ABSTRACT
Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema; analgesic; antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves. Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1; tail flick method is used to study analgesic property; hyperthermia was induced by subcutaneous injection of 15of a brewers' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or HCl/ethanol mixture. Results: The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It inhibited; in a dose- dependent manner; the oedema induced by 0.1 ml of formaldehyde 1. Scores of 73.70and 83.63were obtned when the doses of extract administered were 100 and 500 mg/kg; respectively. The tail flick analgesic index showed an increase of 36.56when the dose was 500 mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000 mg/kg of the extract inhibited 63.77of the gastric lesion induced by acid-water-ethanol mixture while daily administration of the same dose accele- rated the cicatrisation of gastric ulcer induced by 95ethanol. Conclusion: The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger (Lillia- ceae) has anti-inflammatory; anti-ulcer and wound healing properties
Subject(s)
Aloe , Anti-Inflammatory Agents , Anti-Ulcer Agents , Plant Extracts , Stomach UlcerABSTRACT
46 malades hospitalises presentant un ulcere gastrique ou duodenal prouve par endoscopie ont fait l'objet d'une etude retrospective. La frequence hospitaliere de cette pathologie etait de 1;5 pour cent. Les ulceres etaient le plus souvent uniques; de siege duodenal plutot que gastrique et de forme ronde et ovalaire. Les patients etaient en majorite des hommes; ages de 20 a 40 ans dans la moitie des cas; et generalement souvent issus de couches socio-professionnelles a bas niveau de vie. La minifestation clinique la plus frequente etait la douleur epigastrique (67;34 pour cent); typiquement ulcereuse seulement dans 54;35 pour cent des cas. Les complications hemorragiques etaient frequentes (50 pour cent des cas); revelatrices dans 36;95 pour cent des cas. Aucun cas de deces n'a ete note