RESUMO
In experimental works on guinea-pigs, it is the parenteral administration of drugs which offers most commodity and security. The use of aureomycin by this route has certain disadvantages and inconveniencies which do not recommend it. The adaptation made by the authors, however, of the antibiotic which was originally destined for enteral application, permitted the perfect utilization of the parenteral route, by eliminating undesirable reactions. By applying a single or fractioned dose they were able to show the preventive or curative efficacy of aureomycin, after adaptation to parenteral use on experimental spotted fever in guinea-pigs which had been infected with rickettsias isolated in São Paulo.
Nos trabalhos experimentais em que se utilizam cobaias, a administração parenteral dos medicamentos é a via que mais comodidade e segurança oferece. O emprego da aureomicina, por essa via, acarreta certos prejuízos e inconvenientes que a contraindicam. Entretanto, o antibiótico destinado, originariamente, à via enteral, após processo de adaptação feito pelos autores, permitiu tornar a via parenteral perfeitamente utilizável, afastando reações indesejáveis. Empregando dose única ou dose fracionada, foi-lhes possível, assim, mostrar a eficiência preventiva ou curativa da aureomicina adaptada ao uso parenteral, sobre a febre maculosa experimental em cobaias, infectadas com rickettsias isoladas em São Paulo.
RESUMO
In experimental works on guinea-pigs, it is the parenteral administration of drugs which offers most commodity and security. The use of aureomycin by this route has certain disadvantages and inconveniencies which do not recommend it. The adaptation made by the authors, however, of the antibiotic which was originally destined for enteral application, permitted the perfect utilization of the parenteral route, by eliminating undesirable reactions. By applying a single or fractioned dose they were able to show the preventive or curative efficacy of aureomycin, after adaptation to parenteral use on experimental spotted fever in guinea-pigs which had been infected with rickettsias isolated in São Paulo.
Nos trabalhos experimentais em que se utilizam cobaias, a administração parenteral dos medicamentos é a via que mais comodidade e segurança oferece. O emprego da aureomicina, por essa via, acarreta certos prejuízos e inconvenientes que a contraindicam. Entretanto, o antibiótico destinado, originariamente, à via enteral, após processo de adaptação feito pelos autores, permitiu tornar a via parenteral perfeitamente utilizável, afastando reações indesejáveis. Empregando dose única ou dose fracionada, foi-lhes possível, assim, mostrar a eficiência preventiva ou curativa da aureomicina adaptada ao uso parenteral, sobre a febre maculosa experimental em cobaias, infectadas com rickettsias isoladas em São Paulo.
RESUMO
Having verified by a great number of cases of Rocky Mountain Spotted Fever that the treatment can only be of benefit to a limited number of patients, because of the fact that it is only started rather late, the authors think that the therapeutic problem rests on the rapidity with which the disease has to be fought. In fact, the patients enter the hospital, in general, on the ninth day of the disease, and the death occurs generally on the second week of the disease. Thus they advise the association of the parenteral to the enteral route in the administration of the antibiotics. The inconveniences caused by the injection of Aureomycin, such as: irritation, intense local pain, inflammation and necrosis were removed by the method introduced by J. J. Macedo, O. Haberbeck Brandão and E. Lemos Monteiro who succeeded in using the antibiotic produced for oral administration as subcutaneous injections without the occurrence of the mentioned reactions. In a series of experiences carried on by the authors in the Instituto Butantan, São Paulo, Brazil, they verified that the guinea-pigs infected by Dermacentroxenus Rickettsi, when receiving simultaneously the injection of a solution of purified Aureomycin, in a sufficiently large dosis, were not infected; if the dosis were insufficient, the disease was delayed in its development. In experimentally infected animals, the Aureomycin, injected s
Em colaboração com LACAZ (1948-1949), publicamos um trabalho sôbre Blastomicose tipo Jorge Lobo, considerada, hoje em dia, como forma queloideana da blastomicose sul-americana. Nessa publicação, anotamos 6 casos da referida micose, comprovados histopatológicamente. Estava já no prelo o trabalho, quando soubemos da ocorrência de um novo, em São Paulo, observado por CERRUTI e ZAMITH (1948). Elevava-se, assim, a 7 o número casos conhecidos no Brasil e comprovados Histopatológicamente.
RESUMO
Having verified by a great number of cases of Rocky Mountain Spotted Fever that the treatment can only be of benefit to a limited number of patients, because of the fact that it is only started rather late, the authors think that the therapeutic problem rests on the rapidity with which the disease has to be fought. In fact, the patients enter the hospital, in general, on the ninth day of the disease, and the death occurs generally on the second week of the disease. Thus they advise the association of the parenteral to the enteral route in the administration of the antibiotics. The inconveniences caused by the injection of Aureomycin, such as: irritation, intense local pain, inflammation and necrosis were removed by the method introduced by J. J. Macedo, O. Haberbeck Brandão and E. Lemos Monteiro who succeeded in using the antibiotic produced for oral administration as subcutaneous injections without the occurrence of the mentioned reactions. In a series of experiences carried on by the authors in the Instituto Butantan, São Paulo, Brazil, they verified that the guinea-pigs infected by Dermacentroxenus Rickettsi, when receiving simultaneously the injection of a solution of purified Aureomycin, in a sufficiently large dosis, were not infected; if the dosis were insufficient, the disease was delayed in its development. In experimentally infected animals, the Aureomycin, injected s
Em colaboração com LACAZ (1948-1949), publicamos um trabalho sôbre Blastomicose tipo Jorge Lobo, considerada, hoje em dia, como forma queloideana da blastomicose sul-americana. Nessa publicação, anotamos 6 casos da referida micose, comprovados histopatológicamente. Estava já no prelo o trabalho, quando soubemos da ocorrência de um novo, em São Paulo, observado por CERRUTI e ZAMITH (1948). Elevava-se, assim, a 7 o número casos conhecidos no Brasil e comprovados Histopatológicamente.