RESUMO
CASE REPORT: A 4-month old girl affected by gastric duplication discovered as a palpable abdominal mass displacing the spleen and left kidney. During laparotomy, a yellowish secretion is aspirated and the gastric duplication is excised together with the common muscular Wall of the greater curvature of the stomach. Also excised, a tubular structure starting from the inferior pole of the malformation, and communicating with it, passing superior to the head of the pancreas and the second portion of the duodenum, followed by a posterior course before inserting into the right cruz of the diaphragm. The histology of the tubular formation was compatible with esophagus. CONCLUSION: This type of duplication has not been reported in the literature and reinforces the theory that these malformations could be secondary to genetic transcription errors, in the differentiation of the endoderm of the primitive digestive tract and the notochord.
CASO CLINICO: Niña de 4 meses, afecta de una duplicidad gástrica, descubierta como masa abdominal palpable y que desplazaba el bazo y el riñón izquierdo. Mediante laparotomía, se observa una duplicidad gástrica y, tras aspirar una secreción amarillenta, se realiza su exéresis junto con la pared muscular común con la curvatura mayor del estómago y una estructura tubular que, partiendo del polo inferior de la malformación y comunicada con ella, pasaba por encima de la cabeza del páncreas y de la segunda porción duodenal, siguiendo luego un curso posterior hasta insertarse en la base del pilar diafragmático derecho. La histología de esta formación tubular fue compatible con el esófago. CONCLUSIONES: Este tipo de duplicidad no la hemos visto referida en la literatura y refuerza la teoría de que estas malformaciones pudieran ser secundarias a errores de transcripción genéticas de información en la diferenciación del endodermo del tubo digestivo primitivo y de la notocorda.
Assuntos
Esôfago/anormalidades , Laparotomia/métodos , Estômago/anormalidades , Esôfago/cirurgia , Feminino , Humanos , Lactente , Estômago/cirurgiaRESUMO
BACKGROUND & AIMS: The partial resection of the intestine could affect the liver through alteration in nutrient absorption, loss of the bile acids via the enterohepatic circulation, alterations in the hepato-duodenobilio-pancreatic hormonal complex as well as a bacterial translocation. All these factors could sum up and induce changes in the tissue composition and in hepatic histomorphology. The aim of this experimental study is to acquire a profound knowledge of these hepatic alterations after the partial intestinal resection. M & M: 26 Dunkin Hartley guinea pigs were used: Group A with only jejunum resection, Group B with only ileum resection, and Group CtrG, the control group. They were monitored for 21 days. At the end, blood samples were taken for serum biochemical analysis. Samples of hepatic tissue were taken for histomorphological optical study. All the rest liver was homogenize and the fat liver composition was analysed (total fat, lipid fractions, phospholipids fractions and fatty acids of the liver). RESULTS: There was a significant decrease in serum cholesterol in both GA & GB. There was also a decrease of the total fat/g liver tissue, without changes in the phospholipids fraction and decreases in the C18-2/C18-3 and w6/w3 ratios. There was a minimal macrosteatosis and reduction of the number of mitochondries in GB. CONCLUSIONS: the partial intestinal resection, specially ileum resections, looks like influence the structural fat liver composition. However, these changes could be compensated for by the liver and oral nutrition. These findings help us to improve the liver-intestinal relationships.
Assuntos
Gastroscopia/efeitos adversos , Intestinos/fisiologia , Lipídeos/análise , Fígado/anatomia & histologia , Fígado/química , Animais , Análise Química do Sangue , Ácidos Graxos/análise , Fígado Gorduroso/etiologia , Fígado Gorduroso/patologia , Cobaias , Íleo/fisiologia , Absorção Intestinal , Intestinos/cirurgia , Jejuno/fisiologia , Mitocôndrias Hepáticas/patologia , Fosfolipídeos/análiseRESUMO
The systemic inflammatory response syndrome (SRIS) seems to be due to the activation of the toll-like receptors, specific of the inflammatory response cells, through concrete cytosolic signals which lead to a cascade of reactions acting cytokins, growing factors and others inflammatory mediators. This kind of work revewes and discusses several classifications of animals models to study the SRIS, and propose to divide these models according to concrete goals, which can be the following ones: (1) To study innate and adaptative receptors of regulatory gens in the SRIS. (2) To study signals receptors (cytokines and growing factors). (3) To study the answer to signals. (4) To study treatments through specifics antinflammatory blockage. (5) Specific models of sepsis. (6) Others inducing models of SRIS. (7) Others therapeutical models. -Antinflammatories. -Antiacoagulans: Coagulations inhibition in human assays. Phase II Anticoagulans: Antitrombine III, PCA and TFPI. -Antibiotics. -Replacing Volume Treatments. -Surgical Treatments. As to the animals models to study Parenteral Nutrition, we could make the next classifications and sum it up: (1) Animal models to study the parenteral via of administration. (2) Models to study viability, absorption and local tolerance of the administration via. (3) Study models for complications. (4) Animal models to study pharmacodynamic, metabolization and to investigate the tolerance of new molecules or substrates.
Assuntos
Modelos Animais de Doenças , Nutrição Parenteral , Síndrome de Resposta Inflamatória Sistêmica , Animais , Humanos , Nutrição Parenteral/instrumentação , Síndrome de Resposta Inflamatória Sistêmica/imunologiaRESUMO
The hydatidosis is a frequent zoonosis in Spain, but isolated location in pancreas and their onset as acute abdomen is excepcional. We present a boy 14 years old, with abdominal pain and low-grade fever since 1 month. Hemogram shows eosinophilia, and echography an anechoic mass in tail of pancreas beside of free peritoneal liquid. At surgery procedure: a broken hydatid cyst is verified, surrounded of tissues inflammatory reaction that evolved to pancreatic fistula. The differents forms from clinical presentation of the pancreatic hydatid cyst, as well as the complications related to their location are analyzed.
Assuntos
Abdome Agudo/parasitologia , Equinococose/complicações , Abdome Agudo/diagnóstico por imagem , Adolescente , Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Terapia Combinada , Equinococose/diagnóstico por imagem , Equinococose/terapia , Humanos , Masculino , Pancreatopatias/complicações , Pancreatopatias/diagnóstico por imagem , Pancreatopatias/terapia , Tomografia Computadorizada por Raios X , UltrassonografiaRESUMO
La hidatidosis es una zoonosis frecuente en España; sin embargo, la localización única en páncreas y su aparición como abdomen agudo es excepcional. Presentamos un varón de 14 años de edad, con historia de dolor abdominal y febrícula de 1 mes de evolución. En el hemograma se observa una eosinofilia y en la ecografía se comprueba la existencia de una masa anecoica en cola de páncreas, además de líquido libre. Durante la intervención, se comprueba la existencia de un quiste hidatídico (QH) roto, con reacción inflamatoria de los tejidos de alrededor, que posteriormente hizo un pseudoquiste pancreático como consecuencia de una fístula pancreática. Se analizan las diferentes formas de presentación clínica de los QH pancreáticos, así como las complicaciones originadas por su localización (AU)
The hydatidosis is a frequent zoonosis in Spain, but isolated location in pancreas and their onset as acute abdomen is excepcional. We present a boy 14 years old, with abdominal pain and low-grade fever since 1 month. Hemogram shows eosinophilia, and echography an anechoic mass in tail of pancreas beside of free peritoneal liquid. At surgery procedure: a broken hydatid cyst is verified, surrounded of tissues inflammatory reaction that evolved to pancreatic fistula. The differents forms from clinical presentation of the pancreatic hydatid cyst, as well as the complications related to their location are analysed (AU)
Assuntos
Masculino , Adulto , Humanos , Abdome Agudo/parasitologia , Equinococose/complicações , Pancreatopatias/complicações , Abdome Agudo , Abdome Agudo , Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Terapia Combinada , Equinococose/terapia , Equinococose , Pancreatopatias/terapia , Pancreatopatias , Tomografia Computadorizada por Raios XRESUMO
The epidermoid cysts are frequent during childhood, however mouth floor location are very unusual, because of their more difficult diagnosis and therapeutic approach. We present a 5 years old male, symptoms free until a week before, when his parents noticed a well defined mass in the mouth floor. A physical examination leaded to the diagnosis of possible epidermoid cyst. The tumor was excised through an introral approach. A review of different diagnostic means and surgical management are undertaken.
Assuntos
Cisto Epidérmico/cirurgia , Doenças da Boca/cirurgia , Pré-Escolar , Humanos , Masculino , Soalho Bucal/cirurgiaRESUMO
The photopheresis (ECP) is a therapeutic approach based on the biological effect of psoralen and ultraviolet light A on mononuclear cells collected by apheresis, and reinfused into the patient. In 1988, the treatment was the first FDA-approved selective immunotherapy for any type of cancer. Convincing data taken from over 160 centers in Europe and the U.S.A. over the past few years have documented that ECP is associated with a very low side-effect profile. Evidence shows that this therapy prolongs the mean survival, and also induces 50-75% response rates in patients with advanced cutaneous T-cell lymphoma. In addition, more and more reports indicate that photopheresis is a potent agent in the therapy of solid organ transplant rejection, graft versus host disease, scleroderma, and other autoimmune diseases resistant to conventional therapy. The mechanism of this treatment is likely due to the induction of cell-mediated anticlonotypic immune response against pathogenic clones of T lymphocytes.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Doenças Autoimunes/terapia , Fotoferese/métodos , Linfócitos T/imunologia , Doenças Autoimunes/imunologia , Humanos , Imunoterapia/métodos , Linfócitos T/patologiaRESUMO
Los quistes epidermoides son una patología frecuente en la infancia, sin embargo, su localización sublingual es excepcional, lo cual origina dificultades diagnósticas y terapéuticas. Presentamos un varón, de 5 años de edad, asintomático, que desde una semana antes, los padres le han observado una tumoración situada en el suelo de la boca, bien delimitada y mediante una exploración detenida se sospecha la existencia de un posible quiste que se extrae mediante un abordaje oral, confirmando el estudio histológico el diagnostico de quiste epidermoide. Se analiza los diferentes medios diagnósticos y las posibles vías de abordaje quirúrgico utilizadas (AU)
Assuntos
Pré-Escolar , Masculino , Humanos , Doenças da Boca , Soalho Bucal , Cisto EpidérmicoRESUMO
The livers of healthy individuals, where different products are synthesized and metabolized, carries out a series of complex metabolic functions. Furthermore, there is an important relationship with the digestive apparatus, such as for the secretion, excretion and re-circulation of bile, and also with the various hormonal systems or the bacterial microflora of the intestine. When artificial feeding (AF) is used, this may lead to changes in the functionality and structure of the liver, which may or may not be reversible depending on the base situation of the patient and the type of AF administered. This would be enough to bring about a series of changes followed by adaptive phenomena in the liver itself. The degree of hepatic damage triggered by artificial feeding will depend on the interaction of all these elements and the specific characteristics of each case.
Assuntos
Nutrição Enteral , Hepatopatias , Nutrição Parenteral , Nutrição Enteral/efeitos adversos , Humanos , Hepatopatias/epidemiologia , Hepatopatias/etiologia , Hepatopatias/patologia , Hepatopatias/terapia , Nutrição Parenteral/efeitos adversos , Fatores de RiscoRESUMO
The main localization of hydatic cysts (HC) in mediastinum is exceptional. We present the case of a 12 year-old boy who had habitual contact with dogs. He had pain in the right hemithorax and back together with low-grade fever. In the X-rays of the thorax a right retrocardiac image shows an occupied costodiaphragmatic sinus. The CT of the thorax shows a bilateral pleural effusion and a mass measuring 10 x 7.5 x 5 cm in the middle mediastinum. After admission, a new X-ray of the thorax revealed an increase in the right pleural discharge, for which reason an urgent thoracotomy was performed checking for the existence of a mediastinum HC with possible membrane fissures. The HC was removed. The only treatment of HC in mediastinum is surgical, an urgent thoracotomy being necessary whenever a possible rupture is suspected in order to avoid a possible anaphylatic reaction or growth pleural cavity.
Assuntos
Equinococose/cirurgia , Doenças do Mediastino/cirurgia , Criança , Equinococose/diagnóstico , Humanos , Masculino , Doenças do Mediastino/diagnósticoRESUMO
La localización primaria de los quistes hidatídicos (QH) en mediastino es excepcional. Presentamos un varón, de 12 años, con contacto habitual con perros, que acude por presentar dolor en hemitóraz derecho y espalda junto con febrícula. En las Rx de tórax se aprecia una imagen retrocardíaca derecha con ocupación de seno costodiafragmático. En la TAC de tórax aparece un derrame pleural bilateral y una masa de 10 x 7,5 x 5 cm en mediastino medio. Tras su ingreso, una nueva radiografía de tórax revela un aumento del derrame pleural derecho, por lo que se realiza una toracotomía de urgencia, comprobándose la existencia de un QH mediastínico con posibles fisuras de la membrana, procediendo a su extirpación. El tratamiento de los QH en mediastino es quirúrgico, debiendo realizar una toracotomía de urgencia, siempre que se sospeche una rotura, para evitar una posible reacción anafiláctica o una siembra en cavidad pleural (AU)
Assuntos
Criança , Masculino , Humanos , Equinococose , Doenças do MediastinoRESUMO
UNLABELLED: Lymphangiomas are very common neoplasms in infancy. However, a retroperitoneal location is seldom observed. We present the case of a male with a history of chronic recurrent pain over a period of several years. An X-ray showed a calcic density in the left upper abdominal quadrant; the histological study revealed it to be a mixoid cystic lymphangioma. Clinical presentation varies greatly from an asymptomatic mass to serious complications. In order to correctly diagnose of these neoplasms it is essential to carry on ultra sound and CT examination although a simple abdominal X-ray may show calcifications as the one presented here. Treatment is always surgical and a complete extirpation should be performed, unless vital structures were are involved. Treatment with laser, fibrin and sclerotherapy have also been used. CONCLUSION: In spite of being benign neoplasms we believe they should be removed to confirm diagnosis and avoid possible complications.
Assuntos
Linfangioma Cístico/diagnóstico , Neoplasias Retroperitoneais/diagnóstico , Criança , Humanos , MasculinoRESUMO
The haemangiomas are benign vascular tumors of frequent apparition in infant, but not very much described in penis glans in the literature. We present a case with location in penis glans, in a short age male, that it was treated through conventional surgery with good results. We accomplish a review of this pathology and we make reference to the different ways of treatment today.
Assuntos
Hemangioma , Neoplasias Penianas , Criança , Hemangioma/diagnóstico , Hemangioma/cirurgia , Humanos , Masculino , Neoplasias Penianas/diagnóstico , Neoplasias Penianas/cirurgiaRESUMO
Although vesical extrophy is a well-known anomaly, the variants of vesical extrophy are exceptional. We present the case of a newborn child, who upon exploration, revealed a defect of closure in the infra-umbilical abdominal wall through which vesical mucous membrane protruded. A probe introduced into the urethra appeared externally at the place of the infraumbilical defect. Following the diagnosis of superior vesical fissure, resection of the protruding vesical mucous membrane and closure were carried out. The authors reviewed the bibliography published in order to study the different kinds of variants of vesical extrophy and the associated congenital anomalies. Although these children are usually continent, a urodynamic study and a VCU are recommended in order to discard the existence of a post closure-uretheral-vesical reflux of the umbilical defect.
Assuntos
Bexiga Urinária/anormalidades , Bexiga Urinária/cirurgia , Feminino , Humanos , Recém-NascidoAssuntos
Acetiltransferases/metabolismo , Antineoplásicos/uso terapêutico , Carcinoma Papilar/tratamento farmacológico , Sulfassalazina/uso terapêutico , Neoplasias da Bexiga Urinária/tratamento farmacológico , Acetiltransferases/genética , Carcinoma Papilar/enzimologia , Carcinoma Papilar/genética , Criança , Feminino , Humanos , Fenótipo , Neoplasias da Bexiga Urinária/enzimologia , Neoplasias da Bexiga Urinária/genéticaAssuntos
Cistos/diagnóstico , Epididimo , Adolescente , Criança , Doenças dos Genitais Masculinos/diagnóstico , Humanos , MasculinoRESUMO
Los quistes epidermoides intratesticulares en la infancia.No existen datos clínicos específicos que nos orienten hacia un diagnóstico de certeza., siendo necesario el estudio histopatológico. Basados en el caso presentado y en la revisión de la literatura, se analizan aspectos clínicos y diagnósticos.Aunque el tratamiento quirúrgico más utilizado ha sido la orquiectomía.Se recomienda al igual que otros autores, la enucleación del quiste y la conservación del testículo
Assuntos
Cisto Epidérmico/cirurgia , Testículo , PediatriaRESUMO
Los quistes epidermoides intratesticulares en la infancia.No existen datos clínicos específicos que nos orienten hacia un diagnóstico de certeza., siendo necesario el estudio histopatológico. Basados en el caso presentado y en la revisión de la literatura, se analizan aspectos clínicos y diagnósticos.Aunque el tratamiento quirúrgico más utilizado ha sido la orquiectomía.Se recomienda al igual que otros autores, la enucleación del quiste y la conservación del testículo
Assuntos
Pediatria , Cisto Epidérmico/cirurgia , TestículoRESUMO
Abdominal-scrotal hydrocele is an uncommon lesion, most specially during childhood. It is an entity, though, that should be included in the differential diagnosis of abdominal masses in children, and also considered as a likely cause of ureterohydronephrosis. Diagnosis is arrived at through ultrasound, CAT and occasional excretory urography. Radical surgical excision using inguinal access is the recommended approach, but sometimes the inguinoabdominal or pure abdominal approaches can be performed. Following surgical ablation the cure is complete, and includes remission of the ureterohydronephrosis when present. This paper reviews the literature, presents one case and discusses both the diagnostic possibilities and therapeutic alternatives.
Assuntos
Escroto , Hidrocele Testicular , Abdome , Doenças dos Genitais Masculinos/diagnóstico , Humanos , Lactente , Masculino , Hidrocele Testicular/diagnósticoRESUMO
PURPOSE: To study the morphological and biliary alterations associated with taurine-free parenteral nutrition and its other precursors. EXPERIMENTAL GROUPS: One fed a standard taurine-free amino acid formula, a group fed without taurine or its metabolic precursors, and a control group. At the beginning and end of the experiment, analyses were made of nutritional parameters, hepatic enzymes, biliary composition, plasmatic aminogram and optical and electronic microscopy of the liver. RESULTS: Significant increases of threonine, glutamine, alanine, lysine, histidine and arginine, and insignificant increases of taurine, serine, isoleucine and leucine in groups with PN. Increased Non-conjugated AB, particularly lithocholic and taurolithocholic acid in groups without taurine precursors. Fat microsteatosis in area 3 of the acinus in the group without taurine, and in the three areas in the group without precursors. Standard taurine-free PN causes changes in the biliary composition and liver histology, which increase in the absence of taurine precursors.