ABSTRACT
The intraperitoneal administration of amitriptyline [10 mg/kg body weight for 14 days] resulted in a significant decrease in blood glucose, significant increase in the blood insulin level, significant decrease in the levels of free fatty acids [FFA], triglycerides and total cholesterol. It also produced a significant decrease in both sodium and potassium levels and an increase in brain GABA level. However, T3, T4, TSH and brain L-glutamic acid showed no change. The probable significance of the findings is discussed
Subject(s)
Amitriptyline/pharmacology , Animals, LaboratoryABSTRACT
The effect of amitriptyline and maprotiline [5 mg/kg body weight] on gastric secretory activity was studied in rats. Th2 volume of the gastric secretion, hydrochloric acid concentration and peptic activity were determined. The effect of the drugs on phenylbutazone induced ulcers was also studied. The results showed a significant reduction in hydrochloric acid concentration and peptic activity. Amitriptyline caused a significant reduction in the volume of the gastric secretion and imparted a protective effect on the gastric mucosa
Subject(s)
Gastric Juice , RatsABSTRACT
Gliclazide [Diamicron] is an oral hypoglycemic drug which belongs to the sulphonylurea compounds. Gliclazide was administered orally to male rabbits in a dose of 200 micro g/Kg/day. The drug was suspended in gum acacia mucilage [1%] in a concentration of 200 micro g/ml. Each of the control rabbits received 1.0 ml gum acacia mucilage [1%] orally. Treatment was performed daily for four weeks, then blood was collected for the determination of the levels of thyroid stimulating hormone [TSH], triiodothyronine [T[3]] and thyroxine [T[4]]. Treatment with gliclazide resulted in a significant decrease in the levels of TSH and T[3] and a non significant decrease in T[4]. Possible mechanisms underlying this antithyroid effect of gliclazide are then discussed