Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Rev Hosp Clin Fac Med Sao Paulo ; 57(6): 257-64, 2002.
Artigo em Inglês | MEDLINE | ID: mdl-12612757

RESUMO

INTRODUCTION: Traumatic spinal cord injury is one of the most disabling conditions occurring in man and thus stimulates a strong interest in its histopathological, biochemical, and functional changes, primarily as we search for preventive and therapeutic methods. PURPOSE: To develop an experimental model for transplantation of cells from the fetal rat central nervous system to the site of an injured spinal cord of an adult rat in which the transplanted cells survive and become integrated. This experimental model will facilitate investigations of factors that promote regeneration and functional recovery after spinal cord trauma. MATERIAL AND METHODS: Fifteen adult Wistar rats underwent laminectomy, and an spinal cord lesion was made with microdissection. Fetal spinal cord tissue was then transplanted to the site of the injury. The rats were monitored over a 48-hour period, and then their vertebral column was completely removed for histological analysis. RESULTS: In 60% of transplanted rats, the fetal tissue at the injured site remained viable in the site of the lesion.


Assuntos
Transplante de Tecido Fetal/métodos , Traumatismos da Medula Espinal/cirurgia , Medula Espinal/transplante , Transplante de Células-Tronco , Animais , Modelos Animais de Doenças , Feminino , Masculino , Tecido Nervoso , Ratos , Ratos Wistar , Medula Espinal/citologia , Medula Espinal/embriologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA