RESUMO
OBJECTIVE: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS: Mice were treated with oral administration (p.o.) of ethanolic extract of TD (100, 200, and 300 mg/kg). Fluoxetine (FLX, a selective serotonin reuptake inhibitor) was used as a reference drug. Obsessive-compulsive behavior was evaluated using marble-burying apparatus. RESULTS: TD at doses of 100, 200, and 300 mg/kg dose-dependently inhibited the obsessive and compulsive behavior. The similar results were obtained from 5, 10, and 20 mg/kg of FLX. TD and FLX did not affect motor activity. CONCLUSION: The results indicated that TD and FLX produced similar inhibitory effects on marble-burying behavior.
RESUMO
Objective: To study the effect of ethanolic extract from Alpinia calcarata rhizomes on the serum lipid and leptin levels of rats with hyperlipidemia induced by high-fat diet. Methods: Male wistar rats were divided into six groups: normal, high-fat diet control (HFD) and ethanolic extract of Alpinia calcarata rhizomes (ACRE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10 mg/kg; p.o.) was used as a standard drug. Results: The results demonstrated that in HFD-induced hyperlipidemic rat, ACRE reduced rat weight gain, triglyceride (TG), total cholesterol levels (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total protein (TP) and leptin level (pg/mL). Conclusions: These encouraging findings suggest that ACRE has excellent pharmacological potential to prevent hyperlipidemia.
