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Article in English | AIM | ID: biblio-1270593

ABSTRACT

Pseudomonas aeruginosa is one of the most common nosocomial pathogens in intensive care units (ICUs); with an increased prevalence of multidrug resistance in nosocomial infections. This study aimed to determine antibiotic synergy profiles of multidrugresistantP. aeruginosa originating from ICU patients in a teaching hospital in Pretoria; South Africa. Susceptibility studies and in vitrosynergy testing were performed; utilising agar dilution and Etest methodology; respectively. Susceptibility studies revealed 94of isolates exhibiting resistance to more than three anti-pseudomonal agents tested. Results from antibiotic synergy studies suggested that cefepime (p0.0001) or meropenem (p0.0001) in combination with amikacin are possible treatment options available in this specific setting


Subject(s)
Anti-Bacterial Agents , Cross Infection , Drug Resistance , Pseudomonas aeruginosa
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