Concomitância síndrome de hellp e dengue na gestação: relato de caso / Concomitance of hellp syndrome and dengue in pregnancy: case report / Concomitancia del síndrome hellp y el dengue en el embarazo: reporte de un caso

Introdução: Dengue e Síndrome de Hellp caracterizam-se por um quadro clínico semelhante e ambas possuem elevada incidência no Brasil. Assim, pode ocorrer o subdiagnóstico da condição em que ambas coexistem em uma mesma gestação. Objetivo: Descrever um caso da sobreposição de Hellp síndrome e Dengue na gestação visto a escassez dessa na literatura médica. Método: As informações foram obtidas por meio de revisão do prontuário e acompanhamento da paciente na Unidade de Terapia Intensiva. Resultado: Constatouse ser difícil realizar o diagnóstico diferencial da Hellp síndrome e da Dengue, e da associação de ambas, na gestação. Conclusão: Devido à escassez na literatura da associação de Dengue e Síndrome Hellp, e o elevado potencial de morbimortalidade, julgou-se relevante a publicação do caso para contribuição e orientação na condução médica em casos semelhantes.(AU)

Introduction: Dengue and Hellp's Syndrome are characterized by a similar clinical picture and both have a high incidence in Brazil. Thus, there may be an underdiagnosis of the condition in which both coexist in the same pregnancy. Objective: To describe a case of overlapping Hellp syndrome and Dengue during pregnancy, given the scarcity of this in the medical literature. Method: The information was obtained by reviewing the medical record and monitoring the patient in the Intensive Care Unit. Result: It was found to be difficult to make the differential diagnosis of Hellp syndrome and Dengue, and the association of both, during pregnancy. Conclusion: Due to the scarcity in the literature of the association of Dengue and Hellp syndrome, and the high potential for morbidity and mortality, it was considered relevant to publish the case for contribution and guidance in medical management in similar cases.(AU)

Introducción: El dengue y el síndrome de Hellp se caracterizan por un cuadro clínico similar y ambos tienen una alta incidencia en Brasil. Por lo tanto, puede haber un diagnóstico insuficiente de la afección en la que ambos coexisten en el mismo embarazo. Objetivo: Describir un caso de superposición síndrome Hellp y Dengue en el embarazo dada la escasez de esto en la literatura médica. Métodos: La información se obtuvo mediante la revisión de la historia clínica y el seguimiento del paciente en la Unidad de Cuidados Intensivos. Resultado: Se descubrió que era difícil realizar el diagnóstico diferencial del síndrome Hellp y el Dengue, y la asociación de ambos, en el embarazo. Conclusión: Debido a la escasez en la literatura de la asociación del Dengue y el síndrome de Hellp, y el alto potencial de morbilidad y mortalidad, se consideró relevante publicar el caso para su contribución y orientación en el manejo médico en casos similares.(AU)

Analysis of the common bean (Phaseolus vulgaris L.) transcriptome regarding efficiency of phosphorus use.

Common bean is a highly important food in tropical regions, where most production occurs on small farms with limited use of technology and, consequently, greater vulnerability to abiotic stresses such as nutritional stress. Usually phosphorus (P) is the most limiting nutrient for crop growth in these regions. The aim of this study was to characterize the gene expression profiles of the genotypes of common bean IAC Imperador (P-responsive) and DOR 364 (P-unresponsive) under different P concentrations using RNA-seq transcriptome sequencing technology. Plants were grown hydroponically, with application of two P concentrations (4.00 mg L-1 restrictive level and 8.00 mg L-1 control level). Differential expression analyses, annotation, and functional classification were performed comparing genotypes within each P rate administered and comparing each genotype response to the different P levels. Considering differential expression analyses within genotypes, IAC Imperador exhibited 1538 up-regulated genes under P restriction and 1679 up-regulated genes in the control, while DOR 364 exhibited 13 up-regulated genes in the control and only 2 up-regulated genes under P restriction, strongly corroborating P-unresponsiveness of this genotype. Genes related to phosphorus restriction were identified among the differentially expressed genes, including transcription factors such as WRKY, ERF, and MYB families, phosphatase related genes such as pyrophosphatase, acid phosphatase, and purple acid phosphatase, and phosphate transporters. The enrichment test for the P restriction treatment showed 123 enriched gene ontologies (GO) for IAC Imperador, while DOR 364 enriched only 24. Also, the enriched GO correlated with P metabolism, compound metabolic processes containing phosphate, nucleoside phosphate binding, phosphorylation, and also response to stresses. Thus, this study proved to be informative to phosphorus limitation in common bean showing global changes at transcript level.