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Objective To investigate the epidemiological and clinical characteristics of hand,foot and mouth disease(HFMD) complicated with central nerve system infection,in order to improve the diagnosis and treatment.Methods Total of 569 cases of HFMD complicated with central nerve system infection were enrolled.The results of pathogen detection and CSF examination were looked into,and epidemiological and clinical characteristics were analyzed retrospectively.Results HFMD of the central nervous system infections increased year by year,endanger the children's life,pathogen detection showed positive for enterovirus type 71 (640/1077,59.4％) and coxsackie virus infection in group A (158/1077,14.7％) ; Clinical manifestation:hand,foot and mouth,hips were rash (100.0％),fever(546/569,95.9.％),temperature higher than 38.5 ℃ (74.7％,425/569),there were various signs and symptoms of nervous system damage,sleepiness (187/569,32.9％),limb jitter(347/569,60.1％),easily frightened (405/569,71.2％),irritability (130/569,22.8％),convulsions (2.4％,14/569),vomiting (67/569,11.8％),choking cough (2.8 ％,16/569),irregular breathing (0.5 ％,3/569) ; Laboratory examination:the central nervous system complications in different CFPro (P =0.992),CFWBC (P =0.994) and CRP (P =0.786),no statistical difference in such aspects of brain stem encephalitis group in CFP(P =0.001),PWBC (P =0.000) and BG (P =0.000),and the differences were statistically significant; Short-term,the combination of large dose of gamma globulin and methylprednisolone had definite efficacy.Conclusion HFMD complicated with central nervous system infections have some epidemiological and clinical characteristics,early diagnosis and treatment can reduce the incidence of severe cases and mortality.
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Objective To discuss the epidemiological and clinical features of patients with AIDS initially diagnosed as Pneumocystis carinii pneumonia(PCP).Methods The retrospective epidemiological survey and clinical study was conducted on the material from 71 patients with AIDS who were initially diagnosed as PCP.Results All cases in this group were admitted to hospital in a critical condition,with fever,dry cough,fatigue,dyspnea and hypoxemia; X-ray and CT showed increased lung markings,thickening,miliary and (or) ground glass-like changes 67 cases (62.0％) ;most cases had significantly lower CD4+ T lymphocyte and peripheral blood lymphocyte counts,leading to a high death rate.PCP were used sulfamethoxazole therapy,64 cases crued,7 death.Conclusion PCP in AIDS has clinical and epidemiological characteristics.Paying more attention to epidemiological survey,along with timely confirmation and treatment will be beneficial to improve the prognosis of PCP.
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0.05),the average recovery periods of TBIL,AKP and rGT were shorter in trial group than in control group(P
