RESUMO
La neuromielitis óptica es una enfermedad inflamatoria, desmielinizante y autoinmune del sistema nervioso central. En el presente trabajo se realiza una revisión de los diferentes mecanismos involucrados en la patogénesis de la neuromielitis óptica, se analiza el papel de los eosinófilos, de los anticuerpos contra antígenos propios y de las células T reguladoras en la enfermedad. En la neuromielitis óptica existe un predominio de la respuesta inmune humoral, la enfermedad se caracteriza por el depósito de inmunocomplejos, activación del complemento, producción de anticuerpos contra proteínas de la mielina y reclutamiento de eosinófilos en las lesiones. Existe además un aumento de la expresión de receptores de quimiocinas como el CCR3, específico de células TH2, la enfermedad está asociada predominantemente a una respuesta TH2(AU)
The Optic Neuromyelitis is an inflammatory and autoimmune illness of the central nervous system. Presently work is carried out a revision of the different mechanisms involved in the pathogenesis of the Optic Neuromyelitis, the paper of the eosinophils is analyzed, of the antibodies against own antigens and of the regulatory T cells in the illness. In the Optic Neuromyelitis is very important the humoral response, the illness exists it is characterized by the immunocomplex deposit, activation of the complement, production of antibodies against proteins of the myelin and eosinophils recruitment in the lesions. It also exists an increase of the expression of chemokines receptors like the CCR3, specific of TH2 cells; the illness is associate predominantly to a TH2 response(AU)
Assuntos
Humanos , Neuromielite Óptica/imunologiaRESUMO
La neuromielitis óptica es una enfermedad inflamatoria, desmielinizante y autoinmune del sistema nervioso central. En el presente trabajo se realiza una revisión de los diferentes mecanismos involucrados en la patogénesis de la neuromielitis óptica, se analiza el papel de los eosinófilos, de los anticuerpos contra antígenos propios y de las células T reguladoras en la enfermedad. En la neuromielitis óptica existe un predominio de la respuesta inmune humoral, la enfermedad se caracteriza por el depósito de inmuno complejos, activación del complemento, producción de anticuerpos contra proteínas de la mielina y reclutamiento de eosinófilos en las lesiones. Existe además un aumento de la expresión de receptores de quimiocinas como el CCR3, específico de células TH2, la enfermedad está asociada predominantemente a una respuesta TH2
The Optic Neuromyelitis is an inflammatory and autoimmune illness of the central nervous system. Presently work is carried out a revision of the different mechanisms involved in the pathogenesis of the Optic Neuromyelitis, the paper of the eosinophils is analyzed, of the antibodies against own antigens and of the regulatory T cells in the illness. In the Optic Neuromyelitis is very important the humoral response, the illnes sexists it is characterized by the immunocomplex deposit, activation of the complement, production of antibodies against proteins of the myelin and eosinophils recruitment in the lesions. It also exists an increase of the expression of chemokines receptors like the CCR3, specific of TH2 cells; the illness is associate predominantly to a TH2 response
Assuntos
Neuromielite Óptica/diagnóstico , Neuromielite Óptica/epidemiologia , Neuromielite Óptica/imunologia , Imunidade nas Mucosas/fisiologia , Neuromielite Óptica/complicações , Neuromielite Óptica/fisiopatologia , Imunidade nas Mucosas/imunologia , Eosinófilos/patologiaRESUMO
La neuromielitis optica o síndrome de Devic es una enfermedad inflamatoria, desmielinizante y autoinmune del sistema nervioso central. Se caracteriza por ataques de neuritis óptica y mielitis, pudiendo producir ceguera, gran invalidez neurológica e incluso la muerte a corto plazo. Hasta el momento no existe un tratamiento efectivo, la terapia se centra en el tratamiento de los ataques agudos, la prevención médica de las complicaciones y la rehabilitación. Se realiza una revisión de esta enfermedad poco común, considerando que su prevalencia en nuestro país ha ido en aumento y se establece una comparación entre la neuromiel itisóptica y la esclerosis múltiple, basándose en las principales características clínico-epidemiológicas, que distinguen estas dos patologías, consideradas por muchos variantes clínicas de una misma enfermedad
The optic neuromyelitis or syndrome of Devic is an inflammatory and autoimmune illness of the central nervous system. It is characterized by attacks of optic neuritis and myelitis, being able to produce blindness, great neurological disability and even the short term death. Until the moment an effective treatment doesn't exist, the therapy is centred in the treatment of the acute attacks, the medical prevention of the complications and the rehabilitation. This article is a revision of this not very common illness, considering that its prevalence in our country has gone in increase. We compare between the optic neuromyelitis and the multiple sclerosis, being based on the main ones characteristic clinical-epidemic that distinguishes these two pathologies, considered by many clinical variants of oneself illness
Assuntos
Humanos , Masculino , Feminino , Neuromielite Óptica/complicações , Neuromielite Óptica/diagnóstico , Neuromielite Óptica/epidemiologia , Esclerose Múltipla/complicações , Esclerose Múltipla/diagnóstico , Autoimunidade/fisiologia , Neuromielite Óptica/fisiopatologia , Neurofisiologia/métodos , Plasmaferese/métodos , Plasmaferese/tendênciasRESUMO
La neuromielitis optica o síndrome de Devic es una enfermedad inflamatoria, desmielinizante y autoinmune del sistema nervioso central. Se caracteriza por ataques de neuritis óptica y mielitis, pudiendo producir ceguera, gran invalidez neurológica e incluso la muerte a corto plazo. Hasta el momento no existe un tratamiento efectivo, la terapia se centra en el tratamiento de los ataques agudos, la prevención médica de las complicaciones y la rehabilitación. Se realiza una revisión de esta enfermedad poco común, considerando que su prevalencia en nuestro país ha ido en aumento y se establece una comparación entre la neuromielitis óptica y la esclerosis múltiple, basándose en las principales características clínico-epidemiológicas, que distinguen estas dos patologías, consideradas por muchos variantes clínicas de una misma enfermedad(AU)
The optic neuromyelitis or syndrome of Devic is an inflammatory and autoimmune illness of the central nervous system. It is characterized by attacks of optic neuritis and myelitis, being able to produce blindness, great neurological disability and even the short term death. Until the moment an effective treatment doesn't exist, the therapy is centred in the treatment of the acute attacks, the medical prevention of the complications and the rehabilitation. This article is a revision of this not very common illness, considering that its prevalence in our country has gone in increase. We compare between the optic neuromyelitis and the multiple sclerosis, being based on the main ones characteristic clinical-epidemic that distinguishes these two pathologies, considered by many clinical variants of oneself illness(AU)
Assuntos
Humanos , Neuromielite Óptica/tratamento farmacológico , Neuromielite Óptica/epidemiologia , Neuromielite Óptica/patologia , Esclerose Múltipla/patologiaRESUMO
The optic neuromyelitis or syndrome of Devic is an inflammatory and autoimmune illness of the central nervous system. It is characterized by attacks of optic neuritis and myelitis, being able to produce blindness, great neurological disability and even the short term death. Until the moment an effective treatment doesn't exist, the therapy is centred in the treatment of the acute attacks, the medical prevention of the complications and the rehabilitation. This article is a revision of this not very common illness, considering that its prevalence in our country has gone in increase. We compare between the optic neuromyelitis and the multiple sclerosis, being based on the main ones characteristic clinical-epidemic that distinguishes these two pathologies, considered by many clinical variants of oneself illness.
Assuntos
Esclerose Múltipla/diagnóstico , Neuromielite Óptica , Doença Aguda , Adjuvantes Imunológicos/administração & dosagem , Adjuvantes Imunológicos/uso terapêutico , Administração Oral , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais Humanizados , Autoimunidade , Azatioprina/administração & dosagem , Azatioprina/uso terapêutico , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Acetato de Glatiramer , Humanos , Imunossupressores/administração & dosagem , Imunossupressores/uso terapêutico , Unidades de Terapia Intensiva , Interferon beta-1b , Interferon beta/administração & dosagem , Interferon beta/uso terapêutico , Masculino , Esclerose Múltipla/imunologia , Natalizumab , Neuromielite Óptica/diagnóstico , Neuromielite Óptica/epidemiologia , Neuromielite Óptica/imunologia , Neuromielite Óptica/prevenção & controle , Neuromielite Óptica/terapia , Peptídeos/administração & dosagem , Peptídeos/uso terapêutico , Plasmaferese , Prevalência , Proteínas Recombinantes/uso terapêutico , Fatores de TempoRESUMO
The Optic Neuromyelitis is an inflammatory and autoimmune illness of the central nervous system. Presently work is carried out a revision of the different mechanisms involved in the pathogenesis of the Optic Neuromyelitis, the paper of the eosinophils is analyzed, of the antibodies against own antigens and of the regulatory T cells in the illness. In the Optic Neuromyelitis is very important the humoral response, the illness exists it is characterized by the immunocomplex deposit, activation of the complement, production of antibodies against proteins of the myelin and eosinophils recruitment in the lesions. It also exists an increase of the expression of chemokines receptors like the CCR3, specific of TH2 cells; the illness is associate predominantly to a TH2 response.