Interleukin (IL) -1 ß, IL-6 and tumor necrosis factor in patients with seasonal flu.

OBJECTIVE: The role of tumor necrosis factor (TNF), interleukin (IL)-1ß and IL-6 in the pathogenicity of seasonal flu is unknown. METHODS: We analyzed the profiles of these cytokines in 77 flu patients and 17 controls with non-flu respiratory infection, using molecular biology techniques (real-time polymerase chain reaction). RESULTS: Flu patients had lower monocyte counts (p=0.029) and a slightly lower median level of IL-6 (P=0.05) than the control group. Twenty-four flu patients (31.2%) had pneumonia; this group had higher C-reactive proteins (p=0.01) and monocyte levels (p=0.009). Pro-inflammatory cytokines levels did not rise in patients with pneumonia complicating seasonal influenza. CONCLUSIONS: IL-6 levels were lower in adults with influenza.

Síndrome de POEMS incompleto asociado a enfermedad de Castleman multicéntrica y amiloidosis / Incomplete POEMS syndrome with multicentric Castleman’s disease and amyloidosis

La enfermedad de Castleman (EC) es un trastorno linfoproliferativo atípico de causa desconocida, caracterizado por crecimiento ganglionar hiperplásico no clonal. Actualmente se reconocen dos formas de presentación clínica, una localizada y otra multicéntrica, y cuatro variantes histopatológicas. Clínicamente se caracteriza por linfadenopatías generalizadas, hepatoesplenomegalia, fiebre y sudoración nocturnas. La EC puede presentar pancitopenia grave y fallo multiorgánico, evolucionar a linfoma y, en algunas ocasiones, asociarse a síndromes paraneoplásicos como el síndrome de POEMS. Las asociaciones de estas dos entidades han sido ampliamente descritas en la literatura actual, aunque su asociación con amiloidosis es menos frecuente y descrita como casos clínicos aislados. Presentamos un caso clínico con esta triple asociación: EC, POEMS y amiloidosis (AU)

Castleman’s disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. CD may present severe pancytopenia, multi-organ failure, lymphoma evolution and it can sometimes be associated with paraneoplastic syndromes such as POEMS syndrome. Associations of these two entities have been widely described in the current literature, although its less common association with amyloidosis is described as isolated clinical cases. We report a case with this triple association: EC, POEMS and amyloidosis (AU)

[Incomplete POEMS syndrome with multicentric Castleman's disease]. / Síndrome de POEMS incompleto asociado a enfermedad de Castleman multicéntrica y amiloidosis.

Castleman's disease (CD) is an atypical lymphoproliferative disorder of unknown cause, characterized by non-clonal nodal hyperplastic growth. Two forms of clinical presentation are currently recognized, one localized and the other multicentric, and four histopathologic variants. It is characterized by generalized lymphadenopathy, hepatosplenomegaly, fever and night sweats. CD may present severe pancytopenia, multi-organ failure, lymphoma evolution and it can sometimes be associated with paraneoplastic syndromes such as POEMS syndrome. Associations of these two entities have been widely described in the current literature, although its less common association with amyloidosis is described as isolated clinical cases. We report a case with this triple association: EC, POEMS and amyloidosis.