Effect of lynestrenol and mestranol on some electrolytes [sodium, potassium, calcium and magnesium] in serum, urine and aorta-experimental and clinical observation

The effect of the two synthetic steroid hormones, mestranol and lynestrenol, on sodium, potassium, calcium and magnesium on serum, urine and aorta were investigated. Mestranol alone lead to a significant rise in serum sodium and a decrease in serum potassisum but lynesdtrenol is naturitic. The sodium content of the aorta decreases with mestranol and increases with lynestrenol. Serum magnesium increases with lynestrenol. The changes with mestranol was insignificant. Ser um calcium level decreases with Lyndiol therapy; this may suggest that combined oral contraceptives do not lead to bone re-sorption. So the combined use of lynestrenol and mestranol may minimize the electrolyte disturbance which occurs with either of them

Variation of prostaglandins output in response to variation in electrolyte intake

This investigation is concerned with the effect of different salt levels [Normal, High and Low] diet on the level of PGE[2] in young females with an age ranging from 20-25 years, Kept on the corresponding diet for 15 days. PGE[2] level was detected in peripheral blood using RIA technique of Bernard and Harold [1973]. On the basis of the findings of Daniels et al., [1967] who proved that the depressorvaso lipid found in the crude renomedullary extract of PGE[2]derived from the kidney of man [Daniels, 1971], and also Drop 1971, who proved that renal medulla synthesizes large concentrations of PGE[2]. We may illustrate our findings in the following: In case of the groups treated with high salt diet, a significant rise in the level of PGE[2] was detected. Accordingly we may consider that PGE[2] has a lowering effect on the blood pressure with regards to its natriuretic effect, while in case of the low salt diet non significant decrease occured

Effect of lynestrenol and mestranol on serum trace metals [copper-zinc-iron] experimental and clinical observation

1- The effect of the two synthetic steroid hormones lynestrenol and mestranol on serum copper, zinc and iron was investigated in female rats and in women. 2. There was a rise of serum copper with mestranol and a decrease in its level with lynestrenol. 3. Serum copper rises with the combination of the two hormones in Lyndiol I. This rise was progressive with the duration of therapy. 4. Serum zinc decreases with Lyndiol both in the pre-and post-menstrual period under Lyndiol I medication. In rats, serum iron rises with mestranol. The relation between serum copper and zinc can be used as a test for the selection of cases or discondinuation of treatment with oral pill, especially in rural areas with endemic bilharziasis