Albumin- bilirubin score as a non-invasive serum biomarker for advanced liver fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C infection: A case-control study

Background: In many health systems, primary care is the main source of health care services. Liver cirrhosis is a silent disease that causes no signs or symptoms until decompensation occurs. Therefore, a simple and readily accessible tool for predicting advanced liver fibrosis and cirrhosis is needed to aid general practitioners in primary care settings. Aim: To explore the predictive performance of Albumin Bilirubin (ALBI) score as a non-invasive serum biomarker for advanced liver fibrosis and cirrhosis. Methods: This case-control study was conducted at Zagazig University Hospitals, Egypt, and comprised 400 participants divided into two equal groups. Group (I): 200 chronic HCV patients with advanced liver fibrosis and cirrhosis [F3-F4] and Group (II): 200 healthy controls. ALBI score was calculated for all study participants. Results: The AUROC for the ALBI score was 0.832 (95% CI: 0.787-0.872) (p-value) Conclusion: ALBI score is reliable for predicting advanced liver fibrosis and cirrhosis and could be valuable in primary care

Variations of Arterial Supply of the Liver: C.T. Angiographic Study Among Sudanese Adults

Hepatobiliary surgery through laparoscopic approach is becoming a routine. Knowledge of extrahepatic arterial tree is essential for surgical and imaging procedures. Anatomical complexity is expected since the liver is developed by mergingof lobules with its separate blood supply. This makes a wide range of variations in the pattern of vascular arrangement and so reinforces the need for an accurate understanding of full spectrum of variations. This study aimed to investigate the variations in origin and distribution of extrahepatic arterial supply. Fifty volunteers (32 males and 18 females) aged 20­70 years were randomly recruited from the department of CT scan in Al Amal Hospital, Khartoum North, Sudan. The patients were already candidates for CT angiography with contrast for conditions other than hepatobiliary diseases. The reported data is related to those who accepted to participate in the study. Patients with history of hepatobiliary disease were excluded. 3D views of the scans were treated and the extrahepatic arterial tree was traced in a computer-based software. Key findings suggest that Michel's classification was considered the standard template for description ­ 76% of them showed Michel's type I classification. Types III and V constituted about 2%. About 4% of the cases were represented by types VI and IX. Other types of variations constituted about 12%. To conclude, although type I classification which describes the textbook pattern of hepatic artery distribution was significantly detected among the Sudanese population, other variants were to be considered since they are related to major arteries like aorta and superior mesenteric.

Evaluation of the repeated exposure of hexaflumuron on liver and spleen tissues and its mutagenicity ability in male albino rat

Background: Hexaflumuron (HFM) is an insect growth regulator (IGR); it is highly effective against a wide range of pests. Aim of the work: Due to the lack of toxicological assessments of this insecticide especially the formulation type, the objective of the present study was aimed to investigate the toxicological effects of repeated exposure of HFM formulation on adult albino rats. Materials and methods: Three groups were administered daily by gavage for (28 days) at dose of 11, 4, and 2.5 mg/kg b.wt respectively. In addition to control group. Results: The results of acute toxicity indicated HFM exhibited moderate to some extent high toxicity toward the treated rats. Slight tremors and bleeding from nose were observed. The repeated exposure results revealed the high and middle doses exhibited methemoglobinemia. Also, the HFM treatment led to increase in AST and ALT levels. The urea and creatinine levels were not significantly increased except the level of creatinine in high dose. According to the histopathological findings the middle and low doses of HFM revealed greater injurious in liver and spleen tissues than induced by high dose. HFM induced a statistically significant increase in the micronucleus (MN) frequency in a dose-dependent manner compared with a negative control group. Conclusion: So, it is obvious the middle and low doses induced damage in the liver and spleen organs while the high dose induced damage in blood, bone marrow, and kidney organs

Aspects épidémiologiques et cliniques des pathologies naso-sinusiennes en consultation dans une structure de santé de proximité de Bamako

Introduction : La pathologie naso-sinusienne occupe une place importante en ORL. Sa prise en charge passe par une étude de données de la circonscription concernée. Ce travail avait pour but d'établir le profil épidémiologique, et clinique des pathologies naso-sinusiennes. Matériels et méthode : Il s'agissait d'une étude transversale descriptive menée en consultation sur une période de six mois allant de janvier 2018 à juin 2018 dans l'unité d'ORL-CCF du Centre de Santé de Référence de la Commune V de Bamako. Ont été inclus tout patient venu pour la première fois en consultation dans ladite unité pour pathologie naso-sinusienne. Résultats : Les pathologies naso-sinusiennes ont représenté 12,62% des consultations qui s'élevaient à 1656 patients. Nous avons recensé 60,3% de femmes et 39,7% d'hommes. La tranche d'âge 21-30 ans a constitué 25,8% des cas. L'âge moyen a été de 29 ans, avec des extrêmes de 11 jours et 80 ans. Les motifs de consultation ont été l'obstruction nasale (41,6%), l'épistaxis (19,2%), et les rhinorrhées 12,4%. Les rhinites ont représenté 59,8%, les sinusites 20,1%, les corps étrangers et les épistaxis chacun 7,6% des diagnostics. Un cas de tuberculose nasale a été observé. Conclusion : Les pathologies naso-sinusiennes sont dominées par la pathologie inflammatoire et infectieuse

Antimicrobial resistance activity and molecular characterization of methicillin-resistant staphylococci isolates in Tripoli Central Hospital, Libya

Background: Nosocomial infections caused by methicillin-resistant Staphylococci could lead to increased morbidity and mortality, but little is known about the prevalence of infections with these organisms in healthcare facilities and in the community in Tripoli. This study investigated the in vitro susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase negative staphylococci (MRCNS) to antimicrobial agents, and determined the molecular characteristics of MRSA.Methods: This is a retrospective observational study aiming at determining the prevalence and antibiotic resistance pattern of (MRSA) and (MRCNS) isolated from non-duplicated clinical specimens in Tripoli Central Hospital (TCH) between June 2013 and June 2014. Isolates were identified using standard laboratory procedures. Antimicrobial susceptibility tests were carried out by disk diffusion method and automated systems. DNA of the MRSA isolates was used for PCR to determine the molecular analysis.Results: 218 isolates of Staphylococci were obtained, 71.6% were coagulase positive staphylococci (CPS) and 28.4% were coagulase negative staphylococci (CNS). 39.7% of CPS were MRSA, while 75.8% of CNS were MRCNS. The rates of hospital-acquired MRSA (HA-MRSA) and community-acquired MRSA (CA-MRSA) among MRSA isolates were 61.3% and 38.7% respectively. A similar trend was detected among MRCNS isolates, where 74.5% were HA-MRCNS and 25.5% were CA-MRCNS. All the MRSA and MRCNS isolates were susceptible (100%) to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin, daptomycin and moxifloxacin. Generally, hospital-acquired strains showed higher resistance rates than community-acquired ones to the most commonly tested non-beta-lactam antibiotics. 35.5% of all staphylococcal isolates exhibited mecA+ gene and 12.9% expressed mecC+. Meanwhile, 38.7% of MRSA isolates harbored both mecA and mecC. However, 12.9% of MSSA isolates were negative for both mecA and mecC. The mecA gene was detectable in 59.1% and 40.9 % of HA-MRSA and CA-MRSA isolates respectively.Conclusion: Hospital-acquired MRSA and MRCNS isolates had higher resistance rates to non-beta lactam antimicrobial drugs than the respective community-acquired isolates. This was shown by early detection of mecC gene among MRSA isolates

Bacterial Etiology of Diarrhoeal Diseases in Children Under 5 Years Old in Ombadda Hospital - Sudan

Abstract:This study was conducted in Ombadda hospital in order to isolate and identify the bacterial aetiology of diarrhoea in children under 5years of age and determine their antibiograms. Stool specimens were collected from children seeking treatment at Ombadda and Omdurman paediatric hospitals from April to September 2008. The stool specimens were cultured on conventional media; and the isolates were identified by biochemical tests; and confirmed by serology. Enteropathogenic E.coli (EPEC) was the predominant isolate (42.11); followed by Salmonella paratyphi B (31.58);Salmonella typhi (10.53) V. cholerae (10.53) and Shigella flexneri(5.26). The enteric bacterial pathogens were susceptible to cefuroxime and ceftriaxone.V.cholerae was susceptible to amoxicillin.This study showed high proportion of bacterial diarrhoea among children less than five years old. The most common causative agent is EPEC which is not part of routine investigation of stool culture in all of the laboratories in Sudan

The Prevalence of Multi-Drug Resistance-1 Gene of Plasmodium Falciparum Malaria in Gezira State-Central Sudan

Abstract:Malaria parasite resistance to chloroquine poses a severe and increasing health problem in tropical countries. Implementing molecular markers for monitoring the drug resistance may be essential to overcome the problem. The aim of the present study is to investigate the prevalence of multi-drug resistance of p. falciparum parasite in malaria patients. Blood samples for DNA extraction were collected from the positive malaria patients. The prevalence of mutations in P. falciparum multi-drug resistant gene-1 (pfmdr-1) was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) methods. Approximately; 74.1 of study populations are adults and 25.9 are children. Regression analysis shows a decrease in malaria incidence with increasing age. The prevalence of malaria is higher in males (58.6) compared to females (41.4). There were no statistical differences between malaria incidence and the socioeconomic level within the study population. The frequency of homozygous N/86 and Y/86 alleles were 51.7 and 37.9; respectively; and the heterozygous N/Y86 allele was 10.3.In conclusion the frequency of Pfmdr-1 N/Y86 allele among P. falciparum multi-drug resistant isolates support the hypothesis that Pfmdr-1 N/Y86 allele could be used as predictive marker to monitor multi-drug susceptibility in epidemiological surveys

Assessment of Existing Practices in the Operating Theatre in the Khartoum North Teaching Hospital; Sudan

This study; assessing existing practices in the operating theatre regarding hand washing; disinfection and sterilisation; was conducted at Khartoum North Teaching Hospital. As far as we know; this is the first study of its kind since the inauguration of the hospital in 1950. A total of 55 health personnel working in the operating theatre participated in the study. These included nurses and environmental service personnel (housekeepers and sterilisation and disinfection personnel). Knowledge and practice were evaluated using multiple choice and direct interview questions. Operation theatre sterilisation and disinfection practices were monitored using checklists modified from World Health Organization recommendations. A marked lack of knowledge and defective attitudes and practices were observed among a large number of personnel. It was observed that 51 of the nurses were 46 years of age or older and that two-thirds had only a primary and intermediate school level education. The study recommends the upgrading of the operating theatres and additional training and education of staff. Theatres should be provided with facilities for proper disinfection and waste disposal. Qualified nurses should be employed. We also recommend the establishment of an infection control committee. The role of the committee would include the planning and execution of hygiene policies. In addition; planning and organising training courses in infection control should be seen as a priority

Place de la thrombolyse dans l'embolie pulmonaire grave

But : l'embolie pulmonaire grave est une pathologie grevée d'une lourde mortalité supérieure à 20%.La thrombolyse fait parti des moyens thérapeutiques qui permettent de réduire cette mortalité. L'objectif de ce travail était de déterminer l'intérêt, les limites et les complications de la thrombolyse dans l'embolie pulmonaire grave. Malades et Méthode : il s'agit d'une étude descriptive portant sur huit cas d'embolie pulmonaire grave admis au Service de Cardiologie de l'Hôpital Général de Grand Yoff de Mars 2003 à Mars 2006. Toutes les embolies pulmonaires graves, confirmées à l'angio-scanner thoracique et ayant bénéficiées d'une thrombolyse, étaient incluses. Résultats : huit cas d'embolie pulmonaire grave étaient sur 32 embolies pulmonaires reçues durant cette période, soit une prévalence hospitalière de 25%. L'âge moyen était de 49,9 ± 19,1 ans (extrêmes de 15 et 72 ans) avec une prédominance féminine (sex-ratio de 0,33). Sept patients avaient un score de probabilité clinique de Wells d'embolie pulmonaire moyenne et un malade avait une probabilité clinique forte. Les signes de gravité étaient le collapsus cardio-vasculaire (7 cas), la syncope et l'arrêt cardiaque respectivement dans 1 cas. L'électrocardiogramme inscrivait 4 cas d'ischémie sous épicardique, un bloc de branche droit et un signe de Mac Ginn White (aspect S1Q3T3) respectivement dans 3 cas. Deux patients présentaient une opacité basale droite à la radiographie thoracique de face. L'échocardiographie Doppler notait une dilatation du ventricule droit (5 cas), un septum paradoxal et des thrombi multiples dans le ventricule droit respectivement dans 1 cas.L'angio-scanner thoracique mettait en évidence une embolie massive constante avec dans trois cas une embolie bilatérale et dans un cas un anévrysme des artères pulmonaires. Nos patients avaient bénéficié d'une thrombolyse à la Stréptokinase en plus d'une expansion volumique, d'amines sympathomimétiques et d'une anticoagulation

Diagnostic d'orientation et traitement des cancers thyroidiens au Mali

Notre objectif a ete de rapporter les criteres de diagnostic d'orientation des cancers de la thyroide dans les conditions de la pratique en zone sahelienne. Ce travail s'etait base surl'analyse de dossiers de 29 personnes porteurs de cancer de la thyroide; vus dans le serice d'Oto-Rhino-Laryngologie (ORL) de l'hopital Gabriel Toure de Bamako au Mali; de janvier 2002 a decembre 2007. Trois symptomes ont constitue le motif de consultation : tumefaction cervicale dure (21 as) evoluant depuis plus de 10 ans; presence de signes de compression (dysphonie :5 cas; dyspnee :3; dysphasie : 1) et des adenopathies cervicales (6 cas). La confirmation histologique du diagnostic a ete faite par analyse du produit cytoponction ou d'une piece operatoire. Le traitement majeur a ete le geste chirurgical dont l'analyse de la piece operatoire a permis de connaitre le diagnostic positif. L'orientation diagnostique pre-therapeutique a montre ainsi sa place preponderante dans un contexte d'absence d'exonne extemporane

Malignant Phylliodes Tumours: Results of Breast Conserving Surgery and Immediate Reconstruction

Background: Malignant phylliodes tumour (MPT) is a rare breast tumor. Surgery is the mainstay in treatment but varies from local resection to modified radical mastectomy. In this study; we present our experience using wide local excision or subcutaneous mastectomy and immediate breast reconstruction in the management of MPT. Methods and Results: Twenty-three recurrent MPT and ten patients with histological evidence of MPT were included. All patients with recurrent MPT (n=23) had subcutaneous mastectomy; tow centimeter wide excision of the scar and immediate breast reconstruction with either Latissimus Dorsi (LD) myocutaneous flap (n= 10) or Latissimus Dorsi muscle flap (n=13). Seven of the newly diagnosed patients had wide local excision of the tumor; reconstruction with LD muscle flap; tow had wide local excision and reduction of contra lateral breast; and one had subcutaneous mastectomy and silicon implant. The margin resection varied between five and fifteen centimeter in wide local resection group and subcutaneous mastectomy group respectively and the size of tumors varied between five and fifteen centimeters in diameter. Discussion: During the follow up period; which ranged between twenty-four and eighty-four months one local recurrence; was recorded (3.03) and none of the patients had distant metastasis or regional lymph nodes involvement. This approach has secured wider excision of MPT; offered breast reconstruction; and has reduced the chances of recurrence in our patients

Morbidite par tumeurs de la sphere tete et cou a Bamako

Ce travail rapporte sur une annee (nov 2004-oct 2005) les resultats d'une etude descriptive realisee sur les tumeurs de la tete et du cou dans le service ORL de l'hopital Gabriel Toure de Bamako. Ont ete inclus tous les patients dont les dossiers comportaient les parametres suivants : epidemiologique (age; sexe; profession; residence et delai de consultation); facteurs d'exposition; localisation anatomoclinique et resultat histologique; et les donnees de l'imagerie. Ont ete exclues toutes les tumeurs de cette region dont les dossiers etaient incomplets ainsi que les tumeurs de l'oeil et de ses annexes et les tumeurs endocraniennes. Nous avons pu colliger 60 cas; et 25 dossiers n'ont pu etre exploites. Parmi les 60 cas retenus; 24 tumeurs etaient des tumeurs malignes (40) et 36 tumeurs benignes. Dans les tumeurs benignes; le goitre a ete le plus retrouve avec a l'etude histologique une predominance de l'adenome colloidal (15 cas sur 36 soit 41;67). D'autres tumeurs rares ont ete notees entre autre le rhinosclerome (5 cas soit 13;89); le papillome inverse des fosses nasales (2 cas soit 5;55). Ces tumeurs benignes n'ont pas pose de problemes de prise en charge. Quant aux tumeurs malignes; nous avons eu une predominance de cancers pharyngo-larynges (11 cas/24) avec le carcinome epidermoide comme type histologique le plus frequent. Dans ce lot on a eu deux carcinomes chez des enfants de moins de quinze ans. Nous n'avons pas pu relever de particularites; entre autre pas de facteurs d'exposition individualisable. D'autres tumeurs malignes tels que les cancers nasosinusiens et les carcinomes de la thyroide ont ete relevees. Ces tumeurs malignes ont generalement consulte a un stade avance de la maladie

Corps etranger du pharynx de decouverte fortuite

Les corps etrangers de l'oropharynx posent rarement de difficultes tant sur le plan diagnostic que therapeutique. Le diagnostic est le plus souvent evident chez l'adulte. Nous rapportons un cas de corps etranger de l'oropharynx observe chez un patient; psychologiquement stable; au decours d'un traumatisme. Le patient a ete admis dans un tableau de dysphagie 2 mois apres le traumatisme. Le corps etranger etait meconnu par le patient. Il a ete extrait par voie endo-buccale sous anesthesie generale 2 mois apres le traumatisme. La nature; la decouverte fortuite et la longue duree de sejour rapportees ici en constituent l'interet

Les cancers laryngo-pharynges dans un service de sante de dernier recours au Mali : aspects anatomo-cliniques et therapeutiques

Le but de ce travail etait de decrire les aspects anatomo-cliniques et therapeutiques des cancers laryngo-pharynges au Mali. Il s'agissait d'une etude prospective descriptive et transversale qui s'est deroulee dans le service d'ORL et de chirurgie cervico-faciale du centre hospitalo-universitaire Gabriel TOURE sur un an allant du 1er Avril 2006 au 31 Mars 2007. Elle a porte sur 18 malades hospitalises dans ce service pour cancer du larynx ou de l'hypopharynx confirme a l'histologie. Les parametres (l'age; certains facteurs favorisants; les signes cliniques; l'aspect endoscopique de la tumeur; le type histologique et le type de traitement) ont ete analyses. Les hommes ont ete les plus touches (66;7); l'age moyen etait de 58;17 ans. Le tabagisme chronique a ete le facteur de risque le plus evoque (55;5) avec une consommation moyenne de 39;5 P/A. un retard de consultation a ete note (60a un delai superieur a 1 an apres l'apparition des premiers symptomes). L'aspect bourgeonnant (66;7) et e type carcinome epidermoide de la tumeur (94;7) ont domine le tableau d'anatomie pathologique. Seuls 27;8de nos patients ont beneficie d'un traitement chirurgical; compte tenu du retard accru de diagnostic

Cellulite peri-orbitaire et poly sinusite paranasale : analyse de deux cas colliges au service ORL de l'hopital Gabriel Toure de Bamako; Mali. Cas clinique

Les auteurs rapportent deux cas de cellulites periorbitaires colligees sur une annee dans le service ORL. Ces deux cas ont la particularite d'etre survenue chez des enfants dans un contexte de pyorrhee alveolodentaire et de poly sinusites faciales associees. Le parcours therapeutique avant l'hopital a ete emaille de traitement traditionnel dans un cas et d'automedication dans l'autre. Dans les deux cas le medecin referent a ete un ophtalmologiste. Les deux patients ont ete admis en hospitalisation ORL au stade de phlegmon periorbitaire collecte ayant necessite un drainage chirurgical sous anesthesie generale. Les suites operatoires ont ete simples; cependant un des enfants admis au stade d'une acuite visuelle reduite a la simple perception lumineuse n'a pas recupere de sa perte de vision

Lymphome de Burkitt pediatrique a revelation ORL: quelle prise en charge en milieu sub sahelien ? Reflexion sur trois cas

Le lymphome de Burkitt dans sa forme Africaine peut se manifester sous des signes d'emprunt ORL a type de tumefaction orbito-maxillo-faciale. Le diagnostic peut etre fait par les ORL a travers un faisceau de signes cliniques et une cytoponction. La prise en charge se fait dans des unites d'oncologie medicale ou le bilan d'extension et le lancement de la chimiotherapie sont des imperatifs incontournables. Actuellement cette tumeur a potentiel tres agressif repond a une poly chimiotherapie bien conduite

Les goitres benins en ORL. Aspects epidemiologiques et anatomocliniques : etudes de 97 cas

But : Analyse epidemiologique; clinique et anatomopathologique des goitres benins. Methodologie : Etude retrospective de janvier 2002 a decembre 2006 sur dossier de patients ayant consulte en ORL pour goitre. Les parametres suivant ont ete etudies : - interrogatoire : age; sexe; profession; residence; anciennete du goitre; motif de consultation ; - examen clinique precisant resultats palpation; classification OMS de 1962 du goitre ; - resultats de l'echographie ; - resultats du dosage de la TSH ultrasensible. Ont ete exclus tous les dossiers comportant une histologie suspecte et/ou maligne et les inflammations de la thyroide. Ainsi a-t-on retenu 97 dossiers sur 122. Resultats : Notre recrutement a ete marque par une forte proportion d'adulte jeune (classe d'age de 31 a 50 ans : 78 patients) et par une predominance feminine (sex-ratio; 17/80).Ces patients etaient plus souvent des femmes au foyer et residaient le plus souvent a Bamako. Ils etaient porteurs a 52 de goitre evoluant depuis plus de vingt ans et a 44 de plus de dix ans d'evolution. Deux signes principaux ont amenes les patients a consulter : les signes d'hyperthyroidie et la tumefaction cervicale disgracieuse. Le goitre etait de type 3 de l'OMS dans 68 des cas. Un aspect multi nodulaire clinique a ete vu chez 81 patients. A l'imagerie; nous avons note 10 de goitre isoechogene. L'examen anatomopathologie a plus souvent trouve des goitres de type macro folliculaire sur les pieces d'exerese. Ils etaient dans 20 des cas des goitres en activite. Conclusion : Le praticien ORL en pays d'endemie goitreuse se doit de connaitre tous les contours de la pathologie thyroidienne. Il ne doit jamais oublier non plus que la prise en charge efficiente doit etre multidisciplinaire (Endocrinologue; Radiologue; Anatomopathologiste; Anesthesiste Reanimateur)

The Efficacy of Artemether/Lumefantrine for the Treatment of Uncomplicated Falciparum Malaria in Children in an Area of High Transmission in Southern Sudan

"Objectives: Sudanese health authority adopted a new antimalarial drug policy in response to the reported high level of chloroquine resistance. ""Artesunate+ sulfadoxine/pyrimethamine"" (ASP) and ""artemether/lumefantrine"" (A/L) are recommended as first and second lines for the treatment of uncomplicated falciparum malaria respectively. This study aims to evaluate the clinical and parasitological response to A/L and to report any side effects related to the drug in children living in high transmission areas. Methods: This evaluation of the clinical and parasitological response to directly observed treatment with 6 doses A/L following WHO protocol for monitoring antimalarial drugs efficacy. Giemsa-stained thick and thin blood smears were examined microscopically. Results: A total of 75 (40.8) patients met the inclusion criteria; of them 70 (97.2) patients showed adequate clinical and parasitological response (radical cure); 2 (2.8) patients were classified as early treatment failure and 3 (4) patients were lost to be followed-up by day 3. No progression to severe illness or danger signs occurred for any patient during the study. Conclusion: The main outcome of study was that A/L was found to be highly effective against Plasmodium falciparum uncomplicated malaria; well tolerated by children with no reported serious side effects. Dramatic decrease in parasites density and fever were observed in most of the cases by day 3 of treatment."

Apoc impact assessment study Onchocerciasis: baseline ophthalmological Survey in southwestern Sudan

A cross-sectional survey of eye disease supported by the African Programme for Onchocerciasis Conffol (APOC) was carried out in October 1998, in Raja, Sudan, a Savanna ecological zone to determine the prevalence and distribution of onchocercal eye disease. Detailed eye examination including measurement of visual field using the Wu-Jones computerized Motion Sensitivity Screening Test (MSST) were carried out. A total of 481 individuals were examined, of which 379 underwent detailed eye examination. A high prevalence of blindness (8.1%) from all causes was recorded. Onchocerciasis-induced eye disease was responsible for blindness in 56.40/o of all blind persons. Of the 38 persons who had visual impairment, 13 (2.7%) were severely affected. As many as 91 (24.0%) persons had microfilariae (mfs) in the anterior chamber (AC) and /or cornea with the highest prevalence of 29.3Yo and 28.8% respectively, recorded among the young and active individuals. This age group (15-24yeus) also had the highest prevalence (15.3%) of flufff corneal opacities. Sclerosing keratitis was present in 46 (12.1%) subjects while iridocyclitis was diagnosed in 9.0% with the highest prevalenc e of 25 .0o/o noted in the 45 - 54 age group. Prevalence of blinding cataract was 54.1% while that of glaucoma was12.2%. Presumed optic nerye disease, a known pathway to onchocercal blindness was observed in 19.6% with one third of this percentage already at the advanced stage. Another common pathway to blindness, chorioretinitis, affected 15.2% of the subjects of which 7.2% had reached advanced stages.Prevalence of abnormal visual fields was 6.6Yo. Posterior segment oncho disease was found to be the main ocular pathology in 15.6% subjects followed closely by 13.5% whose main cause was anterior segment oncho lesion. Both sexes were almost equally affected. Ocular findings in this area particularly among the young conform to high intensity levels of onchocerciasis infection and therefore require urgent effective intervention to forestall further devastating oncho-induced blindness and alleviate the socio-economic burden imposed on this population.