Regional Variant Analysis of Spike Glycoprotein Mutations of SARS-CoV-2 and Its Implications in COVID-19 Pandemic Control

Mutations in the spike glycoprotein have various impacts on the receptor binding, antibody interaction, and host range of SARS-CoV-2. As the interaction of spike glycoprotein with the human ACE2 receptor is the entry point of SARS-CoV-2 in human cells, mutations in the spike protein itself contain numerous impacts on the pandemic. Here, we analysed all the mutations in the spike glycoprotein from123 strains isolated from Kerala, India. We also predicted the possible structural relevance of the unique mutations based on topological analysis of the residue interaction network of the spike glycoprotein structure.