RESUMO
This study assessed changes in serum levels of cytokines IFNgamma and IL-10 (biomarkers of inflammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothelial dysfunction) in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis.
Assuntos
Diabetes Mellitus Tipo 2/imunologia , Nefropatias Diabéticas/imunologia , Selectina E/sangue , Molécula 1 de Adesão Intercelular/sangue , Falência Renal Crônica/imunologia , Linfócitos T/imunologia , Adulto , Análise de Variância , Biomarcadores/sangue , Contagem de Células Sanguíneas , Estudos de Casos e Controles , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/complicações , Nefropatias Diabéticas/sangue , Nefropatias Diabéticas/complicações , Egito , Humanos , Inflamação , Interferon gama/sangue , Interleucina-10/sangue , Falência Renal Crônica/sangue , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Testes de Função Renal , Testes de Função Hepática , Pessoa de Meia-Idade , Diálise Renal , Estatísticas não ParamétricasRESUMO
This study assessed changes in serum levels of cytokines IFNgamma and IL-10 [biomarkers of inflammatory changes] and soluble biomarkers sICAM-1 and sE-selectin [biomarkers of endothelial dysfunction] in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy [DN] and end-stage renal disease [ESRD] compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis
