Mama/diagnóstico por imagen , Femenino , Imágenes Hiperespectrales/métodos , Espectroscopía Infrarroja Corta/métodos , Lógica Difusa
10.
Med Biol Eng Comput ; 62(2): 371-388, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-37874453

RESUMEN

Machine learning-based Parkinson's disease (PD) speech diagnosis is a current research hotspot. However, existing methods use each corpus sample as the base unit for modeling. Since different corpus samples within the same subject have different sensitive speech features, it is difficult to obtain unified and stable sensitive speech features (diagnostic markers) that reflect the pathology of the whole subject. Therefore, this study aims at compressing the corpus samples within the subject to facilitate the search for diagnostic markers with high diagnostic accuracy. A two-step sample compression module (TSCM) can solve the problem above. It includes two major parts: sample pruning module (SPM) and sample fuzzy clustering mechanism (SFCMD). Based on stacking multiple TSCMs, a multilayer sample compression module (MSCM) is formed to obtain multilayer compression samples. After that, simultaneous sample/feature selection mechanism (SS/FSM) is designed for feature selection. Based on the multilayer compression samples processed by MSCM and SS/FSM, a novel ensemble learning algorithm (EMSFE) is designed with sparse fusion ensemble learning mechanism (SFELM). The proposed EMSFE is validated by visualization of extracted features and performance comparison with related algorithms. The experimental results show that the proposed algorithm can effectively extract the stable diagnostic markers by compressing the corpus samples within the subject. Furthermore, based on LOSO cross validation, the proposed algorithm with extreme learning machine (ELM) classifier can achieve the accuracy of 92.5%, 93.75% and 91.67% on three datasets, respectively. The proposed EMSFE can extract unified and stable sensitive features that accurately reflect the overall pathology of the subject, which can better meet the requirements of clinical applications.The code and datasets can be found in: https://github.com/wywwwww/EMSFE-supplementary-material.git.


Asunto(s)
Compresión de Datos , Enfermedad de Parkinson , Humanos , Enfermedad de Parkinson/diagnóstico , Habla , Algoritmos , Aprendizaje Automático
11.
Microsc Res Tech ; 87(1): 78-94, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-37681440

RESUMEN

Diabetic retinopathy (DR) is a prevalent cause of global visual impairment, contributing to approximately 4.8% of blindness cases worldwide as reported by the World Health Organization (WHO). The condition is characterized by pathological abnormalities in the retinal layer, including microaneurysms, vitreous hemorrhages, and exudates. Microscopic analysis of retinal images is crucial in diagnosing and treating DR. This article proposes a novel method for early DR screening using segmentation and unsupervised learning techniques. The approach integrates a neural network energy-based model into the Fuzzy C-Means (FCM) algorithm to enhance convergence criteria, aiming to improve the accuracy and efficiency of automated DR screening tools. The evaluation of results includes the primary dataset from the Shiva Netralaya Centre, IDRiD, and DIARETDB1. The performance of the proposed method is compared against FCM, EFCM, FLICM, and M-FLICM techniques, utilizing metrics such as accuracy in noiseless and noisy conditions and average execution time. The results showcase auspicious performance on both primary and secondary datasets, achieving accuracy rates of 99.03% in noiseless conditions and 93.13% in noisy images, with an average execution time of 16.1 s. The proposed method holds significant potential in medical image analysis and could pave the way for future advancements in automated DR diagnosis and management. RESEARCH HIGHLIGHTS: A novel approach is proposed in the article, integrating a neural network energy-based model into the FCM algorithm to enhance the convergence criteria and the accuracy of automated DR screening tools. By leveraging the microscopic characteristics of retinal images, the proposed method significantly improves the accuracy of lesion segmentation, facilitating early detection and monitoring of DR. The evaluation of the method's performance includes primary datasets from reputable sources such as the Shiva Netralaya Centre, IDRiD, and DIARETDB1, demonstrating its effectiveness in comparison to other techniques (FCM, EFCM, FLICM, and M-FLICM) in terms of accuracy in both noiseless and noisy conditions. It achieves impressive accuracy rates of 99.03% in noiseless conditions and 93.13% in noisy images, with an average execution time of 16.1 s.


Asunto(s)
Diabetes Mellitus , Retinopatía Diabética , Humanos , Retinopatía Diabética/diagnóstico por imagen , Retinopatía Diabética/patología , Interpretación de Imagen Asistida por Computador/métodos , Algoritmos , Retina/diagnóstico por imagen , Retina/patología , Análisis por Conglomerados
12.
Front Plant Sci ; 14: 1202092, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37936937

RESUMEN

Introduction: Chilling injury is one of the most common meteorological disasters affecting cucumber production. For implementing remedial measures as soon as possible to minimize production loss, a timely and precise assessment of chilling injury is crucial. Methods: To evaluate the possibility of detecting cucumber chilling injury using chlorophyll fluorescence (ChlF) technology, we investigated the continuous changes in ChlF parameters under various low-temperature conditions and created the criteria for evaluating chilling injury. The ChlF induction curves were first collected before low-temperature as unstressed samples and daily 1 to 5 days after low-temperature as chilling injury samples. Principal component analysis was employed to investigate the public information on ChlF parameters and evaluate the differences between samples with different degrees of chilling injury. The parameters (F v/F m, Y(NO), qP, and F o) accounted for a large proportion in the principal components and could characterize chilling injury. Uniform manifold approximation and projection method was employed to extract new features (Feature 1, Feature 2, Feature 3, and Feature 4) from ChlF parameters for subsequent classification model. Taking four features as input, a classification model based on the Fuzzy C-means clustering algorithm was constructed in order to identify the chilling injury classes of cucumber seedlings. The cucumber seedlings with different chilling injury classes were analyzed for ChlF images, rapid light curves, and malondialdehyde content. Results and discussion: The results demonstrated that the variations in these indicators among the different chilling injury classes supported the validity of the classification model. Our findings provide a better understanding of the relationship between ChlF parameters and the impact of low-temperature treatment on cucumber seedlings. This finding offers an additional perspective that can be used to evaluate the responses and damage that plants experience under stress.

13.
Environ Sci Pollut Res Int ; 30(48): 106083-106098, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37723396

RESUMEN

The impact of climate change on water resource availability and soil quality is more and more emphasized under the Mediterranean basin, mostly characterized by drought and extreme weather conditions. The present study aims to investigate how electromagnetic induction technique and soil mapping combined with crop yield data can be used to optimize phosphorus (P) use efficiency by chickpea crop under drip fertigation system. The study was carried out on a 2.5-ha agricultural plot and the agronomic experiments in two growing cycles of chickpea crop. Soil spatial variability was first assessed by the measurement of soil apparent electrical conductivity (ECa) using the CMD Mini-Explorer sensor, and then, soil physicochemical properties were evaluated based on an oriented soil sampling scheme to explore other soil spatial variabilities influencing chickpea yield and quality. Data from the first agronomic experiment were used in geostatistical, multiple linear regression (MLR), and fuzzy c-means unsupervised classification algorithms to properly identify P drip fertigation management zones (MZs). Results from the Person's correlation analysis revealed that chickpea grain yield was more influenced by soil ECa (r = - 0.56), pH (r = - 0.84), ECe (r = - 0.6), P content (r = 0.72), and calcium (Ca) content (r = - 0.83). The proposed MLR-based model to predict chickpea grain yield showed good performances with a normalized root mean square error (NRMSE) of 0.11% and a coefficient of determination (R2) equal to 0.69. The identified MZs were verified by the one-way variance analysis for the studied soil and plant attributes, revealing that the first MZ1 presents a high grain yield, high soil P content, and low ECa. The low fertility MZ2 located in the south part of the studied site presented a low chickpea grain yield due to the low P content and the high ECa. Moreover, the application of P-variable rate fertigation regimes in the second field experiment significantly improved P use efficiency, chickpea grain yield, seed quality, and farmer income by 18%, 12%, 9%, and 136 $/ha, respectively, as compared to the conventional drip fertigation practices. The approach proposed in this study can greatly contribute to optimizing agro-input use efficiency under drip fertigation system, thereby improving farmers' incomes, preserving the ecosystem, and ensuring sustainable cropping systems in the Mediterranean climate.


Asunto(s)
Cicer , Suelo , Humanos , Suelo/química , Fósforo/análisis , Ecosistema , Agricultura , Fenómenos Electromagnéticos , Grano Comestible/química
14.
BMC Bioinformatics ; 24(1): 362, 2023 Sep 26.
Artículo en Inglés | MEDLINE | ID: mdl-37752445

RESUMEN

BACKGROUND: The central biological clock governs numerous facets of mammalian physiology, including sleep, metabolism, and immune system regulation. Understanding gene regulatory relationships is crucial for unravelling the mechanisms that underlie various cellular biological processes. While it is possible to infer circadian gene regulatory relationships from time-series gene expression data, relying solely on correlation-based inference may not provide sufficient information about causation. Moreover, gene expression data often have high dimensions but a limited number of observations, posing challenges in their analysis. METHODS: In this paper, we introduce a new hybrid framework, referred to as Circadian Gene Regulatory Framework (CGRF), to infer circadian gene regulatory relationships from gene expression data of rats. The framework addresses the challenges of high-dimensional data by combining the fuzzy C-means clustering algorithm with dynamic time warping distance. Through this approach, we efficiently identify the clusters of genes related to the target gene. To determine the significance of genes within a specific cluster, we employ the Wilcoxon signed-rank test. Subsequently, we use a dynamic vector autoregressive method to analyze the selected significant gene expression profiles and reveal directed causal regulatory relationships based on partial correlation. CONCLUSION: The proposed CGRF framework offers a comprehensive and efficient solution for understanding circadian gene regulation. Circadian gene regulatory relationships are inferred from the gene expression data of rats based on the Aanat target gene. The results show that genes Pde10a, Atp7b, Prok2, Per1, Rhobtb3 and Dclk1 stand out, which have been known to be essential for the regulation of circadian activity. The potential relationships between genes Tspan15, Eprs, Eml5 and Fsbp with a circadian rhythm need further experimental research.


Asunto(s)
Perfilación de la Expresión Génica , Regulación de la Expresión Génica , Ratas , Animales , Perfilación de la Expresión Génica/métodos , Factores de Transcripción/metabolismo , Algoritmos , Ritmo Circadiano/genética , Expresión Génica , Mamíferos/genética
15.
Entropy (Basel) ; 25(7)2023 Jul 04.
Artículo en Inglés | MEDLINE | ID: mdl-37509968

RESUMEN

This paper reviews the potential use of fuzzy c-means clustering (FCM) and explores modifications to the distance function and centroid initialization methods to enhance image segmentation. The application of interest in the paper is the segmentation of breast tumours in mammograms. Breast cancer is the second leading cause of cancer deaths in Canadian women. Early detection reduces treatment costs and offers a favourable prognosis for patients. Classical methods, like mammograms, rely on radiologists to detect cancerous tumours, which introduces the potential for human error in cancer detection. Classical methods are labour-intensive, and, hence, expensive in terms of healthcare resources. Recent research supplements classical methods with automated mammogram analysis. The basic FCM method relies upon the Euclidean distance, which is not optimal for measuring non-spherical structures. To address these limitations, we review the implementation of a Mahalanobis-distance-based FCM (FCM-M). The three objectives of the paper are: (1) review FCM, FCM-M, and three centroid initialization algorithms in the literature, (2) illustrate the effectiveness of these algorithms in image segmentation, and (3) develop a Python package with the optimized algorithms to upload onto GitHub. Image analysis of the algorithms shows that using one of the three centroid initialization algorithms enhances the performance of FCM. FCM-M produced higher clustering accuracy and outlined the tumour structure better than basic FCM.

16.
Environ Sci Pollut Res Int ; 30(20): 57529-57557, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36964807

RESUMEN

The current research is focused on detecting a river basin suitable for agriculture and priority for management using a new clustering tool of groundwater quality with fuzzy logic technique in R and Geographical Information System. A new fuzzy clustering-soft computing technique has been executed to determine the different hydrochemical zones considering 13 essential parameters such as electrical conductivity, hardness, chloride, sodium adsorption ratio, residual sodium carbonate, soluble sodium percent, magnesium hazard, permeability index, potential salinity, residual sodium bicarbonate, Kelly's ratio, synthetic harmful coefficient, and exchangeable sodium percentage. The derived fuzzy C-mean clustering (FCM) outperformed other available hard computing techniques like hierarchical clustering, K-means clustering, and agglomerative clustering. It divided the sampling sites into 2 clustering groups (FCM I and FCM II) which has been validated using fuzzy silhouette index (0.85), the partition coefficient (0.76), the partial entropy (0.68), and the modified partition coefficient (0.52). The hydrogeochemical analysis confirmed that the rock-water interaction, chemical weathering, and ion exchange process are predominant in the aquifer system of the study area. According to the correlation plots, the studied groundwater samples largely evolved from [Formula: see text], mixed [Formula: see text] types, and [Formula: see text] types. The spatial distribution map and the hydrochemical analysis also gives a clear depiction of the fluoride (> 1.0 mg/l) and high iron (> 0.3 mg/l) contamination in groundwater quality, making it unsuitable for both drinking and irrigation. A fuzzy EDAS priority map has been prepared based on all the irrigation suitability parameters which concludes that the groundwater at the upstream and downstream section of the basin requires the most attention. Based on the highest priority for management, five zones have been delineated: very high (5.98%), high (22.31%), medium (16.39%), low (32.30%), and very low (23.02). The findings of this study will be beneficial to planners and policymakers as they can develop schemes to solve similar problems across the country.


Asunto(s)
Agua Subterránea , Contaminantes Químicos del Agua , Abastecimiento de Agua , Monitoreo del Ambiente , Contaminantes Químicos del Agua/análisis , Agua Subterránea/análisis , Calidad del Agua , Agricultura , Sodio/análisis , Riego Agrícola , India
17.
Diagnostics (Basel) ; 13(6)2023 Mar 17.
Artículo en Inglés | MEDLINE | ID: mdl-36980463

RESUMEN

To improve the accuracy of tumor identification, it is necessary to develop a reliable automated diagnostic method. In order to precisely categorize brain tumors, researchers developed a variety of segmentation algorithms. Segmentation of brain images is generally recognized as one of the most challenging tasks in medical image processing. In this article, a novel automated detection and classification method was proposed. The proposed approach consisted of many phases, including pre-processing MRI images, segmenting images, extracting features, and classifying images. During the pre-processing portion of an MRI scan, an adaptive filter was utilized to eliminate background noise. For feature extraction, the local-binary grey level co-occurrence matrix (LBGLCM) was used, and for image segmentation, enhanced fuzzy c-means clustering (EFCMC) was used. After extracting the scan features, we used a deep learning model to classify MRI images into two groups: glioma and normal. The classifications were created using a convolutional recurrent neural network (CRNN). The proposed technique improved brain image classification from a defined input dataset. MRI scans from the REMBRANDT dataset, which consisted of 620 testing and 2480 training sets, were used for the research. The data demonstrate that the newly proposed method outperformed its predecessors. The proposed CRNN strategy was compared against BP, U-Net, and ResNet, which are three of the most prevalent classification approaches currently being used. For brain tumor classification, the proposed system outcomes were 98.17% accuracy, 91.34% specificity, and 98.79% sensitivity.

18.
Diagnostics (Basel) ; 13(3)2023 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-36766446

RESUMEN

Automated blood-vessel extraction is essential in diagnosing Diabetic Retinopathy (DR) and other eye-related diseases. However, the traditional methods for extracting blood vessels tend to provide low accuracy when dealing with difficult situations, such as extracting both micro and large blood vessels simultaneously with low-intensity images and blood vessels with DR. This paper proposes a complete preprocessing method to enhance original retinal images before transferring the enhanced images to a novel blood-vessel extraction method by a combined three extraction stages. The first stage focuses on the fast extraction of retinal blood vessels using Weighted Kernel Fuzzy C-Means (WKFCM) Clustering to draw the vessel feature from the retinal background. The second stage focuses on the accuracy of full-size images to achieve regional vessel feature recognition of large and micro blood vessels and to minimize false extraction. This stage implements the mathematical dilation operator from a trained model called Dilation-Based Function (DBF). Finally, an optimal parameter threshold is empirically determined in the third stage to remove non-vessel features in the binary image and improve the overall vessel extraction results. According to evaluations of the method via the datasets DRIVE, STARE, and DiaretDB0, the proposed WKFCM-DBF method achieved sensitivities, specificities, and accuracy performances of 98.12%, 98.20%, and 98.16%, 98.42%, 98.80%, and 98.51%, and 98.89%, 98.10%, and 98.09%, respectively.

19.
J Cancer Res Clin Oncol ; 149(9): 6049-6057, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36645508

RESUMEN

INTRODUCTION: A critical step to ameliorate diagnosis and extend patient survival is Benign-malignant Pulmonary Nodule (PN) classification at earlier detection. On account of the noise of Computed Tomography (CT) images, the prevailing Lung Nodule (LN) detection techniques exhibit broad variation in accurate prediction. METHODS: Thus, a novel Nodule Detection along with Classification algorithm for early diagnosis of Lung Cancer (LC) has been proposed. Initially, employing the Adaptive Mode Ostu Binarization (AMOB) technique, the Lung Volumes (LVs) isextortedas of the image together with the extracted lung regions is pre-processed. Then, detection of LNs takes place, and utilizing Geodesic Fuzzy C-Means Clustering (GFCM) Segmentation Algorithm, it is segmented.Next, the vital features are extracted, and the Nodules are classified by utilizing Logarithmic Layer Xception Neural Network (LLXcepNN) Classifier grounded on the extracted feature. RESULTS: The nodules are classified as Benign Nodules (BN) and Malignant Nodules (MN) by the proposed classifier. Lastly, the Lung CT images are scrutinized. DISCUSSION: Thus, when weighed against the prevailing techniques, the proposed systems' acquired outcomes exhibit that the rate of accuracy of classification is enhanced.


Asunto(s)
Neoplasias Pulmonares , Nódulos Pulmonares Múltiples , Humanos , Neoplasias Pulmonares/diagnóstico por imagen , Neoplasias Pulmonares/patología , Pulmón/patología , Redes Neurales de la Computación , Nódulos Pulmonares Múltiples/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Algoritmos
20.
Int J Inf Technol ; 15(1): 87-100, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36246340

RESUMEN

Social media plays an important role in disseminating information and analysing public and government opinions. The vast majority of previous research has examined information diffusion and opinion analysis separately. This study proposes a new framework for analysing both information diffusion and opinion evolution. The change in opinion over time is known as opinion evolution. To propose a new model for predicting information diffusion and opinion analysis in social media, a forest fire algorithm, cuckoo search, and fuzzy c-means clustering are used. The forest fire algorithm is used to determine the diffuser and non-diffuser of information in social networks, and fuzzy c-means clustering with the cuckoo search optimization algorithm is proposed to cluster Twitter content into various opinion categories and to determine opinion change. On different Twitter data sets, the proposed model outperformed the existing methods in terms of precision, recall, and accuracy.

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