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Objective To investigate the diagnostic accuracy of serum interleukin-8 (IL-8) in predicting severe acute pancreatitis (SAP) by conducting a Meta-analysis.Methods Publications addressing the diagnostic accuracy of serum IL-8 in the diagnosis of SAP were selected from Pubmed,Embase,Cochrane library,CBM,Wanfang,VIP,and CNKI databases.Data analysis was conducted by STATA 9.2software.Results According to the inclusion criteria,five diagnosis tests were retrieved,including 299 SAP patients and 2956 healthy controls.Meta-analysis results showed that the pooled sensitivities of IL-8 were 65.8％and 70.9％ for days 1 and 2,respectively; the pooled specificities were 66.5％ and 91.3％ for days 1 and 2,respectively; the pooled positive predictive value were 54.7 and 86.2 for days 1 and 2,respectively; the pooled negative predictive value were 75.9 and 80.3 for days 1 and 2,respectively; the area under curve (AUC) were 0.73 (95％ CI:0.21-0.97) and 0.91 (95％ CI:0.85-0.92) for days 1 and 2,respectively; and the diagnostic odds ratio (DOR) were 6.1 (95％ CI:2.8-13.2) and 23.4(95 ％ CI:8.1-63.7) for days 1 and 2,respectively.Conclusions Serum IL-8 on day 1 and 2 seems to perform high accuracy in predicting SAP,but diagnosis accuracy of serum IL-8 on day 1 was superior than that on day 1.Serum IL-8 might be an important tool for early prediction and diagnosis of SAP.
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Objective To explore the changes of IL-6, IL-8 and TNF-? levels before and after pericardial(devascularization) associated with proximal spleno-renal shunt(combined operation) in cirrhotic patients with portal hypertension. Methods Plasma levels of IL-6, IL-8 and TNF-? in combined(operation ) patients at 1d before(operation),and 7d after operation were measured and compared with control group. Results Preoperatively, the(plasma) levels of IL-6[ (230.4?10.3) ng/L], IL-8 [ (201.5?7.8) ng/L]and TNF-?[ (261.5?28.3) ng/L]in(combined) operation patients were significantly higher than those in control group (P
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Objective To observe the effect of Tongfu Xiere Recipe (TXP) combined with routine treatment on cytokine level in patients with acute lung injury due to surgery disease of chest. Methods Fifty eight patients with acute lung injury due to surgery disease of chest were randomized into two groups. The two groups received routine treatment subjecting to the Guideline (2006) for Diagnosis and Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome. The treatment group additionally received TXP (mainly composed of Radix et Rhizoma Rhei, Natrii Sulfas, Fructus Gardeniae, Caulis Lonicerae, Herba Taraxaci, Semen Raphani, Semen Lepidii seu Descurainiae, Rhizoma Polygoni Cuspidati, Radix Paeoniae Rubra, Fructus Aurantii Immaturus, and Cortex Magnoliae Officinalis) for 5 days or till oxygenation index recovered to the normal. The therapeutic effect was evaluated after treatment, and the changes of blood tumor necrosis factor ? (TNF-?), interleukin 6 (IL-6) and interleukin 8 (IL-8) levels were observed before and after treatment. Results The serum levels of TNF-?, IL-6 and IL-8 in the two groups after treatment were decreased (P0.05). Conclusion The therapeutic effect of traditional Chinese medicine integrated with western medicine is superior to the western medicine only for acute lung injury due to surgery disease of chest. TXP can regulate the immune function and relieve the pulmonary inflammation and injury by decreasing the blood levels of TNF-?, IL-6 and IL-8, thus enhance the therapeutic effect of western medicine.
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Objective To investigate the effect of Xiongshang RecipeⅠ(XPI)on serum inflammatory cytokines of tumor necrosis factor (TNF)and interleukin-8(IL-8)in acute pulmonary contusion patients.Methods Thirty acute pulmonary contusion patients were equally randomized into the control group (receiving routine western medical treatment)and the treatment group (received routine western medical treatment and oral use of XPI).The treatment lasted 2 weeks.Thirty healthy physical examinees served as the contemporaneous normal controls.Secondary pulmonary contusion,recovery time and the serum levels of TNF and IL-8 were observed after pulmonary contusion.Results Serum levels of TNF and IL-8 in the treatment group after treatment were decreased(P
