Clinical application of minimal invasive liposuction system in thigh areas of liposuction / 中华医学美学美容杂志

Objective:To investigate the clinical application and surgical effect of minimal invasive liposuction system (MILS) method in the thighs liposuction.Methods:From July 2019 to March 2021, 868 patients were selected for thigh liposuction. Local anesthesia and intravenous anesthesia were used in all operations. The preoperative design and intraoperative procedures were carried out according to the requirements of MILS ? method. There was an average of 2 154.4 ml fat aspirated, and the average operation time was 156.8 min. Results:After 2-18 months of follow-up, 83.3% of the patients were discharged on the day of operation. The thigh line curve of the patients was fluent and the perimeter of upper thigh was significantly reduced. The satisfactory rate was 92.3%, and the incidence of complications was 2.8%. No severe complication occurred.Conclusions:MILS method is a safe and effective procedure to partition thighs liposuction area scientifically and finely. The MILS method makes the lumbar abdominal liposuction operation standardized, reduces unnecessary operation, shortens the liposuction learning curve, reduces the occurrence of complications, and achieves the best aesthetic effect.

Correlation of age and OCT features with efficacy of anti-VEGF agents for macular edema secondary to central retinal vein occlusion / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To explore the correlation between age, OCT characteristics and the efficacy of anti-vascular endothelial growth factor(VEGF)drugs in the treatment of macular edema secondary to central retinal vein occlusion(CRVO).<p>METHODS: Retrospective case-control study. From July 2017 to July 2019,47 eyes of 47 patients with CRVO were included and divided into group A(elderly group, age>50y, <i>n</i>=27)and group B(young and middle-aged group, age≤50y, <i>n</i>=20). All patients were received anti-VEGF therapy(3+PRN)and followed up for at least 12mo. The best corrected visual acuity(BCVA), the number of hyper-reflective dots(HRD), the average retinal thickness(ART)and central retinal thickness(CRT)were observed before and after treatment. The number of injections, the recovery rate of outer membrane(ELM)and ellipsoidal zone(EZ)were compared between the two groups, and the related indexes affecting visual prognosis were analyzed. <p>RESULTS: After anti-VEGF treatment, BCVA was improved, the number of HRD decreased, CRT and ART thinned in both groups. During the follow up of 12mo after treatment, the frequency of injection of anti-VEGF drugs in the elderly group was higher than that in the young and middle-aged group(8.4±2.1 times <i>vs</i> 7.3±1.7 times, <i>P</i>=0.047), but there was no difference in the recovery rates of ELM and EZ between the two groups. BCVA in the elderly group was correlated with the age, HRD, ELM and EZ(all <i>P</i><0.05). BCVA was correlated with age, ART, HRD, ELM and EZ in young and middle-aged patients(all <i>P</i><0.05). <p>CONCLUSION: Intravitreal injection of anti-VEGF drugs can effectively treat macular edema secondary to CRVO and the prognosis of young and middle-aged patients is better than that of elderly patients. Age and OCT indexes such as HRD, ELM and EZ are related to visual prognosis.

Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats / 神经科学通报·英文版

In the current study, we sought to investigate whether T-type Ca channels (TCCs) in the brain are involved in generating post-anesthetic hyperexcitatory behaviors (PAHBs). We found that younger rat pups (postnatal days 9-11) had a higher incidence of PAHBs and higher PAHB scores than older pups (postnatal days 16-18) during emergence from sevoflurane anesthesia. The power spectrum of the theta oscillations (4 Hz-8 Hz) in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred, while there were no significant changes in older pups. Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors. Moreover, the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro. TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane (1%). These data suggest that (1) TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes; (2) the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats; and (3) the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs.

Accuracy of different anatomic landmark methods in determining size of nasopharyngeal airway / 中华麻醉学杂志

Objective To evaluate the accuracy of different anatomic landmark methods in determining the size of nasopharyngeal airway.Methods Fifty-two patients of both sexes,aged 16-60 yr,of American Society of Anesthesiologists physical status Ⅰ to Ⅲ,with body mass index of 18-30 kg/m2,scheduled for elective awake craniotomy for supratentorial tumors under sedation-awake-sedation anesthesia,were included.For each patient,the distance from the apex of nose to the right tragus (NT),distance from apex of nose to the right mandibular angle (NM),and thyro-mental distance (TM) were measured and marked on a transnasal tube correspondingly.The patients were placed in supine position without pillow,topical anesthesia (nasal mucosal surface) was performed with 2％ lidocaine,and patients were sedated with midazo1am,propofol and dexmedetomidine.When Observer's Assessment of Alertness/Sedation Scale score was 2 or 3 points,the tube was transnasally inserted to each marked depth.When the three marked depths mentioned above were reached,the positions of the tube's tip were checked using a fiberoptic bronchoscope and recorded as:above epiglottis (the tip of the tube was placed between the epiglottis and the free edge of soft palate) or below epiglottis (the tip of the tube placed at or beyond the epiglottis).Results When the depth reached the NT mark,the tube's tip was above epiglottis in 14 cases (27％),and the tube's tip was below epiglottis in 38 cases (73％).When the depth reached the NM mark,the tube's tip was above epiglottis in 31 cases (60％),and the tube's tip was below epiglottis in 21 cases (40％).When the depth reached the TM mark,the tube's tip was above epiglottis in 52 cases (100％).Compared with the NM and NT methods,the TM method had a higher probability with the tube's tip above epiglottis when used to determine the depth of insertion (P＜0.01).Conclusion TM anatomic landmark method provides higher accuracy in determining the size of nasopharyngeal airway.

Intervention effects of mindfulness-based stress reduction on housebound elders with depression / 中华行为医学与脑科学杂志

Objective To explore the effect of mindfulness decompression therapy on the house-bound elders with depression. Methods By the stratified random sampling method,screening 1 371 more than 60 year old people in the community,86 cases housebound elders with depression were randomly divided into intervention group and control group. Intervention group received mindfulness decompression therapy in-tervention,and control group with blank control. The housebound state assessment scale and the Geriatric Depression Scale (GDS) were evaluated before intervention,4 weeks after intervention and 8 weeks after in-tervention. Results During the intervention period,3 cases were dropped out,83 cases were all included (41 cases in the intervention group and 42 cases in the control group). There was no significant difference between the two groups in the general situation before the intervention (P>0. 05),and the balance between the two groups was comparable. After intervention,the total score of housebound (8. 4±2. 0) and the total score of depression (12. 2±4. 3) in the intervention group were lower than those in the control group,and the differences were statistically significant(P<0. 05). Conclusion Mindfulness-based stress reduction can ef-fectively improve the depression and housebound condition of the elderly.

Correlation among oxidative stress and inflammatory factors ,apoptotic factors in rats with heart failure / 心血管康复医学杂志

Objective :To explore correlation among oxidative stress and inflammatory factors and apoptosis in rats with heart failure (HF).Methods :A total of 20 SD rats weighing 180～200g were randomly divided into sham operation group (n＝12) and HF model group (n＝8).After eight-week feeding ,cardiac function and hemodynamic indexes ,levels of su-peroxide dismutase (SOD) ,malondialdehyde (MDA) ,interleukin (IL)-10 and IL-18 ,inhibitory apoptosis protein Bcl-2 and pro-apoptosis protein Bax were measured and compared between two groups .Results :Compared with sham operation group ,there were significant reductions in levels of SOD [ (140.37 ± 7.84) KU/L vs.(80.89 ± 6.65) KU/L] ,IL-10 [ (63.04 ± 10.84) pg/ml vs.(25.24 ± 4.08) pg/ml] and Bcl-2/Bax [ (1.58 ± 0.20) vs.(0.45 ± 0.65)] ,and significant rise in levels of MDA [ (4.48 ± 1.26) μmol/mg vs.(15.99 ± 2.44) μmol/mg] and IL-18 [ (249.92 ± 24.65) pg/ml vs. (442.29 ± 32.98) pg/ml] in HF model group ,P＝0.001 all.Pearson linear regression analysis indicated that in HF rats , Bcl-2/Bax was significant positively correlated with SOD and IL-10 levels (r＝0.652 ,0.783 ,P＝0.001 both) ,and signif-icant inversely correlated with MDA and IL-18 levels (r＝ －0.644 ,－0.917 ,P＝0.001 both).Conclusion :During occur-rence and development of heart failure ,oxidative stress level rises and imbalance of inflammatory factor proportion occurs , which accelerate protein apoptosis ,then aggravate heart failure .

Evaluation of clinical laboratory parameters and blood culture in diagnosis and prognosis of sepsis / 国际检验医学杂志

Objective To investigate the effect of common laboratory blood parameters and blood culture on the diagnosis and prognosis of sepsis .Methods The clinical data of 40 patients with sepsis who were treated in our hospital from March 2015 to Oc-tober 2016 were retrospectively analyzed .Another 40 cases with non sepsis were selected as control group .Laboratory indexes ,and differences of blood culture in patients of two groups were observed .According to the blood culture ,patients with sepsis were divid-ed into positive group and negative group ,the differences of laboratory indexes of positive group and negative group were observed . Results The levels of white blood cell (WBC) ,C reactive protein (CRP) ,Alanine aminotransferase (ALT) ,Aspartate aminotrans-ferase (AST) ,blood urea nitrogen (BUN) and serum creatinine (Scr) in patients with sepsis were higher than those in patients without sepsis ;the positive rate of blood culture in sepsis group was significantly higher than that in control group (χ2 =45 .490 , P<0 .001);the positive rates of WBC ,CRP ,ALT ,AST ,BUN and Scr in the positive group were higher than those in the negative group;the levels of IL-6 ,hs-CRP and TNF-in the positive group were higher than those in the culture negative group (P<0 .05);the levels of WBC ,CRP ,ALT ,AST ,BUN and Scr in the death group were higher than those in the non death group .The levels of IL-6 ,hs-CRP and TNF-in patients with sepsis were higher than those in the non death group (P<0 .05) .Conclusion The positive rate of blood culture ,white blood cell ,CRP ,ALT ,AST ,BUN and Scr levels were higher in sepsis patients ,and were closely related to the prognosis of patients .

Effect of arginine dentifrice on remineralization of initial enamel carious lesions / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To evaluate remineralization efficacy of an arginine containing dentifrice on initial enamel carious lesions in vitro.</p><p><b>METHODS</b>Human enamel blocks with early lesions were prepared and randomly divided into three treatment groups: negative control group (distilled and deionized water), positive control group (fluoride containing dentifrice and 0.14% sodium monofluorophosphate), and test dentifrice group (8.0% arginine and 0.14% sodium monofluorophosphate). The lesions were subjected to a pH-cycling regime for 10 days. Surface enamel microhardness of the enamel blocks from each group was measured before and after pH cycling, and the surface microhardness recovery was calculated. Then, specimens were analyzed for enamel fluoride uptake (EFU) through acid etching method, after which they were treated in demineralization solution for a 2 h period of acid challenge. The other specimens were sectioned and examined through polarized light microscopy.</p><p><b>RESULTS</b>In the test dentifrice group, microhardness recovery and EFU were significantly higher than those in the negative control and positive groups. The test dentifrice group was significantly resistant to the acid challenge compared with the other groups. Conspicuous remineralization of enamel subsurface lesions was observed under polarized light microscopy among samples treated with test dentifrice, whereas the control groups showed no significant changes on enamel subsurface lesions.</p><p><b>CONCLUSION</b>This study presents the potential superiority of Pro-Argin dentifrice over conventional fluoride dentifrice in promoting the remineralization of initial enamel lesions.</p>

Application of adjacent aesthetic unit combined liposuction in upper arm / 中华整形外科杂志

<p><b>OBJECTIVE</b>To improve a better method to achieve the upper arm's circumferential harmony by using adjacent aesthetic unit combined upper arm liposuction.</p><p><b>METHODS</b>Liposuction of upper arm, axilla and part of the scapula area was performed on 88 cases at one stage from January 2007 to March 2013.</p><p><b>RESULTS</b>All the cases achieve satisfactory results. The circumferential curve is smooth and elegant. No severe complication happened.</p><p><b>CONCLUSIONS</b>This method proved to be safe and effective and can be accomplished in one stage.</p>

Effects of 45S5 bioglass on surface properties of dental enamel subjected to 35% hydrogen peroxide / 国际口腔科学杂志·英文版

Tooth bleaching agents may weaken the tooth structure. Therefore, it is important to minimize any risks of tooth hard tissue damage caused by bleaching agents. The aim of this study was to evaluate the effects of applying 45S5 bioglass (BG) before, after, and during 35% hydrogen peroxide (HP) bleaching on whitening efficacy, physicochemical properties and microstructures of bovine enamel. Seventy-two bovine enamel blocks were prepared and randomly divided into six groups: distilled deionized water (DDW), BG, HP, BG before HP, BG after HP and BG during HP. Colorimetric and microhardness tests were performed before and after the treatment procedure. Representative specimens from each group were selected for morphology investigation after the final tests. A significant color change was observed in group HP, BG before HP, BG after HP and BG during HP. The microhardness loss was in the following order: group HP>BG before HP, BG after HP>BG during HP>DDW, BG. The most obvious morphological alteration of was observed on enamel surfaces in group HP, and a slight morphological alteration was also detected in group BG before HP and BG after HP. Our findings suggest that the combination use of BG and HP could not impede the tooth whitening efficacy. Using BG during HP brought better protective effect than pre/post-bleaching use of BG, as it could more effectively reduce the mineral loss as well as retain the surface integrity of enamel. BG may serve as a promising biomimetic adjunct for bleaching therapy to prevent/restore the enamel damage induced by bleaching agents.

Latest progress in unveiling the oral microbial metagenome / 华西口腔医学杂志

The human resident microorganisms constitute the second genome of human body. Oral microbiome is closely related to the oral and systemic health and diseases. Implementation of high-throughput gene chip and second-generation sequencing has gained in-depth characterization of the oral microbiome, changing our view on host-microbe interactions. In this review, we summarized the latest progress in oral microbial metagenomics and addressed its potential value in the prevention and treatment of oral diseases and other systemic disorders.

Evolution rules and clinical value of apparent diffusion coefficient in cerebral infarction / 中南大学学报(医学版)

OBJECTIVE@#To determine the rules that apparent diffusion coefficient (ADC) changes with time and space in cerebral infarction, and to provide the evidence in defining the stage, guiding treatment or judging the prognosis in infarction.@*METHODS@#Eighty-eight work-ups in 69 patients with cerebral infarction (8 hyperacute, 35 acute, 20 subacute, and 25 chronic infarctions) were imaged with both conventional MRI and diffusion weighted imaging. The average ADC, the average relative ADC (rADC), and the ADC or rADC from the center to the periphery of the lesion were calculated.@*RESULTS@#The average ADC and the average rADC of hyperacute and acute infarction lesion depressed obviously. The average ADC and the average rADC of subacute infarction lesion were significantly higher than those of hyperacute and acute infarction lesion (P < 0.05), and some approached the values of uninjured side which appeared "pseudonormal values" at 10 to 14 days. The average ADC and the average rADC in chronic infarction lesion were the highest (P < 0.05). The longer the prognosis, the higher the average ADC and the average rADC of infarction lesion. The ADC and the rADC in 7 hyperacute and 26 acute lesions had gradient signs that these lesions increased from the center to the periphery. The ADC and the rADC in 15 subacute lesions had adverse gradient signs that these lesions decreased from the center to the periphery.@*CONCLUSION@#The ADC and the rADC of infarction lesions have evolution rules with time and space corresponding to the pathophysiological foundation. The evolution rules with time and those in space can be helpful to decide the clinical stage and pathophysiological phase of infarction, and to provide the evidence in guiding the treatment or judging the prognosis in infarction.

MRI diagnosis of cerebral sparganosis / 中华放射学杂志

Objective To analyze and evaluate the characteristics of cerebral sparganosis on MRI. Methods MRI appearances of 15 cases of cerebral sparganosis proven by pathology or serological test were retrospectively studied.Results A total of 21 lesions were found,some of them were single and some were multiple but asymmetrical.8 lesions were found in parietal lobe,6 in frontal lobe,2 in temporal lobe,2 in oceipital lobe,1 in basal ganglia,1 in cerebellar hemisphere and 1 in pons.The lesions carried slightly hypointense on T_1-weighted images and moderate hyperintense on T_2-weighted images.Most lesions showed pefilesional brain parenchyma edema.Enhanced MRI was performed in 10 cases,and all of them demonstrated abnormal enhancement such as peripheral ring-type,tortuous beaded shape or serpiginons tubular shape enhancement.Follow-up MR images in 6 eases were analyzed,and the location and shape of the lesions changed in 2 of them.Conclusion There are some specific MRI findings on cerebral sparganosis.Enhanced MRI and follow-up examination are important for the diagnosis of cerebral sparganosis.