therapeutic role of vitamin E and C on non syndromic sensorineural hearing loss

Antioxidants help in preventing further degeneration or possibly even reverse degenerative processes after they have been activated. Free radical scavengers, such as vitamin E and vitamin C, protect inner ear from oxidative damage. To evaluate the efficacy of two classes of agents found effective in preventing sensorineural hearing loss [antioxidants and low fat diet] and determine if it can improve the degree of hearing loss by preventing oxidative damage. fifty four patients were divided into two groups, twenty four patients were given vitamin E and C for two months and thirty patients were given low fat diet [without animal fats] for two months. Auditory function was monitored along with plasma concentrations of Beta carotene, vitamins A, E and C and lipid peroxidation. Also, zinc, copper, calcium, phosphorus and magnesium together with immunoglobulin G, M and A levels were estimated before and after treatment. Significant increase in antioxidants and decrease in lipid peroxidation was observed in the group which was given vitamin E and C. The addition of antioxidants significantly enhanced the evoked responsiveness over that observed with the low fat diet group indicating a putative role of antioxidants in the pathogenesis of sensorineural hearing loss. The findings showed that supplemental dietary antioxidant may have a beneficial role in the prevention of deafness. It also proved a relationship between low fat diet and improvement of hearing loss

Oxidative stress in nonsyndromic sensorineural hearing loss

Ototoxicity seems to result from the inhibition of cochlear antioxidant defenses, causing an increase in the amount of reactive oxygen species. These findings suggest a causal relationship between the formation of reactive oxygen species, oxidative stress and functional/morphological ear damage. auditory function was monitored along with plasma concentrations of copper, zinc, calcium, phosphorus, magnesium and iron. Further more, lipid peroxidation, beta carotene, vitamin A, E and C activities and immunoglobulin G, M and A levels were estimated. A significant decrease in calcium, phosphorus, beta carotene, and vitamin E activities as well as low levels of immunoglobulin G and M were found. The observed increase in lipid peroxidation is indicative for oxidative stress which suggests a putative role of antioxidants in the pathogenesis of sensorineural hearing loss. Conclusion: The results support the hypothesis that dietary and immune factors influence individual susceptibility to hearing loss. Further studies are needed to verify whether antioxidants, correction of deficient nutrients and/or immune modulation would improve sensorineural hearing loss

Mitomycin-C and Co2 laser cordectomy

This study was conducted on 19 patients with bilateral abductor paralysis. They were divided into 2 groups. In group A [9 patients], posterior cortectomy with Co2 laser was done. In-group B [10 patients], mitomycin c [MMC] was applied locally at the site of cortectomy. The recurrence rate of stridor was about 55.5% in-group A and 10% in-group B, after following the patients for one year. The resu1ts encourages the use of MMC with posterior cortectomy to improve it's results

Pseudocyst of the auricle

Pseudocyst of the auricle is an acute lesion that was thought to occur exclusively in Chinese males. In the present work, it was found to occur also in Egyptians, where it affects both males and females. It is caused by exposure to cold air current in a congenitally predisposed ears. In a trial to avoid recurrences after it's incision and drainage, quilting sutures with 5/0 vicryl was used to cause adhesions between the pseudocyst walls in 13 patients. No recurrence was reported in them. It is considered as an easy, safe and successful management for this acute lesion

Revesion triangular flap repair for unilateral cleft lip

Twelve Children with a history of cleft lip, which was repaired previously by single triangular flab repair; were reoperated upon again due to unsatisfactory result of the primary repair. The cause of failure of the primary repair to achieve criteria for success was mainly due to failure of repair of the or peculiars oris muscle which must be recut and properly directed and resutured again in the revesion operation, together with scar revision and Z plasty repair for the skin

Antilob - ear deformity

The auricular collapse against the side of the head less than 1.8 cm can be congenital or acquired. The name "antilop-ear deformity" is suggested for these cases to differentiate them from the iatrogenic, postoperative, telephone ear, reverse telephone ear and excessive setback deformities. An operation is suggested to correct the antilop - ear deformity which actually the reverse of that operation for correcting the top - ear deformity