Atypical presentation of fibroepithelial polyp: a report of two cases / Apresentação atípica de pólipo fibroepitelial: um relato de dois casos

ABSTRACT Fibroepithelial polyps are benign non-epithelial tumors arising from mesodermal tissue and are commonly found on the skin. They can develop on the eyelid and surrounding area and rarely appear at other sites. While most cutaneous cases are diagnosed incidentally, the lesions may be symptomatic based on their location. The etiology of fibroepithelial polyps is not fully understood but may involve trauma, chronic irritation, allergic factors, and developmental or congenital causes. Although fibroepithelial polyps are benign lesions, they can be malignant in extremely rare cases. Herein we discuss 2 cases of fibroepithelial polyp with an atypical presentation and their treatment.

RESUMO Pólipos fibroepiteliais são tumores benignos não-epiteliais que surgem do tecido mesodérmico e são comumente encontrados na pele. Eles podem se desenvolver na pálpebra e na área adjacente, e raramente aparecem em outros locais. Embora a maioria dos casos cutâneos seja diagnosticada incidentalmente, as lesões podem ser sintomáticas com base em sua localização. A etiologia dos pólipos fibroepiteliais não é completamente compreendida, mas pode envolver trauma, irritação crônica, fatores alérgicos e causas de desenvolvimento ou congênitas. Apesar dos pólipos fibroepiteliais serem lesões benignas, podem ser malignos em casos extremamente raros. Aqui discutimos 2 casos de pólipo fibroepitelial com uma apresentação atípica e seu tratamento.

Atypical presentation of fibroepithelial polyp: a report of two cases.

Fibroepithelial polyps are benign non-epithelial tumors arising from mesodermal tissue and are commonly found on the skin. They can develop on the eyelid and surrounding area and rarely appear at other sites. While most cutaneous cases are diagnosed incidentally, the lesions may be symptomatic based on their location. The etiology of fibroepithelial polyps is not fully understood but may involve trauma, chronic irritation, allergic factors, and developmental or congenital causes. Although fibroepithelial polyps are benign lesions, they can be malignant in extremely rare cases. Herein we discuss 2 cases of fibroepithelial polyp with an atypical presentation and their treatment.

Lipomatous tumors of the breast: A contemporary review.

Breast tumors with lipomatous or liposarcomatous components are infrequently encountered, but can be a source of diagnostic difficulty if the context of the fatty differentiation is not recognized. Among the true adipocytic tumors, lipoma is the most common lipomatous tumor arising in the breast. Several mammary spindle cell tumors may show adipocytic differentiation, including fibroepithelial tumors and myofibroblastoma. Liposarcomatous components most often arise in malignant phyllodes tumors, as opposed to primary liposarcomas of the breast which are believed to be uncommon. This article will review the spectrum fat-containing tumors of the breast with an emphasis on differential diagnosis and insights from recent molecular studies.

Hipoplasia dérmica focal unilateral / Unilateral focal dermal hypoplasia

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Is endoscopic management suitable for long ureteral fibroepithelial polyps?

BACKGROUND AND PURPOSE: Fibroepithelial polyps of the ureter are rare benign tumors that have traditionally been managed by open exploration and resection. Endoscopic resection have been regarded as the gold standard for small lesions, while the management modality for long lesions is still controversial. We review our experience with ureteroscopic management of long (>6 cm) ureteral fibroepithelial polyps by holmium: yttrium-aluminum-garnet (YAG) laser resection. PATIENTS AND METHODS: Five patients with a long ureteral fibroepithelial polyp underwent ureteroscopic resection using a holmium:YAG laser. RESULTS: Endoscopic management was successful in all five patients, and no major complications resulted from the approach. The average length of stay was 3 days (range 2-5 d). The mean length of the lesions were 11 cm (range 6-16 cm). The ureteral stent was removed at 6 weeks. No recurrences were seen during a mean followup of 24.2 months (range 3-51 mos). One ureteral stricture developed at 3 months, and the patient underwent endoscopic treatment by holmium:YAG laser. CONCLUSIONS: Endoscopic management of long ureteral fibroepithelial polyps is an acceptable modality with minimal morbidity and durable treatment results. The holmium:YAG laser offers the advantages of facilitating the use of a small-caliber fiber or flexible ureteroscope and allows safe destruction of the stalk and efficient removal of the entire polyp.

[Fibroepithelial lesions of the anal canal: therapeutic technique with rubber band ligation]. / Lesiones Fibroepiteliales del Canal Anal: alternativa terapéutica con ligadura de bandas elásticas.

When fibroepithelial lesions of the anal canal increase in size and bleed, they can produce tenesmus and a sensation of a foreign body in the anus. Generally, these lesions are surgically excised. We present an original non-surgical technique using rubber band ligation. In the Gastroenterology Department of the "Edgardo Rebagliati Martins" National Hospital (EsSALUD) between June 2000, and June, 2007, 16 patients with anal fibroepithelioma were included: 6 men and 10 women, with an average age of 44, aged between 21 to 75, and 44% aged 20 to 29. All of these patients (100%) had anal tumors, 50% had prolapses, 28% had anal pain and, 12% intermittent slight bleeding. The lesions had a polypoid appearance and sizes ranged from 1-5 cm. The technique consists in injecting 2% Xylocaine to the lesion, which is then retracted with surgical tweezers through the ring of the device holding the rubber band, which is then released leaving a safety margin of 5 to 10 mm over the skin. Biopsies of 11 lesions were taken and their analysis confirmed that there were 10 fibroepitheliomas and squamous epithelium. There was involution of the lesions due to ischemic necrosis in subsequent days. Patients only required oral analgesics for the first hours after procedure; only one patient presented an acute anal fissure. This non-surgical alternative performed on outpatient basis has proved to be effective and exempt from further complications.

Clinical, pathological and immunohistochemical study of feline mammary fibroepithelial hyperplasia following a single injection of depot medroxyprogesterone acetate.

Feline mammary fibroepithelial hyperplasia (FMFH) following a single injection of depot medroxyprogesterone acetate (MPA) was observed in eight intact young queens. The repository compound is marketed as a veterinary product by a local pharmaceutical company with an indication for contraception in cats. The drug was administered according to the recommended doses and injection frequencies. Serum hormone assays performed immediately before neutering and 3 weeks after neutering detected persistently high levels of progesterone suggesting that depot MPA was still exerting its influence. No corpora lutea were found in those cases ruling out ovaries as the main site of progesterone. Immunohistochemistry performed on the hyperplastic mammary glands detected progesterone receptors in the nuclei of ductal cells, and growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the cytoplasm of ductal epithelium. Overdosing should be considered here as the animals received at least 10 mg/kg of depot MPA in a single injection. Progestin-induced local synthesis of GH and IGF-I in mammary epithelial cells is suggested as one of the pathogenic mechanisms involved in the development of FMFH.

Enfermedad de Cowden: presentación de un caso y revisión de la bibliografía / Cowden disease: report of a case and review of the bibliography

La Enfermedad de Cowden (EC), también conocida como 'Síndrome de Neoplasias-Hamartomas Múltiples', es una rara e infradiagnosticada entidad hereditaria autosómica dominante caracterizada por la presencia de múltiples hamartomas de origen mesodérmico, endodérmico y ectodérmico , así como por una alta incidencia de presentación de tumores malignos. Actualmente se clasifica como un síndrome preneoplásico hereditario. Describimos los hallazgos en un paciente con EC con especial énfasis sobre los aspectos de imagen, revisando las principales manifestaciones de esta entidad (AU)

Contemporary diagnosis and treatment of fibroepithelial ureteral polyp.

Fibroepithelial polyps of the ureter are rare, benign tumors often not easily distinguished from malignant transitional-cell carcinomas by radiologic means. Historically, many patients have undergone unnecessary nephroureterectomy for these lesions. With recent advancement in endourologic instrumentation, a biopsy-proven diagnosis of suspect upper-tract lesions can be made prior to definitive therapy. We describe a typical case of fibroepithelial ureteral polyp wherein the diagnosis and surgical treatment was accomplished entirely by endoscopic means.