Ultrasound, abdominal X-ray and dual-source CT in the diagnosis of colon tumor mechanical obstruction / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the value of ultrasound, abdominal X-ray, and dual-source CT (DSCT) in the diagnosis of colon tumor obstruction.</p><p><b>METHODS</b>A retrospective analysis was conducted among 45 patients who were admitted to our department between October 2010 and August 2011 for abdominal pain. All the patients underwent ultrasound, abdominal X-ray and DSCT examinations and subsequent surgical interventions, which confirmed the diagnosis of colon tumor obstruction.</p><p><b>RESULTS</b>DSCT diagnosis was obviously more efficient than ultrasound and X-ray in detecting colon obstruction by neoplasms, and could better predict the position of the obstruction. Complete information of the vessels in the surgical field could be obtained by DSCT imaging three-dimensional reconstruction.</p><p><b>CONCLUSIONS</b>Compared with ultrasound and X-ray, DSCT is more effective in the diagnosis of colon tumor obstruction by acquiring more thorough information by imaging reconstruction and should be considered for a rapid and accurate diagnosis.</p>

Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer / 南方医科大学学报

<p><b>OBJECTIVE</b>To explore the relationship between hypoxia-inducible factor-1α (HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.</p><p><b>METHODS</b>HIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.</p><p><b>RESULTS</b>Seventeen patients with colorectal cancer showed positivity for HIF-1α mRNA, showing a significantly higher positivity rate (42.5%) than the healthy subjects (P<0.05). The expression of HIF-1α mRNA is closely related to the staging of colorectal cancer (CRC).</p><p><b>CONCLUSION</b>HIF-1α mRNA may serve as a potential marker in the detection of metastasis of colorectal cancer.</p>

Application of intraoperative colon irrigation in primary resection and anastomosis of left colorectal cancer with intestinal obstruction / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the application of intraoperative irrigation of the colon in primary resection and anastomosis of left colorectal cancer with intestinal obstruction.</p><p><b>METHODS</b>The clinical data were analyzed in 58 patients with left colon rectal cancer and intestinal obstruction undergoing intraoperative irrigation of the colon for primary anastomosis, and the results were compared with 58 patients receiving conventional primary tumor resection.</p><p><b>RESULTS</b>The mean intraoperative blood loss or postoperative hospital stay was comparable between the two groups, but the patients undergoing colon irrigation had significantly delays in the recovery of bowel movement.</p><p><b>CONCLUSION</b>With strict control of the surgery indication, intraoperative colon irrigation can be safe and feasible in primary resection and anastomosis of left colorectal cancer with intestinal obstruction.</p>