Cardiac Death Risk in Diabetic Haemodialysis Patients Increased Due to Thyroid Problems

A prospective study found that diabetic haemodialysis patients' subclinical hyperthyroidism and euthyroid sick syndrome might increase the risk of sudden cardiac-related deaths. Dr Christiane Drechsler; of University Hospital Wurzburg in Wurzburg; Germany; and colleagues conducted a study that included 1 000 patients undergoing haemodialysis for diabetes. Of those patients; 78.1 had euthyroidism; 13.7 had subclinical hyperthyroidism; 1.6 had subclinical hypothyroidism and 5.4 had euthyroid sick syndrome

Reduced Thyrotropin in Euthyroid Goitrous Patients Suggesting Subclinical Hyperthyroidism

B a c k g r o u n d : Subclinical hypertyhroidism; a biochemical finding of low serum thyrotropin (TSH) with the serum levels of thyroxine (T4 ) and triiodothyronine (T3) within the reference range; could easily be ignored by clinicians; as it; usually; does not manifest with any thyroid specific symptoms. It is of two types : endogenous and exogenous. However; patients with the findings of low TSH; normal T4 and T3 develop some abnormalities in the cardiovascular system; such as atrial fibrillation; increasein left ventricular mass and diastolic dysfunction. It is believed that treatment intervention may reduce or halt the progression of the cardiac abnormalities. The main objective of the study was to determine how frequent subclinical hyperthyroidism was occurs and to serve as a reminder to the existence of the disorder. Methods : It was a hospital-based study carried out at the Jos University Teaching Hospital (JUTH). Consecutive clinically euthyroid goitre patients attending the outpatient department of JUTH; were studied for various parameters including TSH; T4 and T3. The serum concentrations of T4 and T3 were determined by enzyme-linked immunosorbent assay (ELISA) technique. The serum TSH concentration was estimated using a 2nd generation ELISA technique. Results : 98 patients participated in the study. Nine patients had non-specific symptoms not referable to the thyroid and found to have high levels of thyroid hormone concentration with depressed TSH and were excluded from further analysis; while 7 had subclinical hyperthyroidism giving a prevalence rate of 7.9among these clinical euthyroid goitre patients. The subjects with this condition were mainly above 60 years of age and mainly had long-standing goitre. Conclusion: Endogenous subclinical hyperthyroidism was present in 7.9of these clinically euthyroid goitre patients mainly 60 years and above; with long - standing goitre. This high prevalence rate calls for high index of suspicion as this condition is associated with morbidities that can raise mortality

In vitro Heparin Precipitation in the Plasma of Euthyroid women with Recurrent Miscarriage and Unexplained Infertility

OBJECTIVE: Women with elevated Lp(a); who are susceptible to atherosclerosis; get to reduce; their cardiovascular disease by in-vivo administration of low dose heparin. And history of recurrent miscarriage associated with auto antibodies have had a high rate of life births in subsequent pregnancies when they were treated with low dose aspirin together with low dose heparin. An in-vitro assay thus provide basis for the intricate interaction.DESIGN: Two hundred and ten (210) healthy volunteered Euthyroid women were used for this study. They were aged between 21-35 years; 90 Women served as test groups and 120 women served as control. Antimicrosomal autoantibody (Anti-TPO) ELISA assay was determined. The plasma treatment at the different PH with heparin and aspirin in physiological buffers were carried out.RESULT: At PH5.0 (i.e. the Uterus physiological PH) using 100i.u/ml heparin in 0.2M acetate buffer yielded 70 precipitate compared to treatment with 250i.u/ml heparin in 0.2M buffer that yielded 40 precipitate while 100-i.u/ml heparin with 80mg aspirin treatment yielded 65 precipitate in the test group samples that were positive to Anti-TPO. Whereas in the 0.2ml acetate buffer alone (without heparin and aspirin) no precipitate was formed; compared to the precipitate formed with plasma of the control women yielding 15 using 100i.u/ml heparin ;5with 250i.u/ml heparin and 12 100-i.u/ml heparin with 80mg aspirin treatment respectively.At PH 4.6 (i.e blood physiological PH ) for the various treatment showed there were increases in percentage precipitate; more in the subjects than in the control groups. In the unexplained and spontaneous abortion; groups with the treatment of 100iu/ml Heparin in 0.2M acetate buffer gave highest precipitate compared to other treatment in in-vitro study. CONCLUSION: This study has further supported that Heparin in addition to its anticoagulant action; may act to reduce fetal loss by binding to antimicrosomal; (anti-phospholipids) antibodies; thereby protecting the trophoblast phospholipids attack; and thereby promote successful implantation in early pregnancy