RESUMO
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease, and may progress to cirrhosis and associated with complications of end-stage liver disease. The immunological characteristic of PBC is the presence of anti-mitochondrial autoantibodies (AMAs), and some anti-nuclear antibodies (ANAs) have high specificity for the diagnosis of PBC. In recent years, it has been found that anti-gp210, anti-sp100 and anti-centromere antibodies are correlated with the severity of PBC, treatment response to ursodeoxycholic acid (UDCA) and poor prognosis. However, correlation between AMAs and disease progression of PBC is still in controversial. This article reviewed the progress in research on the influence of autoantibodies on biochemical response and prognosis of PBC.
RESUMO
An HPLC method for the quantitative determination of icariin and an UV method for the determination of flavonoids in Co-Wuzi granule Preparation were developed. Results showed that the amount of icariin was 0. 050%, RSD=0. 72%, and the amount of flavonoids was 0. 120%, RSD=3. 8%. The HPLC method was very effective in the separation of active principles,suitable for the quantitative determination of single component in compounded TCM preparations,while the UV method may be used for the identification of active parts of TCM preparations.
