Lung cancer survival and deletion of GSTM1 and GSTT1 genes. A case-series from Spain.

AIMS AND BACKGROUND: Lung cancer has a high incidence, and only 15% of all cases are alive 5 years after the diagnosis. Identifying the role of the genes implicated in the success of chemotherapy agents is crucial to predict survival. The objective of the study was to assess the effect of GSTM1 and GSTT1 gene deletion on lung cancer survival. METHODS AND STUDY DESIGN: A consecutive sampling of lung cancer cases was performed in 1999-2000 at the University Hospital of Santiago de Compostela, Spain, and GSTM1 and GSTT1 genes were genotyped. The effect of GSTM1 and GSTT1 deletion on survival was analyzed with the logrank test and with Cox regression. RESULTS: A total of 132 individuals were included, and more than half of them had stage IV lung cancer at diagnosis. Survival was similar irrespective of the presence or absence of the GSTM1 gene, whereas those with deleted GSTT1 had a significantly shorter survival. In multivariate Cox regression analysis, no significant effect was observed for the deletion of any of the genes, although there was a tendency towards a worse survival for those with deletion of GSTT1. The main limitation was that stage at diagnosis could not be considered in the analysis since most of the patients were diagnosed at stage IV. CONCLUSIONS: GSTT1 appears to influence lung cancer survival whereas GSTM1 seems to have no effect.

Resultados de la aplicación de la técnica SNOLL versus tumorectomía guiada con arpón en el cáncer de mama / Results of the SNOLL technique versus wire guided lumpectomy in the treatment of breast cancer

Objetivo. Comparar los resultados de la aplicación de la técnica SNOLL frente a la tumorectomía guiada con arpón en el tratamiento del cáncer de mama. Material y método. Estudio retrospectivo realizado en la Unidad de Patología Mamaria del Complejo Hospitalario Universitario de Vigo desde mayo del 2010 y hasta febrero del 2012. Resultados. Se estudió a 73 pacientes; 34 mujeres fueron intervenidas mediante la técnica del SNOLL y en 39 la exéresis tumoral fue guiada con arpón. El tipo histológico más frecuente en ambos grupos, fue el carcinoma ductal infiltrante (el 94 y el 64,1%, respectivamente; p = 0,005). Del total de casos en que el tumor contactó con los bordes quirúrgicos en el estudio intraoperatorio, el 55,3% de ellos fueron casos del grupo SNOLL y el 44,7% del grupo arpón. La tasa de ampliación de los márgenes de la pieza en el mismo acto quirúrgico fue mayor en el grupo SNOLL (p = 0,160). La tasa de reintervención para la ampliación de los márgenes de la pieza quirúrgica en un segundo tiempo fue del 0% en el grupo SNOLL y del 13% en el grupo del arpón(p = 0,57). En el grupo SNOLL, el margen libre de enfermedad en la pieza final fue de media de 7,21 mm y de 4,66 mm en el grupo arpón (p = 0,01). Conclusiones. Ambas técnicas son comparables en cuanto a la tasa de reescisiones. El SNOLL permite obtener un mayor margen de seguridad (AU)

Objective: To compare the results of the SNOLL technique with those of wire-guided lumpectomy in the treatment of breast cancer. Material and methods: A retrospective study conducted in the Breast Pathology Unit of the Vigo University Hospital from May 2010 to February 2012. Results: We studied 73 patients. The SNOLL technique was used in 34 women and wire-guided lumpectomy in 39. In both groups, the most common histological type was infiltrating ductal carcinoma (94% and 64.1%, respectively, P=.005). In the intraoperative study, 55.3% of tumors in the SNOLL group and 44.7% of those in the wire-guided group were found to touch the surgical margin. The rate of margin extension in the same intervention was higher in the SNOLL group (P=.160). The reoperation rate for margin extension was 0% in the SNOLL group and 13% in the wire-guided group (P=.57). In the final surgical specimen, the mean disease-free margin was 7.21 mm in the SNOLL group and 4.66 mm in the wire-guided group (P=.01). Conclusions: The re-excision rate was similar in the two groups. The SNOLL technique allows a greater margin of safety (AU)