RESUMO
OBJECTIVE: To explore the effect ofß-TCP/PLLA scaffold in repairing rabbit radial bone defects. METHODS: Thirty New Zealand rabbits were divided into ß-TCP /PLLA group (group A), pure PLLA group (group B) and contrast group (group C) randomly. The rabbits were sacrificed respectively after 4, 8, 12, 24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups. RESULTS: X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A. The defect region was filled with neonate osseous tissue completely during 12-24 weeks. X-ray score revealed that repair of bone defect results significantly better than group B and group C. CONCLUSIONS: The ß-TCP /PLLA composite is capable of repairing radial bone bone defects. ß-TCP/PLLA scaffold is significant because of rapid degradation ability, good histocompatibility and osteogenic action.
Assuntos
Doenças Ósseas/terapia , Substitutos Ósseos/química , Fosfatos de Cálcio/química , Poliésteres/química , Rádio (Anatomia)/anormalidades , Alicerces Teciduais/química , Animais , Fenômenos Biomecânicos , Densidade Óssea , Doenças Ósseas/fisiopatologia , Doenças Ósseas/cirurgia , Humanos , Masculino , Polímeros/química , Coelhos , Rádio (Anatomia)/fisiopatologia , Engenharia Tecidual/instrumentaçãoRESUMO
OBJECTIVE@#To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial bone defects.@*METHODS@#Thirty New Zealand rabbits were divided into β-TCP /PLLA group (group A), pure PLLA group (group B) and contrast group (group C) randomly. The rabbits were sacrificed respectively after 4, 8, 12, 24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.@*RESULTS@#X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A. The defect region was filled with neonate osseous tissue completely during 12-24 weeks. X-ray score revealed that repair of bone defect results significantly better than group B and group C.@*CONCLUSIONS@#The β-TCP /PLLA composite is capable of repairing radial bone bone defects. β-TCP/PLLA scaffold is significant because of rapid degradation ability, good histocompatibility and osteogenic action.
