Synthesis of some mannich bases of 2-, 4- amino and 2,4-Diamino-6-Methylpyrimidines as potential biodynamic agents

The synthesis of certain Mannich bases of 2-, 4-amino, and 2, 4-diamino-6-methylpyrimidines and their antimicrobial and antileukemic activities are described. Likewise, application of the Mannich conditions to 2-amino-4-[p-hydroxyanilino]-, 4-amino-2-[p- hydroxyanilino]-, and 2-amino-4-[p-acetylanilino]-6-methylprimidines using piperazine as the secondary amine afforded the corresponding bis-Mannich bases

Synthesis and evaluation of some 2-, 4-, and 2, 4distributed-6-methyl pyrimidine derivatives for antimicrobial activity

The reaction of 2-amino-4-chloro-, 4-amino-2-chloro-, and 2,4- dichloro-6-methyl-pyrimidines with primary aromatic amines under acidic conditions is presented. 2-, and 4-w substituted thio- ureide-6- methylpyrimidines were synthesized via the reaction of 2-amino-,and 4- amino-6-methylpyrimidine derivatives with aryl- isothiocyanates: Six compounds were evaluated for their antimicrobial activity and most of them showed a moderate activity against B subtilis, E. coli, and A. Niger