ABSTRACT
Purpose : The study was carried out to evaluate the incidence of adverse reactions to antimalarial drugs among residents of a Nigeria university community with a focus on arte- misinin-based combination therapy (ACT). Specifically; the profile of use; and the reporting culture of people with respect to experienced reactions were noted. Method : Ques- tionnaires were administered to respondents at the university health centre between November 2006 and January 2007. Information on demographic characteristics; nature of experienced adverse reactions and the most frequently used ACT; among other questions; were collected. Descriptive statistics and Fisher's Exact test were used to evaluate the distribution of respondent's opinion. Result: The study achieved a response rate of 86. The results revealed that 210 (70.0) of respondents said they had used artemisinin-based combination drugs while 134 (44.7) said they used artemisinin derivatives alone as monotherapy for malaria treatment. Artesunate plus amodiaquine 94 (31.3) as a co-packaged product was the most commonly used ACT. Incidence of the experienced adverse reactions to ACT was reported to be generally mild and well tolerated. Conclusion : Efforts to improve the use of ACT in the management of acute uncomplicated P. falciparum malaria is recommended. Furthermore; an effective mechanism to improve reporting of adverse effects of ACT is also recommended