Primarily study on the number of lymphocyte T and B in patients with atopic dermatitis

21 patients with the atopic dermatitis, ages of 49.1+/-15.7 (inpatient and outpatient) in Friendship hospital and the Central Institute of Dermatology and Venerology during 9/1997- 4/2000 participated to a study. The results have shown that the absolute amount of lymphocyte CD3, CD4, the ratio of CD4/CD8 and CD19 in patients with the atopic dermatitis were insignificant different from these in control group. The amount of CD were significantly reduced but not significantly increase the ratio of CD4/CD8. There was no relation between CD3, CD4, CD8, ratio of CD4/CD8 and CD 19 with the severity of disease.

Clinical features of atopic dermatitis in adult

This prospective study was designed to evaluate the major and minor features of Hanifin and Rajka in 100 adult patients with atopic dermatitis. The results showed that 65% of the patients had 4 major features and 80% had 6 minor features. The specific features included itchy (100%), chronic progress (100%), history of atopic conditions (79%), lichenification in flexural areas (78%), non-specific hand dermatitis (75%), onset before 5 years of age (74%), xerosis (63%). Non-specific features included the progress has been influenced by environmental and emotional factors (100%), white dermographism (79%). Uncommon features included Denie-Morgan folds (5%) and anterior neck folds (5%). Based on these results, a minimum clinical diagnostic criteria was proposed, by which to be diagnosed with atopic dermatitis, a patient must have itching plus 4 or more followed features: history of atopic conditions, lichenification in flexural areas or eczema on face in children under 10 years of age, chronic progress, non-specific hand dermatitis, onset before 5 years of age and xerosis.

Changes of IgE and eosinophil in atopic dermatitis

The total serum IgE level and blood eosinophil count were evaluated in 44 adult patients with atopic dermatitis and were compared with 13 healthy controls for IgE level, and with 31 healthy controls for eosinophil count. It is found that both mean of IgE levels (X+/-SD=1129.86+/-984.54 IU/mL) and absolute number of eosinophils (X+/-SD = 0.857+/-0.736 G/L) were significantly elevated in comparison with control groups (p<0.001). There was closed correlation between IgE level, eosinophil count and severity of disease (r=0.60, 0.58 respectively with p<0.01). There was weak correlation between IgE level and eosinophil count with r = 0.22.

Study on eficacy and safety of fucicort in the treatment of allergic dermatitis

A study on 35 patients with the allergic dermatitis, ages of 41.23 treated in Friendship hospital during 5-7/2000 has shown that fucicort had a good effect in the first week and best in the second week. There was no adverse effects found. Patients tolerated well the drug.

Study on pilot assay in manufacture of film coated tablet of ketoprofen with prolonged action

To obtain a prolonged-action dosage form of Ketoprofen, a technique for delaying drug release from insoluble inert matrix of ethyl cellulose was evaluated. It was incorporated with excipients such as lactose, starch, hydroxy propyl methyl cellulose. influence of lubricants on release profiles was also investigated. The best result was obtained from the formula that consists of ethyl cellulose, lactose, starch, hydroxy propyl methyl cellulose, magnesium stearate, talc, aerosil (appropriate rate) and is coated with Eudragit L 100 (1mg/cm2)

Colonization of Staphylococcus aureus in the skin of patients with atopic dermatitis

A prospective study was conducted on 35 patients (22 men and 13 women) with atopic dermatitis at the H÷u NghÞ Hospital from March 15, 2000 to May 19, 2000. Age of patients ranged from 37 to 72. Control group included 30 individuals without history of this condition and had not any sign of atopic diseases at baseline. The results showed that Staphylococcus aureus colonized in the skin of most of atopic dermatitis patients (85.7%). The more severe the condition, the higher the rate. This bacterium colonized in 100% of patients who have discharge lesions and in 100% of patients who have severe condition. S. aureus has sensitivity of 100% with vancomycine, 96.6% with fucidic acid, 93.3% with gentamycin, 73.7% with cephalothin, 63.3% with oxacilline and 56.7% with erythromycin.