The role of enhanced recovery after surgery protocols in the development of acute kidney injury following radical cystectomy.

PURPOSE: Recent reports have suggested that fluid restriction as part of Enhanced Recovery after Surgery (ERAS) pathways may increase the risk of AKI in radical cystectomy (RC) patients. We sought to evaluate the impact of ERAS initiation on AKI incidence at a high-volume tertiary care center. MATERIALS AND METHODS: We performed a retrospective review of our IRB approved database to identify patients receiving RC from 2010 to 2019. ERAS was initiated at our institution in October 2016. Acute kidney injuries were graded according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria and must have occurred within 7 days of indexed RC. Estimated glomerular filtration rate (eGFR) was captured at baseline, 1, 3, 6, and 12 months respectively. Categorical variables were compared with the Pearson-Chi square test. Quantitative variables were analyzed with the Wilcoxon-Rank sum test. Multivariable binary logistic regression and interaction analysis was used to identify predictors of AKI. RESULTS: Twelve hundred patients were included. Twenty-two percent of patients experienced an AKI within 7 days. Patients in the ERAS cohort experienced less AKIs after RC (18% vs. 25%, P = 0.003). When adjusting for year of surgery, ERAS was not a significant predictor for AKI on multivariable analysis (OR: 0.87, P = 0.73). On interaction analysis, during the ERAS era, intracorporeal robot-assisted radical cystectomy (iRARC) was associated with decreased odds of AKI (OR: 0.39, P = 0.034). There were no significant differences in eGFR at 12 months postoperatively (P = 0.16). CONCLUSION: Unlike previous reports, ERAS initiation was not associated with increased risk of AKI at a tertiary care high-volume center.

Comparing Pathologic and Survival Outcomes Between Primary and Secondary Muscle Invasive Bladder Cancer When Treated by Radical Cystectomy With or Without Neoadjuvant Chemotherapy.

OBJECTIVE: To compare pathologic and survival outcomes between primary muscle invasive (pMIBC) and secondary muscle invasive (sMIBC) bladder cancer patients who were treated with or without cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC). METHODS: We reviewed cT2-T4/N0 MIBC patients at our institution between 2010-2019. pMIBC was defined as presenting with > cT2 disease on initial or restaging TURBT with no prior history of bladder cancer. sMIBC was defined as prior history of NMIBC that was treated with at least one induction course of BCG that progressed to MIBC. Outcomes analyzed included pathologic downstaging rates defined as pT2 and N+ disease were predictors of poorer CSS and OS. Separate analysis of sMIBC patients whom underwent RC only (N = 61), demonstrated inferior oncologic outcomes to other cohorts (P < .01). CONCLUSION: There were no differences in pathologic response or survival between pMIBC and sMIBC patients when managed with NAC and RC.

Uretero-Enteric Anastomotic Stricture Following Radical Cystectomy: A Comparison of Open, Robotic Extracorporeal, and Robotic Intracorporeal Approaches.

OBJECTIVES: To compare the incidence of benign uretero-enteric anastomotic strictures between open cystectomy, robotic cystectomy with extracorporeal urinary diversion, and robotic cystectomy with intracorporeal urinary diversion. The effect of surgeon learning curve on stricture incidence following intracorporeal diversion was investigated as a secondary outcome. PATIENTS AND METHODS: Patients who underwent radical cystectomy at an academic hospital between 2011 and 2018 were retrospectively reviewed. The primary outcome, incidence of anastomotic stricture over time, was assessed by a multivariable Cox proportional hazards regression. A Cox regression model adjusting for sequential case number in a surgeon's experience was used to assess intracorporeal learning curve. RESULTS: Nine hundred sixty-eight patients were included: 279 open, 382 robotic extracorporeal, and 307 robotic intracorporeal. Benign stricture incidence was 11.3% overall: 26 (9.3%) after open, 43 (11.3%) after robotic extracorporeal, and 40 (13.0%) after robotic intracorporeal. An intracorporeal approach was associated with anastomotic stricture on multivariable analysis (HR 1.66; P = .05). After 75 intracorporeal cases, stricture incidence declined from 17.5% to 4.9%. Higher sequential case volume was independently associated with reduced stricture incidence (Hazard Ratio per 10 cases: 0.90; P = .02). CONCLUSION: An intracorporeal approach to urinary reconstruction following robotic radical cystectomy was associated with an increased risk of benign uretero-enteric anastomotic stricture. In surgeons' early experience with intracorporeal diversion the difference in stricture incidence was more pronounced compared to alternative approaches; however, increased intracorporeal case volume was associated with a decline in stricture incidence leading to a modest difference between the 3 surgical approaches overall.

Técnicas de acceso, plataformas e instrumentos de LESS / Access techniques, platforms and instruments for less

OBJECTIVES: To summarize the available tools available for performing Laparo Endoscopic Single-Site surgery in Urology. METHOD: A comprehensive electronic literature search was conducted in May 2011 using the Medline database to identify all publications relating to NOTES and LESS in urology and information on devices were also obtained by accessing company Websites. RESULTS: Multiple access ports are available and allow to insert several instruments through multiple channels inside a larger single port. Due to lack of triangulation intracorporally, companies developed various articulating and bent instruments, limiting clashing and allowing increased working space. The ideal endoscope for LESS should remove the light cord and camera head from Arch. Esp. Urol. 2012; 65 (3): 285-293Keywords: Laparoendoscopic Single-Site Surgery LESS. Natural Orifice Transluminal Endoscopic Surgery NOTES. Urology. Devices. the operative field. Articulating and low profile scopes are now available. Furthermore, surgeons can use extra-long scopes. CONCLUSION: Various tools currently are available for single-site surgery. Randomized studies are needed to determine the Platform selection(AU)

OBJETIVO: Resumir los instrumentos disponibles para realizar cirugía laparoendoscópica por puerto único en Urología. MÉTODOS: Se llevó a cabo una búsqueda electrónica exhaustiva de la literatura en Mayo del 2011 utilizando la base de datos Medline para identificar todas las publicaciones relacionadas con NOTES y LESS en urología y también se obtuvo la información sobre los aparatos accediendo a las páginas web de las compañías. RESULTADOS: Hay múltiples puertos de acceso disponibles y permiten la inserción de varios instrumentos a través de múltiples canales en el interior de un puerto único más grande. Debido a la falta de triangulación intracorpórea las compañías han desarrollado diferentes instrumentos articulados y pre-curvados, limitando el choque entre instrumentos y permitiendo aumentar el espacio de trabajo. El endoscopio ideal para LESS debería eliminar el cable de luz y el cabezal de cámara del campo operatorio. Actualmente están disponibles endoscopios articulados y de bajo perfil. Además, los cirujanos pueden utilizar endoscopios extralargos. CONCLUSION: Actualmente hay diferentes herramientas disponibles para la cirugía de puerto único. Son necesarios estudios aleatorizados para determinar la selección de plataforma(AU)

Flexible robotic retrograde renoscopy: description of novel robotic device and preliminary laboratory experience.

OBJECTIVES: To describe a novel flexible robotic system for performing retrograde intrarenal surgery. METHODS: Remote robotic flexible ureterorenoscopy was performed bilaterally in 5 acute swine (10 kidneys). A novel 14F robotic catheter system, which manipulated a passive optical fiberscope mounted on a remote catheter manipulator was used. The technical feasibility, efficiency, and reproducibility of accessing all calices were assessed. Additionally, laser lithotripsy of calculi and laser ablation of renal papillae were performed. RESULTS: The robotic catheter system could be introduced de novo in eight ureters; two ureters required balloon dilation. The ureteroscope could be successfully manipulated remotely into 83 (98%) of the 85 calices. The time required to inspect all calices within a given kidney decreased with experience from 15 minutes in the first kidney to 49 seconds in the last (mean 4.6 minutes). On a visual analog scale (1, worst to 10, best), the reproducibility of caliceal access was rated at 8, and instrument tip stability was rated at 10. A renal pelvic perforation constituted the solitary complication. Histologic examination of the ureter showed changes consistent with acute dilation without areas of necrosis. CONCLUSIONS: A novel robotic catheter system is described for performing retrograde ureterorenoscopy. The potential advantages compared with conventional manual flexible ureterorenoscopy include an increased range of motion, instrument stability, and improved ergonomics. Ongoing refinement is likely to expand the role of this technology in retrograde intrarenal surgery in the near future.

Scarless single port transumbilical nephrectomy and pyeloplasty: first clinical report.

OBJECTIVE: To report the initial clinical cases of scarless, single port, transumbilical nephrectomy and pyeloplasty. PATIENTS AND METHODS: One patient each underwent single port transumbilical nephrectomy and pyeloplasty using the R-Port (Advanced Surgical Concepts), inserted through a transumbilical incision in both cases. Novel, specialized instruments, curved at the shaft, were used in addition to standard laparoscopic instrumentation. During pyeloplasty, a 2-mm needle-port (MiniSite, USSC, Norfolk, CT, USA) was also inserted, with no skin incision, to facilitate suturing. RESULTS: Both procedures were technically successful with no extra-umbilical skin incisions. The total operative duration was 3.4 and 2.7 h, the estimated blood loss 100 and 50 mL, and the hospital stay was 1 and 2 days for the nephrectomy and pyeloplasty, respectively. There were no complications during or after surgery. The total analgesia requirement was 100 and 150 mg of keterolac, and visual analogue pain scores were 8/10 and 2/10 at 1 and 2 days after surgery, respectively. CONCLUSIONS: Transumbilical, single port nephrectomy and pyeloplasty are technically feasible. The first initial clinical experience of organ-ablative and reconstructive renal surgery with this approach is reported.