RESUMO
Objective: This study investigates the extent of resection, duration of surgery, intraoperative blood loss, and postoperative complications in patients with high-grade glioma who received surgery with or without sodium fluorescein guidance. Methods: A single-center retrospective cohort study was conducted on 112 patients who visited our department and underwent surgery between July 2017 and June 2022, with 61 in the fluorescein group and 51 in the non-fluorescein group. Baseline characteristics, intraoperative blood loss, surgery duration, resection extent, and postoperative complications were documented. Results: The duration of surgery was significantly shorter in the fluorescein group than in the non-fluorescein group (P = 0.022), especially in patients with tumors in the occipital lobes (P = 0.013). More critically, the gross total resection (GTR) rate was significantly higher in the fluorescein group than in the non-fluorescein group (45.9% vs. 19.6%, P = 0.003). The postoperative residual tumor volume (PRTV) was also significantly lower in the fluorescein group than in the non-fluorescein group (0.40 [0.12-7.11] cm3 vs. 4.76 [0.44-11.00] cm3, P = 0.020). Particularly in patients with tumors located in the temporal and occipital lobes (temporal, GTR 47.1% vs. 8.3%, P = 0.026; PRTV 0.23 [0.12-8.97] cm3 vs. 8.35 [4.05-20.59] cm3, P = 0.027; occipital, GTR 75.0% vs. 0.0%, P = 0.005; PRTV 0.15 [0.13-1.50] cm3 vs. 6.58 [3.70-18.79] cm3, P = 0.005). However, the two groups had no significant difference in intraoperative blood loss (P = 0.407) or postoperative complications (P = 0.481). Conclusions: Fluorescein-guided resection of high-grade gliomas using a special operating microscope is a feasible, safe, and convenient technique that significantly improves GTR rates and reduces postoperative residual tumor volume when compared to conventional white light surgery without fluorescein guidance. This technique is particularly advantageous for patients with tumors located in non-verbal, sensory, motor, and cognitive areas such as the temporal and occipital lobes, and does not increase the incidence of postoperative complications.
RESUMO
in this paper we report the blood cobalt, methemoglobin and blood cyanide concentration-time equations and related parameters of pharmacokinetics after abministra-tion of sodium cobaltinitrite(18.6mg/kg)or potassium cyanide(3mg/kg)in dogs.It was found that 10% dimethyl sulfoxide used as a solvent, as compared with water, accelerated sodium cobaltinitrite absorption by intramuscular administration.The half absorption time was reduced from 14.5 min to 5.5 min, the time of maximum concentration of blood cobalt reduced from 1.11 h to 0.56 h, and the maximum conce-tration of blood cobalt raised from 2.71?g/ml to 3.35?g/ml.There was a significant difference of blood cobalt concentrasions between 10-60 and 120 min after intramuscular administration.
RESUMO
This paper reports the antagonistic effect of sodium cobaltinitrite by intramus-cular injection on cyanide intoxication. The sodium cobaltinitrite (10%) dime-thylsulfoxide solution was administrated intramuscularly when convulsion appeared in dogs 5-10 min after intramuscular injection of potassium cyanide(1-2.5LD) or 15s after inhalation of hydrocyanic acid (2LD50). The animal survival rate was 20/22 and 8/10, respectively. The cats intoxicated by lethal dose of hydrocyanic acidinhalation were given sodium cobaltinitrite intramuscularly, and a good therapeutic effect was also obtained.This study provides an experiment basis in search of an antagonist of cyanide, which takes effect rapidly, is administrated conveniently and is suitable rescue in the field, with a convenient administrating means.
