Erythroplasia of Queyrat Involving the Distal Glans Penis Surrounding the Urethral Meatus / 대한피부과학회지

Erythroplasia of Queyrat is an uncommon form of carcinoma in situ involving the glans penis and adjacent mucosal structures. Treatment modalities of Erythroplasia of Queyrat vary widely and topical 5-fluorouracil treatment is very effective and regarded as the choice of t eatment. This article reports a case of erythroplasia of Queyrat involving the perimeatal region of the glans penis and identifies the difficulty of effectively treating erythroplasia of Queyrat which is adjaer to the urethral meatus with 5-fluorouracil and usefulness of electron beam irradiation therapy.

A case of malignant fibrous histiocytoma / 대한피부과학회지

The malignant fibrous histiocytoma is a predominantly pleomorphic arcoma usually occuring in the deep soft tissue of adults. Because of its highly variable morphologic pattern, this tumor has often been confused with other sarcomas such as pleomorphic rhabdomyosarcoma and liposarcoma. Although the histogenesis of this neoplasm remains controversial, it is best regarded as a primitive and pleomorphic nature reflected by collagen production and occasional phagocytosis. As report a case of malignant fibrous histiocytoma occurring in a 54-year-old female who presented with 4.5 x 5 x 0.5cm sized mass on the right thigh and metastasis later. Histopathologic findings shows plamp spindle cells appearing in a storiform-pleomorphic pattern around slitlike vessels. Immunohistochemical staining and electron microscopic findings led to the final diagnosis as malignant fibrous histiocytoma. The treatment was surgical excision.

A study on the changes of sebaceous gland activity during aging by analysis of skin surface lipids / 대한피부과학회지

BACKGROUND: The human sebaceous glands have long been known to change their activity with aging. Downing and his co-workers state that the ratio of wax ester/cholesterol+cholesterol ester in the skin surface lipids might be a good index for sebaceous gland acti ity. OBJECTIVE: Our purpose was to evaluate the effects of aging on the sebaceous gland activity and relative skin surface lipid composition by using thin layer chromatography. METHOD: Skin surface lipids of anterior chest from 65 healthy Korean indivisuals were collected by using the cup method. Skin surface lipid were separated and meaurd by thin layer chromatographic analysis. RESULTS: The sebaceous gland activity, vrhich was expressed by tlie ratio wax ester/[cholesterol+cholesterol ester] showed a ilistinct change from infancy to senescenc. The curve of the ratio makes a peak in the third decade and decreases with advancing age. CONCLUSION: This result disclosed that sebaceous gland activity iaifected by advancing age in Koreans and can be used as one of the biologic markers of aging.

A case of idiopathic midline destructive disease a subgroup of midline granuloma syndrome / 대한피부과학회지

Idiopathic midline destructive disease(IMDD) is a subgroup of midline granuloma syndrome, which is a clinical entity characterized by a relentless uilcer ation of the upper air way involving the nose, the palate, and the face, with a fatal outcorne. A 32 year-old male had symptoms of nasal obstruct.ion and rhinorrhea for about 4 months prior to visiting the hospital ad was referred to our Department for evaluation of a verely destruct.ive skin lesions on his face. The patient, revealed unique clinopatholcgic featurs compat with IMDD. These were : 1) prescence of locally destructive lesion which were restricted to the upper respiratory tract. 2) abscence of systemic disease durin the follow up peroid, 3) The histologic features consisted of acute and chronic inflarnmation with a variable dearel of necrosis on the examination of repeated biopsy specimens, 4) inabiliy to demonst rate an infectious causative organisms on repeated laboratory tests.