ABSTRACT
Protective effect of Withaferin-'A' against CCl4 induced hepatotoxicity has been assessed and the compound at 10 mg/kg dose was found to possess significant protective effect. A comparison of this protective effect with that of hydrocortisone showed it to be as effective as hydrocortisone dose per dose.
Subject(s)
Alkaline Phosphatase/blood , Animals , Blood Proteins/analysis , Carbon Tetrachloride/toxicity , Drug Interactions , Ergosterol/administration & dosage , Female , Hydrocortisone/administration & dosage , Liver/drug effects , Liver Diseases/chemically induced , Male , RatsABSTRACT
The acute effect of single dose of ethanol (1.5 g kg) and aspirin (10 mg/kg) alone and in combination, on platelet aggregation time and platelet adhesiveness were studied in rabbits. There was a significant and comparable increase in aggregation time both by aspirin and ethanol. Similarly platelet adhesiveness was decreased by both the agents.
Subject(s)
Animals , Aspirin/pharmacology , Ethanol/pharmacology , Female , Male , Platelet Adhesiveness/drug effects , Platelet Aggregation/drug effects , RabbitsABSTRACT
A new withanolide, with a unique chemical structure similar to the aglycones of the cardiac glycosides, with mol. wt. 488 6, m. p. 260-261 degrees, isolated from the fruits of Withania coagulans, was screened for cardiovascular effects. At doses of 5 mg/kg body weight, the withanolide produced a moderate fall of blood pressure in dogs (34 +/- 2.1, mm Hg) which was blocked by atropine and not by mepyramine or propranolol. In rabbit Langendorff preparation and ECG studies, it produced myocardial depressant effects but in perfused frog heart it produced mild positive inotropic and chronotropic effects.