The mediating effect of self-efficacy between self-disclosure and medical coping modes in adolescents with depression / 中华行为医学与脑科学杂志

Objective:To analyze the relationship between self-disclosure, self-efficacy and medical coping modes in adolescent depression, and explore the mediating effect of self-efficacy between self-disclosure and medical coping modes.Methods:Using the convenience sampling method, a total of 403 adolescents with depression in a tertiary psychiatric hospital in Beijing were recruited from March 2020 to March 2021. The data of general information questionnaire, distress disclosure index scale, medical coping modes questionnaire and general self-efficacy scale were collected.SPSS 26.0 software was used to analyze the correlation between self-disclosure, self-efficacy and medical coping modes of adolescent patients with depression, and Stata 13.1 software was used to analyze the mediating effect of self-efficacy between self-disclosure and medical coping modes.Results:The scores of dimension of the medical coping modes of adolescent depression patients were(16.90±3.84) for facing, (16.34±2.88) for yielding, (12.48±4.31) for avoiding, (30.47±9.91) for self-disclosure and (19.63±6.54) for self-efficacy, respectively. Self-disclosure and self-efficacy were positively correlated with facing of medical coping modes ( r=0.301, 0.327, both P<0.01), and negatively correlated with yielding of medical coping modes ( r=-0.465, -0.487, both P<0.01). Self-disclosure was negatively correlated with avoidance of medical coping modes ( r=-0.118, P=0.018). The direct effect of self-efficacy on medical coping modes was 0.103, and the total effect was 0.365, and the mediating effect accounted for 28.22%. Conclusion:Self-efficacy partially mediates between self-disclosure and medical coping modes in adolescents with depression.

Multi-chain Fudan-CCDC model for COVID-19 -- a revisit to Singapore's case

BackgroundCOVID-19 has been impacting on the whole world critically and constantly since late December 2019. Rapidly increasing infections has raised intense world-wide attention. How to model the evolution of COVID-19 effectively and efficiently is of great significance for prevention and control. MethodsWe propose the multi-chain Fudan-CCDC model based on the original single-chain model in [8] to describe the evolution of COVID-19 in Singapore. Multi-chains can be considered as the superposition of several single chains with different characteristics. We identify parameters of models by minimizing the penalty function. ResultsThe numerical simulation results exhibit the multichain model performs well on data fitting. Though unsteady the increments are, they could still fall within the range of {+/-}25% fluctuation from simulation results. It is predicted by multi-chain models that Singapore are experiencing a nonnegligible risk of explosive outbreak, thus stronger measures are urgently needed to contain the epidemic. ConclusionThe multi-chain Fudan-CCDC model provides an effective way to early detect the appearance of imported infectors and super spreaders and forecast a second outbreak. It can also explain the data in those countries where the single-chain model shows deviation from the data.

CoVID-19 in Japan: What could happen in the future?

COVID-19 has been impacting on the whole world critically and constantly Since December 2019. We have independently developed a novel statistical time delay dynamic model on the basis of the distribution models from CCDC. Based only on the numbers of confirmed cases in different regions in China, the model can clearly reveal that the containment of the epidemic highly depends on early and effective isolation. We apply the model on the epidemic in Japan and conclude that there could be a rapid outbreak in Japan if no effective quarantine measures are carried out immediately.

Epidemiology of cerumen impaction among municipal kindergartens children in Wuhan, China.

OBJECTIVE: To investigate the epidemiology of cerumen impaction among children of municipal kindergartens in Wuhan. METHODS: The ear canal of children of municipal kindergartens in Wuhan was examined using an electric otoscope by the same otologist in 2005, 2006 and 2012, with age, gender, ears and the nature of cerumen (dry cerumen or wet cerumen) recorded. A chi-square test was performed to investigate for significant differences between cerumen impaction rates and the recorded variables. RESULTS: A total of 1,214, 1863 and 5205 children were examined in 2005, 2006 and 2012, and cerumen impaction prevalence rates for each year were 17.2%, 15.4% and 10%, respectively. Prevalence of cerumen impaction was significantly lower in 2012 than in 2005 or 2006. In 2005, dry cerumen impaction accounted for 22.2% of the total dry cerumen, while wet cerumen impaction only accounted for 5% of the total wet cerumen, showing a statistically significant difference. CONCLUSION: The prevalence of cerumen impaction among children of kindergartens in Wuhan is higher than 10%, and children with dry cerumen are more prone to cerumen impaction. Annual otological examination of kindergarten children is recommended. And improved community ear health promotion activities should reduce the avoidable prevalence of cerumen impaction in pediatric population.

Simultaneous Determination of 6 Residual Organic Solvents in Xingnaojing Injection by Headspace GC / 中国药房

OBJECTIVE:To establish the method for simultaneous determination of 6 residual organic solvents in Xingnaojing injection,such as methanol,ethanol,isopropanol,n-butanol,ethyl acetate and acetonitrile.METHODS:Headspace GC method was adopted.The determination was performed on DB-624 capillary column by temperature programming with the injector temperature of 200 ℃;flame ionization detector was adopted with the temperature of 250 ℃;carrier gas was nitrogen with flow rate of 25 mL/min and split ratio of 35 ∶ 1;headspace sampling size was 1 mL,and heating temperature of headspace sampling was 80 ℃;equilibrium time was 15 min.RESULTS:The linear ranges of methanol,ethanol,isopropanol,n-butanol,ethyl acetate and acetonitrile were 15.00-240.00 μg/mL (r =0.999 9),25.00-400.00 μg/mL (r =0.999 9),25.00-400.00 μg/mL (r =0.999 9),25.00-399.99 μg/mL(r=0.999 9),25.00-399.99 μg/mL(r=0.999 8) and 5.00-80.00 μg/mL(r=0.999 9).The LOQ were 5.98,3.94,2.05,2.13,1.39,1.24 μg/mL,and the LOD were 2.01,2.11,1.18,1.56,1.15,0.01 μg/mL,respectively.RSDs of precision tests were all less than 2.0％,stability and repetitive tests only ethyl acetate was detected,RSD＜2.0％;the recoveries were 93.59％-99.02％ (RSD=2.62％,n=6),92.42％-98.40％ (RSD=2.43％,n=6),94.81％-104.64％ (RSD=3.47 ％,n=6),94.56％-106.73％ (RSD=4.21％,n=6),97.04％-106.33％(RSD=3.50％,n=6)and 98.40％-107.97％ (RSD=3.37％,n=6).CONCLUSIONS:The method is specific,rapid,simple and accurate,and can be used for simultaneous determination of 6 residual organic solvents in Xingnaojing injection.

Simultaneous Determination of 6 Residual Organic Solvents in Xingnaojing Injection by Headspace GC / 中国药房

OBJECTIVE:To establish the method for simultaneous determination of 6 residual organic solvents in Xingnaojing injection,such as methanol,ethanol,isopropanol,n-butanol,ethyl acetate and acetonitrile.METHODS:Headspace GC method was adopted.The determination was performed on DB-624 capillary column by temperature programming with the injector temperature of 200 ℃;flame ionization detector was adopted with the temperature of 250 ℃;carrier gas was nitrogen with flow rate of 25 mL/min and split ratio of 35 ∶ 1;headspace sampling size was 1 mL,and heating temperature of headspace sampling was 80 ℃;equilibrium time was 15 min.RESULTS:The linear ranges of methanol,ethanol,isopropanol,n-butanol,ethyl acetate and acetonitrile were 15.00-240.00 μg/mL (r =0.999 9),25.00-400.00 μg/mL (r =0.999 9),25.00-400.00 μg/mL (r =0.999 9),25.00-399.99 μg/mL(r=0.999 9),25.00-399.99 μg/mL(r=0.999 8) and 5.00-80.00 μg/mL(r=0.999 9).The LOQ were 5.98,3.94,2.05,2.13,1.39,1.24 μg/mL,and the LOD were 2.01,2.11,1.18,1.56,1.15,0.01 μg/mL,respectively.RSDs of precision tests were all less than 2.0％,stability and repetitive tests only ethyl acetate was detected,RSD＜2.0％;the recoveries were 93.59％-99.02％ (RSD=2.62％,n=6),92.42％-98.40％ (RSD=2.43％,n=6),94.81％-104.64％ (RSD=3.47 ％,n=6),94.56％-106.73％ (RSD=4.21％,n=6),97.04％-106.33％(RSD=3.50％,n=6)and 98.40％-107.97％ (RSD=3.37％,n=6).CONCLUSIONS:The method is specific,rapid,simple and accurate,and can be used for simultaneous determination of 6 residual organic solvents in Xingnaojing injection.

Effects of Perioperative Application of ELP Enteric Soft Capsules on Therapeutic Efficacy and Prognosis in Children after Grommet Insertion of Chronic Secretory Otitis Media / 中国药房

OBJECTIVE:To investigate the effects of perioperative application of Eucalyptol,limonene and pinene(ELP)en-teric soft capsules on therapeutic efficacy and prognosis in children after grommet insertion of chronic secretory otitis media. METH-ODS:92 cases(145 ears)of chronic secretory otitis media were divided into 2 groups by random number table method,including 46 cases in observation group(68 ears)and 46 cases in control group(77 ears). Both groups received grommet insertion under gen-eral anesthesia by otomicroscope. Control group was not given any drugs;observation group was given ELP enteric soft capsules 1.2 g,bid,from 3 d before operation to 5 d after operation. Subjective therapeutic efficacy and pure tone audiometry of 2 groups were observed 3 days,5 days,2 weeks,1 month and 3 months after surgery as well as acoustic impedance monitoring in children with tube withdrawal from ear 1 month and 3 months after surgery. RESULTS:The total effective rates of observation group 3 days,5 days,2 weeks,1 month and 3 months after surgery were 72.06%,82.35%,85.29%,89.70%and 95.59%;those of con-trol group were 59.74%,66.23%,80.52%,87.01% and 92.21%,with statistical significance(P<0.05). The pure tone audiome-try score of observation group 3 days,5 days,2 weeks,1 month and 3 months after surgery were significantly lower than those of control group,with statistical significance(P<0.05). Therapeutic effective rates of acoustic impedance monitoring in children with tube withdrawal from ear 1 month and 3 months after surgery were 77.78% and 90.48% in observation group,which were signifi-cantly higher than 61.54% and 81.48% in control group,with statistical significance(P<0.05). CONCLUSIONS:The periopera-tive application of ELP enteric soft capsules can significantly improve function recovery and hearing level in children after grommet insertion of chronic secretory otitis media.

An AnaIysis of EIectron-nasopharyngoIaryngoscopy ResuIts in 4 668 ChiIdren with Hoarseness / 听力学及言语疾病杂志

Objective To study the causes and clinical features associated with hoarseness in children.Meth-ods The data of 4 668 children suffering from hoarseness were analyzed with electronic-nasopharyngolaryngosco-py retrospectively.ResuIts The top 6 common causes of hoarseness were chronic laryngitis (1 817 cases,38.9%), vocal cord nodules (1 494 cases,32.0%),vocal hypertrophy (560 cases,12.0%),the paralysis of vocal cord (373 cases,8.0%),congenital sulcus vocalis (149 cases,3.2%)and recurrent respiratory papilloma disease (140 cases,3. 0%).These six diseases were common in children with hoarseness with 4 533 out of 4668 (97.1%);of the chil-dren were 2 to 10 years old as the largest age group (65.8%,3 072/4 668)and the ratio of male and female was 2. 48:1.The top six diseases were statistically distributed in different age groups (P<0.01).ConcIusion The main causes of hoarseness were different in different age groups.The children aged 2 to 10 years old made up the largest group (3 072/4 668),showing the greatest incidence of hoarseness in children .The incidence for male patients was higher than female and the chronic laryngitis was the top disease.Hoarseness in children was different from that of adults so that to understand the characteristics of this disorder in children will be beneficial to the proper diagnosis and effective treatment.

Application study on supervision system of hospital-university collaboration in class teaching of nursing undergraduates / 中国实用护理杂志

Objective To evaluate the application effect of supervision system of hospital-university collaboration on class teaching of nursing undergraduates,so as to provide reference to promote the link-up between nursing theory and clinical practices.Methods The supervision group of hospital-university collaboration were formed by selecting 30 excellent clinical instructors from university-affiliated hospitals and 12 nursing teachers,they listened to the teachers in classes randomly and recorded,simultaneously filled in rating forms about the class with students.Supervision meetings were held and targeted strategies were put down regularly,their effects were evaluated through interview and investigation methods.Results Professional teachers accepted their suggestions and took some actions to make a change.The results of rating forms showed that the quality of classroom teaching were improved gradually.Conclusions The supervision system of hospital-university collaboration can enhance the sense of responsibility of teaching,contribute to the integration between the hospital and university.It should be continued as a long-run system.

Clinical analysis of foreign body ingestion of button cell in children / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To improve diagnosis and treatment level of foreign body ingestion of button cell in children.@*METHOD@#Among the 14 cases with foreign bodies ingestion of button cell, 6 cases in esophageal, 7 cases in stomach and lower gastrointestinal tract, 1 case with multiple foreign bodies both in esophagus and stomach. Seven cases in stomach and lower gastrointestinal tract were closely observed without special treatment, 6 cases in esophageal, underwent esophagoscopy and removal of foreign body under general anesthesia, 1 case with multiple foreign bodies in esophagus and stomach underwent esophagoscopy and electronic gastroscopy and then removal of foreign body. All patients had symptomatic treatments after removal of foreign body. The average age is 2 years and 1 month.@*RESULT@#After the removal of button cell, Foreign bodies in stomach and lower gastrointestinal tract in 7 cases were all discharged spontaneously. For the 6 cases in esophagus, 4 cases were cured, 1 case had esophageal stricture, 1 cased died. 1 case with multiple foreign bodies in both esophagus and stomach was cured.@*CONCLUSION@#Esophageal foreign body has strong corrosiveness and would cause serious damages even to threaten children's life. It also may lead to esophageal stricture. The key point to cure this disease is to diagnose timely and to operate as soon as possible. Because neutralize of digestive juices and low probability of incarceration, with close observation, the foreign bodies of stomach and lower gastrointestinal tract can discharge spontaneously.

The analysis of depression,anxiety and sleep disorder in earthquake-related injuries / 中华内科杂志

During the psychological intervention for patients injured and patients with internal disease in earthquake in Sichuan,psychological assessment of anxiety,depression and sleep disorder was carried for them by conversation and observation.By analysis,it showed that the patients suffering from depression and anxiety was 41.8% and sleep disorder WaS 73%.Further more,sleep disorder was significantly correlated with depression and anxiety.

The curative effect of livostin spray on treating allergic rhinitis of children / 临床耳鼻咽喉头颈外科杂志

Objective:To observe the effect of Livostin spray on children＇s allergic rhinitis and to search the mechanism of treating allergic rhinitis. Method: 113 patients were treated with Livostin spray (Livostin group) or normal saline spray (control group). Result:The total efficiency of Livostin group in treating allergic rhinitis is above 95.1％ and that of the control group is 25.0％. Initial time of starting effect of Livostin (72.1％) is in 1 minute, and that of the control group (mostly 23.1％) is in 3 minutes. The keeping curativeeffect time of Livostin spray is mostly (72.1％) above 5 hours and that of the control group is mostly (30.8％) in 3 hours. After 2 weeks,the eosinophilic granulocyte number in nose＇s secretion of Livostin group is obviously reduced (P＜0.05). Conclusion: Livostin is better than control group in relieving symptoms, keeping curative effect and safety,so Livostin is one kind of effective drug in treating children＇s allergic rhinitis.

Investigation on situation and needs for health education of AIDS preven tion in high school students in Anhui / 中华疾病控制杂志

Objective　In order to understand situation and need s for health education of AIDS prevention in high school students in Anhui. Methods　1 617 students from 12 schools in 4 prefectures were sur veyed with questionnaires. Results　More than 50% students got the i nformation from newspaper, broadcasting, TV. Only 7.5% and 4.7% st udents acquired the info rmation from the subject lectures at school level and class level respectively. 14.4% students attended health education activities f or AIDS prevention. 10.9% students received relevant pro paganda materials, 77.8% students had never seen condom, 44.1% students knew the function of condom, and 8.6% students approved of premarital sexual life, of wh ich , ratio of male students were significantly higher than that of female students. More than 70% students were willing to care and help patients with HIV infectio n. Conc lusions　It is necessary and possible to develop health education for AI DS prevention in high school students. It is an important measure to develop hea lth education to block HIV transmission.

Study of blockading Stat3 by transcription factor decoy-ODN inhibiting the proliferation of breast cancer cell line MDA-MB-231 / 中国免疫学杂志

Objective:To investigate the mechanisms of decoy oligodeoxynucleotides(decoy-ODN) blockading Stat3 that inhibit breast cancer cells MDA-MB-231 proliferation.Methods:Stat3 decoy-ODN and scramble control were transfected into breast cell line MDA-MB-231, respectively. The cell proliferation capability was detected by cell counting; flow cytometry was applied to detect MDA-MB-231 cell cycle; FITC labeled decoy was observed by Reflected Light Fluorescence Microscope; the expression of the gene controlled by Stat3 was examined by means of RT-PCR and Western blot assay.Results:Stat3 decoy-ODN could be internalized into MDA-MB-231 cells and inhibit the growth of MDA-MB-231 cell via inducing its apoptosis. Stat3 decoy-ODN also could significantly reduce the expression of Stat3 controlling genes such as Bcl-xl,c-myc and CylinD1.Conclusion:Stat3 decoy-ODN can inhibit breast cell line MDA-MB-231 proliferation by blockading JAK/STAT pathway. This suggests that transcription factor decoy-ODN may serve as a novel therapeutic strategy for breast cancer.

Effect of Tanshinone on human polymorphonuclear leucocyte chemokinesis / 中国病理生理杂志

The paper studied effect of different doses of Tanshinone on human polymorphonuclear leucocyte chemokinesis by agarose microdroplet assay. The results indicate that more than 10ng/ml Tanshinone inhibites significantly human polymorphonuclear leucocyte chemokinetic response to 10~(-9)M FMLP. This inhibitory effect is probably one of mechanisms of Tanshinone anti-inflammatory activity. The agarose microdroplet assay is a reliable mothod for studying leucocyte chemokinesis in vitro.