How Do Deep Eutectic Solvents Form Porous Liquids? The Example of Methyltriphenylphosphonium Bromide: Glycerol and ZIF-8.

Porous liquids are new materials that provide permanent porosity in the liquid phase through the dispersion of nanoporous solid particles in a bulky solvent. Herein, we aim at understanding how new sustainable solvents such as deep eutectic solvent (DES) can be used to form porous stable suspensions for the capture of gases of interest for sustainable chemistry. The properties of an ionic DES, methyltriphenylphosphonium bromide/glycerol in a 1:3 molar composition, and its behavior at the interface with a metal-organic framework (MOF), ZIF-8, are here investigated by polarizable molecular dynamics simulations. The structural and dynamic properties of the DES are analyzed in the bulk liquid and in the interfacial regions with the MOF, namely, in the accessible cavities exposed at the surface. The porosity of the suspension is maintained, and it is caused not only by the Coulomb cohesive energy between cations and anions, which prevents the small anions from entering the pores, but also by the glycerol molecules not penetrating the small aperture of the ZIF-8 structure. This was further verified by simulating a system composed of glycerol and ZIF-8. Simulations with CO2 show its partition between the DES and the MOF, with higher concentrations registered in the MOF cavities.

Porous Ionic Liquids Go Green.

This Perspective points toward pathways to prepare porous ionic liquids using easily accessible materials, aiming for reduced environmental impact. We demonstrate that suspensions of porous solids are stable in eutectic mixtures, underscoring their potential for the preparation of porous ionic liquids. Porous ionic liquids retain the wide electrochemical window observed in their precursor pure ionic liquids, rendering them well-suited for green electrochemical reactions, particularly those involving gases whose solubility is enhanced in the porous suspensions. Moreover, their capacity as gas-rich media points to sustainable biomedical and pharmaceutical applications, provided nontoxic, biocompatible ionic liquids and porous solids are utilized.

Electrical and mechanical properties of self-supported hydroxypropyl methylcellulose-polyaniline conducting films.

The purpose of this work was to develop a simple method to produce self-supported films composed of hydroxypropyl methylcellulose (HPMC) and polyaniline (PANI) by the direct mixture of aqueous dispersions of both polymers with subsequent drying. The addition of HPMC, a cellulose derivative with an excellent film-forming capacity, was fundamental to overcoming the poor processability of PANI, which impairs its use in many technological applications. All films showed conductivity in the order of 10-2 to 10-3 S cm-1, which is in the range for metals or semiconductors. The typical electroactivity of PANI was also maintained in the hybrid films. The thermal stability and the mechanical properties of the pristine PANI were also improved with the addition of HPMC. Cellulose-containing conducting polymers can be considered a material of the future, with possible applications in several areas, such as smart wallpapers, e-papers, and sensors.

Application of empathy map on educational actions carried out by nursing professionals.

OBJECTIVE: to apply an empathy map to assess nursing professionals' needs, desires, frustrations and aspirations regarding educational actions. METHODS: a cross-sectional study, carried out in a hospital institution with 164 nursing professionals, who responded to the empathy map, which clarified their participation in institutional educational actions, which were collected from 2019 to 2020, and analyzed using descriptive statistics. RESULTS: when using the empathy map, educational actions focused on routines predominated, with the sharing of knowledge; promotion of improvements in care; agreement of commitment with proposed actions; insufficient compliance; little incentive to participate; dispersed guidelines among professionals; increased labor demand; and educational activity during the working day. CONCLUSIONS: the empathy map, applied as an instrument for assessing the institutional educational process, qualified as appropriate educational actions or opportunities to improve significant learning for professional nursing education.

Application of empathy map on educational actions carried out by nursing professionals / Aplicación del mapa de empatía en acciones educativas realizadas por profesionales de enfermería / Aplicação do mapa de empatia sobre as ações educativas realizadas pelos profissionais de enfermagem

ABSTRACT Objective: to apply an empathy map to assess nursing professionals' needs, desires, frustrations and aspirations regarding educational actions. Methods: a cross-sectional study, carried out in a hospital institution with 164 nursing professionals, who responded to the empathy map, which clarified their participation in institutional educational actions, which were collected from 2019 to 2020, and analyzed using descriptive statistics. Results: when using the empathy map, educational actions focused on routines predominated, with the sharing of knowledge; promotion of improvements in care; agreement of commitment with proposed actions; insufficient compliance; little incentive to participate; dispersed guidelines among professionals; increased labor demand; and educational activity during the working day. Conclusions: the empathy map, applied as an instrument for assessing the institutional educational process, qualified as appropriate educational actions or opportunities to improve significant learning for professional nursing education.

RESUMEN Objetivo: aplicar el mapa de empatía para evaluar las necesidades, deseos, frustraciones y aspiraciones de los profesionales de enfermería con respecto a las acciones educativas. Métodos: estudio transversal, realizado en una institución hospitalaria con 164 profesionales de enfermería, que respondieron al mapa de empatía, que clarificó su participación en las acciones educativas institucionales, que fueron recolectadas de 2019 a 2020, y analizadas mediante estadística descriptiva. Resultados: en el uso del mapa de empatía predominaron las acciones educativas enfocadas en las rutinas, con el intercambio de conocimientos; promover mejoras en la atención; acuerdo de compromiso con las acciones propuestas; adherencia insuficiente; poco incentivo para participar; pautas dispersas entre los profesionales; aumento de la demanda laboral; y la actividad educativa durante la jornada laboral. Conclusiones: el mapa de empatía, aplicado como instrumento de evaluación del proceso educativo institucional, calificado como acciones u oportunidades educativas adecuadas para mejorar los aprendizajes significativos para la formación profesional de enfermería.

RESUMO Objetivo: aplicar o mapa de empatia para avaliar as necessidades, desejos, frustrações e aspirações dos profissionais de enfermagem sobre as ações educativas. Métodos: estudo transversal, realizado em uma instituição hospitalar com 164 profissionais de enfermagem, que responderam o mapa de empatia, que elucidou sobre a participação em ações educativas institucionais, sendo esses colhidos de 2019 a 2020, e analisados pela estatística descritiva. Resultados: no uso do mapa de empatia, predominaram ações educativas voltadas às rotinas, com o compartilhamento de conhecimento; promoção de melhorias na assistência; pactuação de compromisso com as ações propostas; adesão insuficiente; pouco incentivo para participação; orientações dispersas entre os profissionais; demanda de trabalho aumentada; e atividade educativa durante a jornada de trabalho. Conclusões: o mapa de empatia, aplicado como instrumento de avaliação do processo educativo institucional, qualificou em ações educativas adequadas ou de oportunidade para melhoria de uma aprendizagem significativa para a formação profissional da enfermagem.

Salivary gland cancer in Southern Brazil: a prognostic study of 107 cases / Cáncer de glándula salival en el sur de Brasil: un estudio pronóstico de 107 casos

Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We per-formed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from thesouth of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features.Material and Methods: Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medicalrecords were examined to extract demographic, clinic, pathologic and follow-up information.Results: One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoidcarcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of caseswere classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentageof cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% asintermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineuralinvasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specificsurvival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis(p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diag-nosed with AdCC compared to MEC (p=0.02).Conclusions: The clinco-demographic and pathologic features identified as prognostic factors reveal the profile ofpatients at increased risk of recurrence and who would benefit from closer follow-up.(AU)

Photobiomodulation therapy modulates epigenetic events and NF-κB expression in oral epithelial wound healing.

The aim of this study was to evaluate the effect of photobiomodulation therapy (PBMT) on histone 3 acetylation (acH3) and NF-κB expression during oral ulcer healing. A total of 48 male Wistar rats were divided into control group (CG) and PBMT group (n = 24 each). Traumatic ulcers were created in the dorsum of the rats' tongue with a punch tool. Irradiation with InGaAlP laser, 660 nm, 40 mW, 0.04 cm2 spot size, 4 J/cm2, 4 s, and 0.16 J per spot was performed once a day in close contact for 10 consecutive days. CG received only daily handling. Rats were euthanized on days 3, 5, and 10 (n = 8) and were monitored daily to assess wound status. Immunohistochemical analysis for acH3 and NF-κB detection was performed. One thousand epithelial cells were counted, and mean acH3- and NF-κB-positive cells were calculated and compared between the groups. PBMT accelerated the repair of oral ulcers. On day 3, PBMT showed significantly higher means for acH3- and NF-κB-positive cells than CG. On day 5, no difference was observed between the groups concerning both markers. On day 10, PBMT presented lower acH3 and NF-κB means than the control group. We concluded that PBMT stimulates keratinocyte migration in the early stage of oral wound healing and keratinocyte differentiation at the final stage by modulating histone acetylation and NF-κB expression.

Avaliação de treinamento: uma proposta de trabalho / Training evaluation: a working proposal

É fato a importância de se analisar os resultados dos cursos e treinamentos que ocorrem, praticamente, todos os dias no âmbito da Secretaria Municipal de Saúde da cidade de São Paulo.A questão é: isto é feito? Como pode ser feito? Quais as orientações?São estas questões que se pretende trabalhar neste texto.Após algumas revisões bibliográficas que nos farão entender um pouco maissobre tipos de treinamentos, ou cursos, (que aqui chamarei de eventos ou açõesinstrucionais) que já são aplicados nesta grande Instituição que é a Secretaria Municipal de Saúde ou SMS, devemos refletir sobre um caminho que nos oriente de como podemos avaliá-los, sinalizar um fluxo que poderá ser aplicado em toda aSMS, apesar de suas múltiplas peculiaridades (AU)

Avaliação de treinamento: uma proposta de trabalho

É fato a importância de se analisar os resultados dos cursos e treinamentos que ocorrem, praticamente, todos os dias no âmbito da Secretaria Municipal de Saúde da cidade de São Paulo.A questão é: isto é feito? Como pode ser feito? Quais as orientações?São estas questões que se pretende trabalhar neste texto.Após algumas revisões bibliográficas que nos farão entender um pouco maissobre tipos de treinamentos, ou cursos, (que aqui chamarei de eventos ou açõesinstrucionais) que já são aplicados nesta grande Instituição que é a Secretaria Municipal de Saúde ou SMS, devemos refletir sobre um caminho que nos oriente de como podemos avaliá-los, sinalizar um fluxo que poderá ser aplicado em toda aSMS, apesar de suas múltiplas peculiaridades

Estudos retrospectivos no teste pós coital e espermocitograma / Retrospective studies of post coital test and sperm count

O presente estudo consta de 100 pacientes inférteis que engravidaram no período de 1980 a 1985; destas, 76 realizaram Teste Pós Coital (TPC). O espermocitograma foi realizado nos companheiros de 59 destas pacientes. O TPC foi realizado de 8 a 18 horas após coito e classificado em satisfatório, insatisfatório, ausente e negativo. O espermocitograma foi considerado normal com concentraçäo acima de 20 milhöes p/ml, 30% de movimentos direcionais e 30% de formas normais. Os resultados demonstram uma igualdade de gestaçöes entre TPC satisfatório e insatisfatório, o mesmo ocorrendo na vigência de um bom muco, independente dos resultados do TPC. No que se refere a análise do espermocitograma, entretanto, o prognóstico de gestaçöes se relaciona com mais evidência a concentraçäo, motilidade e formas anormais do que ao resultado do TPC (satisfatório ou insatisfatório). TPC negativo ou ausente sugere um prognóstico acentuadamente desfavorável porém näo em termos absolutos, duscute-se a oportunidade de nova classificaçäo para o TPC, devido aos resultados obtidos