A Case of Cowden Syndrome / 대한피부과학회지

Cowden syndrome is a rare autosomal dominant disorder characterized by mucocutaneous alterations including multiple facial trichilemmomas, oral mucosal papillomatosis, and acral keratoses. Extracutaneous lesions include polyposis of the gastrointestinal tract, and other multiple hamartoma of the internal organs. A 39 year-old man presented with multiple verruca-like papules and lichenified patches on the face, one year ago. He had been treated for atopic dermatitis for more than 10 years. Although he had been treated in accordance with atopic dermatitis for 1 year, his skin lesions had not improved, so a skin biopsy was performed. The skin biopsy specimen revealed the typical finding of trichilemmoma. Colonoscopy diagnosed diffuse colorectal polyposis. The clinical and hisopathologic findings were consistent with Cowden syndrome. We, herein, report a case of Cowden syndrome with atopic dermatitis.

A Case of Acrosyringeal Nevus / 대한피부과학회지

Acrosyringeal nevus is a rare condition, which includes proliferation of acrosyringeal keratinocytes, and the proliferation extends from the undersurface of the epidermis down into the dermis as thin anastomosing cords. It is, however, controversial whether acrosyringeal nevus is the same lesion as eccrine syringofibroadenoma, because of several clinicopathological differences. We report a case of benign tumor, consisting of eccrine structures, which occurred in a 60-year-old man. The histopathological features of the excisional biopsy were consistent with acrosyringeal nevus.